CD117/c-kit Antibody (ACK2)

Product Specs
ItemCD117/c-kit Antibody (ACK2) - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $419.00Supplier Page View Company Product Page
Catalog NumberNBP1-43359-0.1mg
ImmunogenMouse CD117
NCBI Gene AliasesMASTC, CD117, C-Kit, SCFR, PBT
Concentration0.5 mg/ml
TargetCD117/c-kit
CloneACK2
ApplicationsIF/IHC,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunohistochemistry Whole-Mount,Immunocytochemistry/ Immunofluorescence
ReactivityGuinea Pig,Human,Mouse,Rat
IsotypeIgG2b Kappa
FormatPBS (pH 7.2)
Quantity0.1 mg (also 0.025 mg, 0.05 mg)
Conjugate/TagUnconjugated
HostRat
ClonalityMonoclonal
NCBI Full Gene NameKIT proto-oncogene, receptor tyrosine kinase
PurityProtein A or G purified
Research AreaCancer, Cellular Markers, Cytokine Research, Hematopoietic Stem Cell Markers, Immunology, Innate Immunity, Mast Cell Markers, Mesenchymal Stem Cell Markers, Protein Kinase, Signal Transduction, Stem Cell Markers, Tyrosine Kinases
Antibody TypePrimary Antibodies
StorageStore at 4C. Do not freeze

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: The ACK2 monoclonal antibody reacts with mouse CD117, also known as c-Kit receptor, Steel factor receptor and stem cell factor receptor.

Sizes Available: 0.1 mg (also 0.025 mg, 0.05 mg)

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Questions and Answers

Has this c-Kit antibody been used in any specific experimental contexts?

Yes, the c-Kit antibody has been utilized in studies investigating the role of the immunoglobulin cell adhesion molecule CLMP in smooth muscle cells. For instance, it was shown to be essential for the expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in a mouse model, as detailed in the study by Langhorst et al. (2018).

What kind of biological samples can I use this antibody on?

The c-Kit antibody has been shown to work effectively in mouse models, particularly in tissues such as the intestine and ureter, where it plays a role in studying smooth muscle cell function and communication.

Can this antibody help in understanding diseases related to smooth muscle function?

Yes, the c-Kit antibody can be instrumental in research related to congenital conditions such as short-bowel syndrome, as it aids in elucidating the mechanisms of smooth muscle contraction and cell communication, which are critical in gastrointestinal motility and ureteral function.

Is there any evidence of this antibody's effectiveness in detecting specific proteins?

The c-Kit antibody has been shown to be effective in detecting Connexin43 and Connexin45 in smooth muscle cells, which are crucial for proper muscle contraction and coordination in the intestine and ureter, as highlighted in the research by Langhorst et al. (2018).

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Human umbilical cord blood-derived mesenchymal stem cells restored hematopoiesis by improving radiation induced bone marrow niche remodeling in ratsAnnals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische GesellschaftOctober 1, 2023El-Naseery NI, Elewa YHA, El-Behery EI, Dessouky AA.

(2) Transmembrane stem cell factor protein therapeutics enhance revascularization in ischemia without mast cell activationNature communicationsMay 6, 2022Takematsu E, Massidda M, Auster J, Chen PC, Im B, Srinath S, Canga S, Singh A, Majid M, Sherman M, et al.

(3) Sex differences in anatomic plasticity of gut neuronal-mast cell interactionsPhysiological reportsOctober 1, 2021Schwerdtfeger LA, Tobet SA.

(4) Cardiac c-Kit Biology Revealed by Inducible TransgenesisCirculation researchJune 22, 2018Gude NA, Firouzi F, Broughton KM, Ilves K, Nguyen KP, Payne CR, Sacchi V, Monsanto MM, Casillas AR, Khalafalla FG, et al.

(5) The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in miceDisease models & mechanismsFebruary 22, 2018Langhorst H, Jüttner R, Groneberg D, Mohtashamdolatshahi A, Pelz L, Purfürst B, Schmidt-Ott KM, Friebe A, Rathjen FG.#AB1745, 1:100), sheep anti-Connexin45 (Abcam, #ab16588, 1:1000), rat anti-c-kit (Novus Biologicals, #NBP1-43359, mACK2, 1:1000), rabbit anti-ASAM (Bioorbyt, #orb100510), rabbit anti-CLMP (Sigma, #HPA002385, 1:100),

(6) An organotypic slice model for ex vivo study of neural, immune, and microbial interactions of mouse intestineAmerican journal of physiology. Gastrointestinal and liver physiologyFebruary 15, 2016Schwerdtfeger LA, Ryan EP, Tobet SA.

(7) c-kit expression profile and regulatory factors during spermatogonial stem cell differentiationBMC developmental biologyOctober 27, 2013Zhang L, Tang J, Haines CJ, Feng H, Lai L, Teng X, Han Y.105805, BioLegend, San Diego, CA, USA), the monoclonal rat-anti-mouse Kit extracellular domain (1:200, NBP1-43359, NOVUS, Littleton, CO, USA), the monoclonal rat-anti-mouse Kit extracellular domain (1:100, KJ-14, Santa

(8) Development of an efficient targeted cell-SELEX procedure for DNA aptamer reagentsPloS oneJanuary 1, 2013Meyer S, Maufort JP, Nie J, Stewart R, McIntosh BE, Conti LR, Ahmad KM, Soh HT, Thomson JA.

(9) Ultrastructural features and possible functional role of kit-positive interstitial cells in the guinea pig corpus cavernosumInternational journal of impotence researchJuly 1, 2011Fu W, Song B, Li W, Shen W, Ji H, Wang Y, Zhen J, Zhou Z, Yan J.

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