MyBioSource.com's Anti-MYO9B Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, and Immunofluorescence.
Description
Myosin IXb (Myo9b), a Rho GTPase-activating protein (RhoGAP) expressed in immune cells, is essential for coordinating the activity of Rho and is involved in epithelial cell cytoskeletal organization. The "motorized Rho inhibitor" Myo9b is a key molecular component required for spatially coordinated cell shape changes and motility. The role of MYO9B in celiac disease was suggested to relate to an epithelial barrier defect. The region to which MYO9B localize is also linked with inflammatory bowel disease (IBD). The MYO9B gene contributes to the maintenance of the intestinal barrier and it has been postulated as a risk factor for celiac disease (CD). MYO9B polymorphisms were associated with celiac disease and ulcerative colitis susceptibility, presumably through alteration of the intestinal permeability