The Anti-COLCA1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-COLCA1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
C11orf92 (Colorectal Cancer Associated 1 or COLCA1) has multiple alternative 5' non-coding exons, and one constant exon that codes for a 124-amino acid protein. COLCA1 is a primate-specific gene. COLCA1 does not show homology to other proteins in public databases. Its secondary structure is predicted to possess a signal peptide, a transmembrane domain and O-linked glycosylation. COLCA1 is a primate-specific gene whose recent evolution may be similar to many positively selected genes among mammals that are frequently involved in immunity and defense. COLCA1 is present in granular organelles in eosinophils, mast cells, neutrophils, macrophages and dendritic cells in the gastrointestinal microenvironment. COLCA1 is a membrane protein of crystalloid granules in eosinophils, which contain the core protein MBP and matrix proteins (EPO, EDN and ECP). COLCA1 is expressed in many cells having a role in inflammation and cancer