MyBioSource.com's Anti-TEP1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
The complement-like protein thioester-containing protein 1 (TEP1) is a protein component of two ribonucleoprotein complexes: vaults and telomerase. The vault-associated small RNA, termed vault RNA (VR), is dependent upon TEP1 for its stable association with vaults, while the association of telomerase RNA with the telomerase complex is independent of TEP1. TEP1 contains the protein tyrosine phosphatase signature motif, and it possesses an intrinsic protein tyrosine phosphatase activity. TEP1 also shares extensive homology with tensin, a cytoskeletal protein localized to focal adhesions, and with auxilin, a protein involved in synaptic vesicle transport. TEP1 is a key factor in the immune response of the malaria vector Anopheles gambiae to pathogens. TEP1 is tightly regulated by conformational changes induced by cleavage in a protease-sensitive region. TEP1 may require access to the VR central loop for efficient binding