The Rabbit Anti-ARHGAP17 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Rabbit Anti-ARHGAP17 Antibody has been shown to work in the following applications: Immunocytochemistry, and Immunofluorescence.
Description
ARHGAP17 (also known as Rich1) was initially identified as a neuron-specific GAP involved in regulated exocytosis. ARHGAP17, a member of RhoGAPs, has been reported to be involved in the maintenance of tight junction (TJ) and epithelial barrier. ARHGAP17 is expressed broadly in human tissues. ARHGAP17 haS close relationship with Rho GTPase family members in multiple cellular processes in nervous cells and platelets. ARHGAP17 might serve as a tumor suppressor in colon cancer progression and metastasis through Wnt/beta-catenin signaling pathway. Rich1 might act as a crucial upstream negative regulator via its GAP domain in control of epithelial cell cycle, proliferation and focal adhesion through CDC42/RAC1-PAK1-ERK1/2 signaling pathway and F-actin dynamics