ASC Polyclonal Antibody bs-34024R from Bioss Inc.

Description

Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases

Product Specs
ItemASC Polyclonal Antibody
CompanyBioss Inc.
Price $375.00Supplier Page View Company Product Page
Catalog Numberbs-34024R
Quantity100ul
Format0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol
ApplicationsWB, ELISA, IF
Conjugate/TagUnconjugated
Concentration1ug/ul
Antibody TypePrimary Antibody
IsotypeIgG
ReactivityHuman
HostRabbit
TargetASC
ClonalityPolyclonal
NCBI Full Gene NamePYD and CARD domain containing
NCBI Gene AliasesASC, TMS, TMS1, CARD5, TMS-1

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Questions and Answers

Can this antibody be used to study apoptosis in human and rat cells?

Yes, the ASC Polyclonal Antibody is reactive to both human and rat species, making it suitable for studying caspase-mediated apoptosis in these cell types. Its proapoptotic activity is primarily mediated through the activation of caspase-9, which is crucial for understanding apoptotic pathways.

What applications is this antibody suitable for in my experiments?

The ASC Polyclonal Antibody has been shown to work in Western Blotting, ELISA, and Immunofluorescence applications. This versatility allows researchers to utilize it in various experimental setups to investigate the role of PYCARD in apoptosis and inflammation.

Is there any information on the role of PYCARD in inflammasome formation that I can reference?

While specific articles citing this product are not available, it is known that PYCARD may be a component of the inflammasome, which includes proteins such as NALP2, CARD8, and CASP1. This complex is involved in the activation of proinflammatory caspases, which is relevant for studies on inflammation and immune responses.

What is the concentration of this antibody, and how should it be prepared for use?

The ASC Polyclonal Antibody has a concentration of 1 µg/µl. It is provided in a buffer containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin 300, and 50% glycerol, which helps maintain stability and activity during storage and use.