CNPase (D83E10) XP ® Rabbit mAb 5664S from Cell Signaling Technology

Product Specs
ItemCNPase (D83E10) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number5664S
Quantity100 µl
ApplicationsW, W-S, IP, IF-F
ReactivityH, M, R
TargetCNPase
HostRabbit
NCBI Gene AliasesCNP1, HLD20
ClonalityMonoclonal
NCBI Full Gene Name2',3'-cyclic nucleotide 3' phosphodiesterase
Research AreaNeuroscience
IsotypeIgG
CloneD83E10
Molecular Weight47

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) SirT2 Inhibition is Associated with Improvements in Depression-like Behavior and Memory Impairment in Olfactory Bulbectomized MiceMol NeurobiolApril 21, 2026Kohei Takahashi, Kazuhiro Kurokawa, Daiki Hiraga, Hiroshi Takeda, Minoru Tsujimyelin-associated glycoprotein (MAG; 1:1000; CST; #9043), cyclicnucleotide phosphodiesterase (CNPase; 1:1000; CST; #5664), contactin-associated protein (Caspr; 1:1000; Abcam, Cambridge, UK; ab246501), and β-actin (1:1000;

(2) Optic Nerve Head Spatial Transcriptomic Change in Nonhuman Primate Early Experimental GlaucomaInvest Ophthalmol Vis SciMarch 11, 2026Galen Williams, Jinho Lee, Gabriel Zangirolani, Juan Reynaud, Hongli Yang, Nicholas Marsh-Armstrong, Claude F. Burgoyne, Priya Chaudharyantibody). The sections were incubated with CNPase (myelin, 1:50; Cell Signaling Technology catalog 5664, rabbit) primary antibody overnight at 4°C in a humidified chamber. The sections were washed with PBS

(3) Constraint-induced movement therapy combined with mesenchymal stem cell transplantation promotes myelination and functional recovery by inhibiting PRKCD/MEK/ERK pathway in hemiplegic cerebral palsy ratsStem Cell Res TherAugust 21, 2025Xiaolin Guo, Liru Liu, Jie Luo, Tingting Peng Jr., You Wang, Shiya Huang, Xiaoli Zeng, Tingting Peng Sr., Aihua Chen, Mengru Zhong, et al.rabbit antibody to 2’,3’-cyclic nucleotide 3’-phosphodiesterase (CNPase) (Cell Signaling Technology, 5664S, 1:1000), rabbit antibody to myelin basic protein (MBP) (Cell Signaling Technology, 78896S, 1: 1000),

(4) CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria DysfunctionAnnals of Clinical and Translational NeurologyApril 25, 2025Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, et al.Zenon Alexa Fluor 647 mouse IgG Mouse2b labeling kit (Z25208, Invitrogen), the anti‐CNPase antibody (5664S, Cell Signaling Technology) was labeled with Zenon Alexa Fluor 488 rabbit labeling kit (Z25302, Invitrogen),

(5) Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged MiceGliaMarch 19, 2025Niki Ktena, Dimitrios Spyridakos, Alexandros Georgilis, Ilias Kalafatakis, Efstathia Thomoglou, Angeliki Kolaxi, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeosanti‐Atg5 (1:1000; rabbit, Novus, Cat# NB110‐53818), anti‐CNPase (1:1000; rabbit, Cell Signaling, Cat# 5664), and anti‐α‐Tubulin, clone DM1A (1:10,000; mouse, Sigma‐Aldrich, Cat# T9026). After three 5‐min washes

(6) Schwann Cell-Specific Ablation of Beclin 1 Impairs Myelination and Leads to Motor and Sensory Neuropathy in MiceAdvanced science (Weinheim, Baden-Wurttemberg, Germany)February 1, 2025Gambarotto L, Russo L, Bresolin S, Persano L, D'Amore R, Ronchi G, Zen F, Muratori L, Cani A, Negro S, et al.anti‐MAG (1:1000, Cell Signaling Technology, 9043S); rabbit anti‐CNP (1:1000, Cell Signaling Technology, 5664S); rat anti‐MBP (1:2000, Abcam, ab7349); rabbit anti‐MPZ (1:5000, Abcam, ab31851); guinea pig anti‐p62

(7) Endogenous histidine peptides are physiological antioxidants that prevent oligodendrocyte cell death and myelin loss in vivoGliaJanuary 1, 2025Sajrawi C, Odeh M, Tiwari AK, Agranovich B, Abramovich I, Zubedat S, Saar G, Shaulov L, Avital A, Reznik D, et al.polyclonal",Sigma-Aldrich,HPA038569 "Anti-GFAP, mouse monoclonal",Calbiochem,IF03L "Anti-CNPase, rabbit monoclonal",Cell Signaling Technology,#5664 "Anti-Iba1, rabbit monoclonal",Cell Signaling Technology,#17198 "Anti-MAG, rabbit monoclonal",Cell Signaling Technology

(8) Dysregulation of Myelination in Focal Cortical Dysplasia Type II of the Human Frontal LobeGliaDecember 24, 2024Catharina Donkels, Ute Häussler, Susanne Huber, Nina Tiesmeyer, Theo Demerath, Christian Scheiwe, Mukesch J. Shah, Marcel Heers, Horst Urbach, Andreas Schulze‐Bonhage, et al.0.5% Triton for 30 min at RT. Incubation with the CNPase antibody (1:100, Cell Signaling Technology #5664S) was performed under gentle shaking at 4°C for 5 days followed by treatment with the Cy‐3‐labeled secondary

(9) Alzheimer’s-linked axonal changes accompany elevated antidromic action potential failure rate in aged miceBrain ResearchOctober 15, 2024Matthew L. Russo, Gelique Ayala, Demetria Neal, Annalise E. Rogalsky, Suzan Ahmad, Timothy F. Musial, Morgan Pearlman, Linda A. Bean, Anise K. Farooqi, Aysha Ahmed, et al.rabbit anti-2’,3’-Cyclic-nucleotide 3’-phosphodiesterase (Cell Signaling Technologies; Catalog No. 5664S), 1:500 rabbit anti-myelin-associated glycoprotein (Cell Signaling Technologies; Catalog No. 9043S).

(10) Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cellsGliaOctober 1, 2024Hooman Bagheri, Hana Friedman, Amanda Hadwen, Celia Jarweh, Ellis Cooper, Lawrence Oprea, Claire Guerrier, Anmar Khadra, Armand Collin, Julien Cohen‐Adad, et al.(Cell Signaling #2118), anti‐2',3'‐Cyclic‐nucleotide 3'‐phosphodiesterase (CNPase) (Cell Signaling #5664), and anti‐MBP (Sigma‐Aldrich MAB386). One sample from each genotype and age was run on each gel resulting

(11) SIRT6 modulates lesion microenvironment in LPC induced demyelination by targeting astrocytic CHI3L1Journal of NeuroinflammationSeptember 28, 2024Jingyi Du, Yue Yin, Dong Wu, Can Diao, Tiantian Zhao, Fan Peng, Naigang Li, Dongshuang Wang, Jiaming Shi, Liyan Wang, et al.rabbit anti-PDGFRα, 3174 S, 1:1000, Abcam; rabbit anti-CC1, ab40778, 1:500, Abcam; rabbit anti-CNPase, 5664 S, 1:500, CST; mouse anti-SOX10, 66786-1-Ig, 1:1000, Proteintech; mouse anti-β-actin, 66009-1-Ig, 1:500,

(12) Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in miceiScienceFebruary 16, 2024Wei Y, Wang X, Ma Z, Xiang P, Liu G, Yin B, Hou L, Shu P, Liu W, Peng X.RRID: AB_476744 Anti-GFAP,Abcam,Cat#ab7260; RRID: AB_305808 Anti-CNP,Cell Signaling Technology,Cat#5664; RRID: AB_10705455 Anti-H3,Abcam,Cat#ab1791; RRID: AB_302613 Anti-mycn,Abcam,Cat#ab227822 Anti-myc,Abcam,Cat#ab32072;

(13) RIT1 regulation of CNS lipids RIT1 deficiency Alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocitiesHeliyonOctober 1, 2023Wu L, Wang F, Moncman CL, Pandey M, Clarke HA, Frazier HN, Young LEA, Gentry MS, Cai W, Thibault O, et al.(myelin basic protein, 1:1000 dilution, Cell Signaling, 78896), CNPase (1:1000 dilution, Cell Signaling, 5664), MAG (myelin associated glycoprotein, 1:1000 dilution, Cell Signaling, 9043), and GAPDH (1:5000 dilution,

(14) Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalonNeural developmentSeptember 8, 2023Talley MJ, Nardini D, Ehrman LA, Lu QR, Waclaw RR.(1:1000, Biogenesis, #4600 − 1509), Rat-BrdU (1:250, Abcam, #AB6326), Rbt-CNPase (1:500, Cell Signaling, #5664), MS-CC1 (1:100, Calbiochem #OP80-100UG), GP-Gsx1 (1:5000, [48]), Rbt-Gsx2 (1:4000, [49]), Ch-MBP (1:500,

(15) Deficiency in the omega-3 lysolipid transporter Mfsd2a leads to aberrant oligodendrocyte lineage development and hypomyelinationJournal of Clinical InvestigationJune 15, 2023Vetrivel Sengottuvel, Monalisa Hota, Jeongah Oh, Dwight L. Galam, Bernice H. Wong, Markus R. Wenk, Sujoy Ghosh, Federico Torta, David L. SilverBio-Rad, MCA409S), MAG (1:100, MilliporeSigma, MAB1567), CNPase (1:300, Cell Signaling Technology, 5664), GFP (1:500, Cell Signaling Technology, 2555), Olig2 (1:200, MilliporeSigma, MABN50), Ki67 (1:400,

(16) Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalusFluids and Barriers of the CNSJune 9, 2023Farrah N. Brown, Eri Iwasawa, Crystal Shula, Elizabeth M. Fugate, Diana M. Lindquist, Francesco T. Mangano, June GotoAbcam, ab5076), anti-rat CTIP2 (1:1000, Abcam, ab183032), anti-rabbit CNPase (1:100, Cell Signaling, 5664), anti-rat CD86 (1:200, BD Biosciences, 553,689), anti-rabbit ApoE (1:250, Abcam, ab183597), or anti-rabbit

(17) Inhibiting tau protein improves the recovery of spinal cord injury in rats by alleviating neuroinflammation and oxidative stressNeural Regeneration ResearchFebruary 8, 2023Guo-Liang Chen, Kai Sun, Xi-Zhe Liu, Kui-Leung Tong, Zi-Juan Chen, Lu Yu, Ning-Ning Chen, Shao-Yu Liuantibody,Primary,WB,CST,14097,Rabbit,AB_2798391 Anti-GAPDH antibody,Primary,WB,CST,5174,Rabbit,AB_10622025 Anti-CNPase antibody,Primary,WB,CST,5664,Rabbit,AB_10705455 Anti-MBP antibody,Primary,WB,CST,78896,Rabbit,AB_2799920 Alexa Fluor 594-conjugated

(18) Single-cell RNA-based phenotyping reveals a pivotal role of thyroid hormone receptor alpha for hypothalamic developmentDevelopment (Cambridge, England)February 1, 2023Sreenivasan VKA, Dore R, Resch J, Maier J, Dietrich C, Henck J, Balachandran S, Mittag J, Spielmann M.ab218011, ab109746, ab155279/ab227680 and ab53041, respectively; abcam), PLP1, CNP and MBP (mAb#28702, mAb#5664 and mAb#78896, respectively; Cell Signaling Technology), ARSG (AF4600, R&D Systems), TMEM117, SLCO3A1

(19) Hypomyelinating Leukodystrophy 10 (HLD10)-Associated Mutations of PYCR2 Form Large Size Mitochondria, Inhibiting Oligodendroglial Cell Morphological DifferentiationNeurology internationalDecember 16, 2022Torii T, Shirai R, Kiminami R, Nishino S, Sato T, Sawaguchi S, Fukushima N, Seki Y, Miyamoto Y, Yamauchi J.anti-2′,3′-cyclic nucleotide 3′-phospho-diesterase specific for myelin-forming glial cells (CNPase, Cat. No. 5664; IB, 1/500) from Cell Signaling Technology (Danvers, MA, USA); mouse monoclonal alpha 1 sodium potassium

(20) A new mouse model of Charcot-Marie-Tooth 2J neuropathy replicates human axonopathy and suggest alteration in axo-glia communicationPLoS geneticsNovember 1, 2022Shackleford G, Marziali LN, Sasaki Y, Claessens A, Ferri C, Weinstock NI, Rossor AM, Silvestri NJ, Wilson ER, Hurley E, et al.1:1,000 rabbit anti-PMP22 (Sigma Cat# SAB4502217), 1:1,000 rabbit anti-CNPase (Cell Signaling Cat# 5664), 1:1,000 rabbit anti-MAG (Invitrogen Cat# 34–6200), and 1:1,000 rabbit anti-HSP90a (Thermo Fisher Scientific

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CNPase (D83E10) XP ® Rabbit mAb

CNPase (D83E10) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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CNPase (D83E10) XP ® Rabbit mAb from Cell Signaling Technology

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