The Anti-AIF1L Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody to AIF1L. This antibody recognizes Human, and Mouse antigen. The Anti-AIF1L Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Allograft inflammatory factor-1 (AIF-1) is an inflammation-related protein mainly produced by immune cells, such as monocyte/macrophages and activated T lymphocytes. It is essential for the survival and proinflammatory activity of immune cells. AIF1L is involved in the stabilization of podocyte morphology by titrating actomyosin contractility and membrane dynamics. Actin-bundling protein allograft-inflammatory-inhibitor 1 like (AIF1L) as a selectively expressed podocyte protein in vivo. We describe the distinct subcellular localization of AIF1L to actin stress fibers, focal adhesion complexes and the nuclear compartment of podocytes in vitro. Genetic deletion of AIF1L in immortalized human podocytes resulted in an increased formation of filopodial extensions and decreased actomyosin contractility