MyBioSource.com's Anti-RABGEF1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, and Immunofluorescence.
Description
RabGEF1 (also known as Rabex-5) is a guanine nucleotide exchange factor for Rab5 GTPase, which regulates early endosome fusion and vesicular trafficking in endocytic pathways. RabGEF1 is a negative regulator of TrkA-dependent neuronal differentiation and NMDA receptor-mediated signaling activation in NGF-differentiated PC12 cells. Keratinocyte-specific deletion of the gene encoding RAB guanine nucleotide exchange factor 1 (RABGEF1) severely impairs epidermal barrier function in mice and induces an allergic cutaneous and systemic phenotype. RabGEF1 is a negative regulator of IgE-dependent mast cell activation, and Rabgef1-/-and TSLP transgenic mice share many similar phenotypic characteristics, including elevated serum IgE levels and severe skin inflammation, with infiltrates of both lymphocytes and eosinophils. RabGEF1 contains a Vps9 domain, an A20-like zinc finger (ZnF) domain, and a coiled-coil domain, and inhibits Ras by promoting Ras mono-and di-ubiquitination