MyBioSource.com's Anti-SNX21 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Sorting nexins (SNX) orchestrate membrane trafficking and signaling events required for the proper distribution of proteins within the endosomal network. Their phox homology (PX) domain acts as a phosphoinositide (PI) recognition module that targets them to specific endocytic membrane domains. Comprising over 30 proteins in humans, SNXs are classified into sub-groups based on the presence of additional functional domains. One SNX sub-group that in humans comprises sorting nexin-20 (SNX20) and sorting nexin-21 (SNX21) are the SNX-PXB proteins. These proteins possess a C-terminal PX-associated B (PXB) domain which displays a tetratricopeptide repeat (TPR) fold that is typically involved in protein-protein interactions. While SNX20 and SNX21 share the same overall domain organisation and approximately 40% sequence conservation at the amino acid level, they are distinguished by an N-terminal extension in SNX21 that is predicted to include a short alpha-helical structure. SNX-L (or SNX21) gene includes 4 exons and 3 introns, and is located on chromosome 20q12-13.1 region, encompassing 8 kb. The SNX-L protein has a common PX domain shared by all SNX family members. The similarity of SNX-L PX domain to the PX consensus sequence is over 40%. PX domains have been shown to associate with specific phospholipids and membrane compartments