MyBioSource.com's Anti-ATP12A Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Anti-ATP12A Antibody, Rabbit Polyclonal was generated using ATP12A as the antigen and it reacts with Human.
Description
ATP12A is an apically expressed nongastric H+ /K+ -ATPase that secretes hydrogen ions (H+ ) in exchange for potassium ions (K+ ) and is thought to be the primary physiologic acidifier of the airway surface liquid (ASL). ATP12A is emerging as an important pathogenic factor in Cystic Fibrosis (CF) and other chronic respiratory diseases such as asthma. Indeed, in normal airways, the proton secretion operated by ATP12A is expected to be compensated by the parallel bicarbonate transport. In CF patients, loss of CFTR-dependent bicarbonate secretion leaves proton secretion unchecked. Interestingly, ATP12A was found to be expressed in human and pig, but not in murine, airways