The Rabbit Anti-UBPY/USP8 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Rabbit Anti-UBPY/USP8 Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, and Western Blot.
Description
Ubiquitin-specific peptidase 8 (USP8) was originally identified as a growth regulated ubiquitin-specific protease and is like many other DUBs characterized by its multidomain architecture. Besides the catalytic domain, specific protein-protein interaction modules were characterized which contribute to USP8 substrate recruitment, regulation, and targeting to distinct protein complexes. USP8 is a regulator of endosomal sorting and vesicle morphology in cultured cells. In vivo USP8 has a role strongly associated with acrosome biogenesis and that the early endosome pathway is significantly involved in the process. "In vivo" USP8 is predominantly expressed in the central nervous system and testis, two organs with highly polarized cells. In neuronal cells, USP8 could be involved in endosomal trafficking, retrograde transport, and synaptic plasticity. In disorders leading to neurodegeneration, USP8 is upregulated and could influence the neuron-oligodendrocyte interactions