The Anti-RAIDD Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-RAIDD Antibody, Rabbit Polyclonal has been shown to work in the following applications: EIA, Immunoassay, and ELISA.
Description
Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD/RAIDD contains oneCARD domain and onedeath domain. CRADD/RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the interaction with caspase-2. FADD/MORT1 is a death domain (DD)-containing adaptor/signaling molecule that interacts with the intracellular DD of FAS/APO-I (CD95) and tumor necrosis factor receptor 1 and the prodomain of caspase-8 (Mch5/MACH/FLICE). CRADD/RAIDD has a dual-domain structure similar to that of FADD. CRADD/RAIDD has an NH2-terminal caspase homology domain that interacts with caspase-2 and a COOH-terminal DD that interacts with RIP. CRADD/RAIDD could play a role in regulating apoptosis in mammalian cells. CRADD/RAIDD is a apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD/RAIDD recruits caspase-2 to the TNFR-1 signalling complex