The Anti-ARHGEF1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-ARHGEF1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
ARHGEF1 is a RhoA-specific guanine nucleotide exchange factor expressed in hematopoietic cells. ARHGEF1 regulates signaling by both G protein-coupled receptors and RhoA, and, consequently, is required for appropriate migration and adhesion of diverse leukocyte populations. ARHGEF1 promotes F-actin polymerization in neurons, probably through inhibiting the activity of the actin-depolymerizing factor cofilin. ARHGEF1 functions as a negative regulator of neurite outgrowth through regulating RhoA-cofilin pathway and actin dynamics