MyBioSource.com's Anti-NAIF1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, and Immunofluorescence.
Description
Human nuclear apoptosis-inducing factor 1 (NAIF1) is located on chromosome 9q34.11 and encodes 327 amino acids with a homeodomain-like region and two nuclear localization signals at its N-terminal region. NAIF1 is conserved across diverse species, including human, mouse, crab-eating macaque, dog, chicken, and frog, and shares no obvious homology to any known genes or proteins. NAIF1 was predominantly localized in the nucleus. Overexpression of NAIF1 inhibited cell growth and induced apoptosis. Furthermore, NAIF1 transfection caused both decreases in mitochondrial membrane potential and caspase-3 activation. In summary, NAIF1 is a nuclear protein that induces apoptosis when overexpressed. NAIF1 acts as an oncogene and involves in tumorigenesis in several cancers. NAIF1 induces apoptosis in gastric cancer cells, and plays an inhibitory role in the initial steps of gastric cancer genesis, and may provide new strategies for developing anti-cancer drugs using small molecular polypeptides