The Rabbit Anti-C13orf18 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Rabbit Anti-C13orf18 Antibody has been shown to work in the following applications: Immunocytochemistry, and Immunofluorescence.
Description
RUBCNL (RUN and cysteine rich domain containing beclin 1 interacting protein like) is a accessory protein of PtdIns3K complexes. RUBCNL primarily localizes to ER and autophagic structures and positively regulates autophagosome maturation. Mechanistically, RUBCNL antagonizes RUBCN to stimulate PIK3C3/Vps34 kinase activity and to recruit PtdIns3K and HOPS complexes to the autophagosome for their site-specific activation by anchoring to the autophagosomal SNARE STX17. RUBCNL is a vertebrate-specific autophagy regulator, and RUBCNL antagonizes RUBCN/Rubicon to activate the class III phosphatidylinositol 3-kinase (PtdIns3K) during late steps of autophagy. In addition, RUBCNL interacts with STX17 on autophagosomes to promote autolysosome formation