MyBioSource.com's Rabbit Anti-SMPDL3A Antibody is a Rabbit monoclonal antibody. The Rabbit Anti-SMPDL3A Antibody was generated using SMPDL3A as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: EIA, Immunoassay, and ELISA.
Description
SMPDL3A gene is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR alpha and LXRbeta function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases. The LXR genome landscape has been investigated in murine macrophages but not in human THP-1 cells, which represent one of the frequently used monocyte/macrophage cell systems to study immune responses