The Anti-MDH1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody to Malate dehydrogenase 1, and MDH1. This antibody recognizes Rat antigen. The Anti-MDH1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: EIA, Immunoassay, and ELISA.
Description
Malate dehydrogenases 1(MDH1/MDHA) is a soluble form of malate dehydrogenases. Malate dehydrogenases (MDH) is a group of multimeric enzymes consisting of identical subunits usually organized as either dimer or tetramers with subunit molecular weights of 30-35 kDa. MDH has been isolated from different sources including archaea, eubacteria, fungi, plants, and mammals. MDH catalyzes the NAD/NADH-dependent interconversion of the substrates malate and oxaloacetate. This reaction plays a key part in the malate/aspartate shuttle across the mitochondrial membrane, and in the tricarboxylic acid cycle within the mitochondrial matrix. The enzymes share a common catalytic mechanism and their kinetic properties are similar, which demonstrates a high degree of structural similarity. The three-dimensional structures and elements essential for catalysis are conserved between mitochondrial and cytoplasmic forms of MDH in eukaryotic cells even though these isoenzymes are only marginally related at the level of the primary structure