Anti-ZBP1 Antibody, Rabbit Polyclonal from MyBioSource.com

Z-DNA-binding protein 1 (ZBP1, also known as DAI or DLM1), initially reported as an interferon (IFN)-inducible tumor-associated protein, harbors nucleic acid-binding domains for left-handed helix (Z-form) and receptor-interacting protein homotypic interaction motif (RHIM) domains for protein homotypic interactions. ZBP1is recently identified as an innate sensor of viral infections and a target of viral evasion strategies, regulating cell death, inflammasome activation, and proinflammatory responses. ZBP1 also functions during development and can trigger perinatal lethality when its RHIM-dependent interactions are not restricted. ZBP1 regulates NLRP3 inflammasome activation as well as induction of apoptosis, necroptosis and pyroptosis in IAV-infected cells. Importantly, ZBP1 deficiency protected mice from mortality during IAV infection owing to reduced inflammatory responses and epithelial damage. ZBP1 is an innate immune sensor of influenza A virus (IAV) and highlights its importance in the pathogenesis of IAV infection