The Anti-HYPK Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-HYPK Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Huntingtin interacting protein HYPK (Huntingtin Yeast Partner K) is an intrinsically unstructured protein having chaperone-like activity and can suppress mutant huntingtin aggregates and toxicity in cell model of Huntington's Disease (HD). Heat shock response is an adaptive mechanism of cells characterized by upregulation of heat shock proteins by heat-induced activation of heat shock factor 1 (HSF1). The trans-activation ability of HSF1 is arrested upon restoration of proteostasis. HYPK is a heat-inducible protein and transcriptional target of HSF1. HYPK is a HTT-interacting chaperone that can reduce N-terminal mutant HTT-mediated aggregate formation and cytotoxicity in neuronal cell lines. HYPK is also known to be a part of ribosome-associated protein complex and present in polysomes