ISG15 (22D2) Rabbit mAb 2758S from Cell Signaling Technology

Product Specs
ItemISG15 (22D2) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2758S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetISG15
HostRabbit
NCBI Gene AliasesG1P2, IFI15, IMD38, IP17, UCRP, hUCRP
ClonalityMonoclonal
NCBI Full Gene NameISG15 ubiquitin like modifier
Research AreaUbiquitin and Ubiquitin-like proteins
IsotypeIgG
Clone22D2
Molecular Weight15

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Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) IGFBP-6 regulates breast cancer cell cycle progression by promoting exit out of G1Journal of Biological ChemistryFebruary 1, 2026Francisco J. Lariz, Shayla Hernandez, Diana C. Bautista-Tovar, Kevin D. HoustonMA), MX1 (#37849 Cell Signaling), MDA5 (#5321 Cell Signaling), IRF9 (#76684 Cell Signaling), ISG15 (#2758 Cell Signaling), Phospho-STAT1 (Y701) (#7649 Cell Signaling), STAT1 (#14994 Cell Signaling), Phospho-STAT2

(2) cGAS–STING Pathway Activation Enhances Antitumor Effect of Talaporfin Photodynamic Therapy Through ROS ProductionCancer ScienceOctober 1, 2025Makiko Sasaki, Mamoru Tanaka, Yasunari Sasaki, Yuki Kojima, Taketo Suzuki, Hirotada Nishie, Shigeki Fukusada, Naomi Sugimura, Keiji Ozeki, Takaya Shimura, et al.TBK1/NAK (E813G) (1:1000 dilution; 38,066; Cell Signaling Technology), ISG15 (22D2) (1:1000 dilution; 2758; Cell Signaling Technology), and STING (D2P2F) (1:1000 dilution; 13,647; Cell Signaling Technology).

(3) RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosusCell reports. MedicineMarch 18, 2025Ding X, Zhou Y, Qiu X, Xu X, Hu X, Qin J, Chen Y, Zhang M, Ke J, Liu Z, et al.the primary antibodies anti-RSAD2 (D5T2X) (rabbit, CST, 13996) and anti-ISG15 (22D2) (rabbit, CST, 2758T) (for human samples) and the primary antibodies anti-RSAD2 (rabbit, Proteintech, 28089-1-AP) and anti-ISG15 (F-9

(4) Development of nitroalkene-based inhibitors to target STING-dependent inflammationRedox BiologyAugust 1, 2024Fei Chang, Camilla Gunderstofte, Nicole Colussi, Mareena Pitts, Sonia R. Salvatore, Anne L. Thielke, Lucia Turell, Beatriz Alvarez, Raphaela Goldbach-Mansky, Luis Villacorta, et al.(Ab76493, Abcam, RRID:AB_1523836), anti-IFIT1(CST Cat# 14769, RRID:AB_2783869), anti-ISG15 (CST Cat# 2758, RRID:AB_2126200) and anti-Vinculin CST Cat# 18799, CST, RRID:AB_2714181) as loading control. In addition

(5) XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cellsCell ReportsFebruary 27, 2024Tao Zou, Meng Zhou, Akansha Gupta, Patrick Zhuang, Alyssa R. Fishbein, Hope Y. Wei, Diego Capcha-Rodriguez, Zhouwei Zhang, Andrew D. Cherniack, Matthew Meyerson,Bethyl Laboratories,Cat# A300-443A; RRID: AB_2219047 Rabbit monoclonal anti-ISG15,Cell Signaling Technology,Cat# 2758; RRID: AB_2126200 Rabbit monoclonal anti-G3BP1,Cell Signaling Technology,Cat# 17798; RRID: AB_2884888 Rabbit

(6) Vitamin D enhances type I IFN signaling in COVID-19 patientsScientific ReportsOctober 22, 2022Shirin Hafezi, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Hawra Ali Hussain Alsayed, Habiba Alsafar, Fatme Al Anouti, Qutayba Hamid, Rabih Halwani(cat#29,261), p-IRF3 (cat#29,047), IRF3 (cat#11,904), RIG-1 (cat#3743), MX-1 (cat#37,849), and ISG-15 (cat#2758). β-Actin (cat#8457) was used as loading controls. All the antibodies were purchased from Cell Signaling Technology

(7) Single-Cell Analysis Reveals the Range of Transcriptional States of Circulating Human NeutrophilsThe Journal of ImmunologyAugust 15, 2022Gustaf Wigerblad, Qilin Cao, Stephen Brooks, Faiza Naz, Manasi Gadkari, Kan Jiang, Sarthak Gupta, Liam O’Neil, Stefania Dell’Orso, Mariana J. Kaplan, et al.exposure. The chip was then probed using antibodies against the proteins ISG15 (Cell Signaling, cat 2758) and GAPDH (Cell Signaling, cat 5174), labeled with Alexa 488/Alexa 594, and scanned in an array scanner

(8) Acquired chemoresistance can lead to increased resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virusMolecular therapy oncolyticsMarch 17, 2022Goad DW, Bressy C, Holbrook MC, Grdzelishvili VZ.number 41494S, clone E9A2G, Cell Signaling), a 1:1,000 dilution of rabbit anti-ISG15 (catalog number 2758S, clone 22D2, Cell Signaling), a 1:1,000 dilution of rabbit anti-CDK14-PFTK1 (catalog number 21612-1-AP,

(9) Design and Evaluation of a Novel Peptide–Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like ProteaseJournal of Medicinal ChemistryJanuary 13, 2022Na Liu et al.Western blotting was performed using the following primary antibody dilutions: 1:1000 for anti-ISG15 (CST, 2758), 1:1000 for anti-GFP (CST, 2956), 1:1000 for anti-GAPDH (Biodragon, B1034) antibodies, and 1:1000 for

(10) Influenza A induces lactate formation to inhibit type I IFN in primary human airway epitheliumiScienceNovember 19, 2021Thyrsted J, Storgaard J, Blay-Cadanet J, Heinz A, Thielke AL, Crotta S, de Paoli F, Olagnier D, Wack A, Hiller K, et al.(GeneTex, #GTX632604, 1:100), anti-IFIT1 (Cell Signaling, #14769, 1:1000), anti-ISG15 (Cell Signaling, #2758, 1:1000), anti-Viperin (Cell Signaling, #13996, 1:1000), anti-STAT1 (Cell Signaling, #9172, 1:1000),

(11) Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like proteaseInternational Journal of Biological MacromoleculesOctober 1, 2021Yunxia Xu et al.containing 5% skim-milk for 1 h at room temperature and then overnight with anti-ISG15 (1:1000, CST, 2758), anti-GFP (1:1000, CST, 2956), anti-GAPDH (1:1000, Biodragon, B1034) antibodies at 4 °C. After three

(12) Mass Spectrometry Analysis of SARS-CoV-2 Nucleocapsid Protein Reveals Camouflaging Glycans and Unique Post-Translational ModificationsInfectious Microbes and DiseasesSeptember 1, 2021Zeyu Sun, Xiaoqin Zheng, Feiyang Ji, Menghao Zhou, Xiaoling Su, Keyi Ren, Lanjuan Liantibody (IBA Lifesciences, 2-1502-001, 1:1000), anti-Ubiquitin (CST 3933, 1:1000), anti-ISG15 (CST 2758, 1:1000), and anti-GAPDH (CST 5174, 1:1000) antibody and visualized by chemiluminescence detection kit. Acknowledgments The

(13) DNA templates with blocked long 3ʹ end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene lociG3 Genes|Genomes|GeneticsAugust 7, 2021Saptaparni Bandyopadhyay et al.of Viperin (Sigma; Cat. No. MABF106; 1:1000 dilution), ISG15 (Cell Signaling Technologies, RabMab # 2758S, 1:1000 dilution), beta-actin (Invitrogen, mouse monoclonal # 15G5A11/E2, 1:1000 dilution), and GFP

(14) Spleen Tyrosine Kinase Mediates Microglial Activation in Mice With Diabetic RetinopathyTranslational vision science & technologyApril 1, 2021Liu X, Xu B, Gao S.Western Blot was performed as previously described.11 All the antibodies used were Irf8 (#5628), Pu.1 (#2758), Syk (#13198), phosphor-Syk (#2710) (Cell Signaling Technology, Danvers, MA), cleaved vaspase 3 (#AF7022,

(15) SILAC-Based Quantitative Proteomic Analysis of Oxaliplatin-Resistant Pancreatic Cancer CellsCancersFebruary 10, 2021Kim YE, Kim EK, Song MJ, Kim TY, Jang HH, Kang D.Piscataway, NJ, USA), as recommended by the manufacturer. Primary antibodies were used for ISG15 (#2758), MARCKS (#5607), p-MARCKS (Ser159/163) (#11992), p-Akt (Ser473) (#9271), Akt (#9272), β-catenin (#9562),

(16) Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humansScience ImmunologyDecember 18, 2020Alon Schneider Hait et al.anti-phospho-STING (40818, Cell Signaling); anti-IFIT1 (14769, Cell Signaling 1:1000), anti-ISG15 (2758, Cell Signaling 1:1000), anti-HSV1-2 VP5 (ab6508, AbCam 1:1000), anti-ULK1 (8054S Cell Signaling technology,

(17) Design of an Interferon-Resistant Oncolytic HSV-1 Incorporating Redundant Safety Modalities for Improved TolerabilityMolecular Therapy - OncolyticsSeptember 25, 2020Edward M. Kennedy, Terry Farkaly, Peter Grzesik, Jennifer Lee, Agnieszka Denslow, Jacqueline Hewett, Jeffrey Bryant, Prajna Behara, Caitlin Goshert, Daniel Wambua, et al.antibodies were used for western blot analysis: Stat1 (#14994), Phospho-Stat1 Tyr701 (#9167), ISG15 (#2758) from Cell Signaling Technologies (Danvers, MA, USA), and beta actin HRP (#ab20272) from Abcam (Cambridge,

(18)

Inhibition of EGFR Signaling and Activation of Mitochondrial Apoptosis Contribute to Tanshinone IIA-Mediated Tumor Suppression in Non-Small Cell Lung Cancer Cells

OncoTargets and TherapyApril 2, 2020Feng Gao, Ming Li, Wenbin Liu, Wei LiBax (#14796), Cytochrome c (#4280), β-actin (#3700), Akt (#2920), ubiquitin (#3936), and α-Tubulin 2758 Powered by TCPDF (www.tcpdf.org) submit your manuscript | www.dovepress.com DovePress (#2144) were

(19) A Long Non-coding RNA IVRPIE Promotes Host Antiviral Immune Responses Through Regulating Interferon β1 and ISG ExpressionFrontiers in microbiologyJanuary 1, 2020Zhao L, Xia M, Wang K, Lai C, Fan H, Gu H, Yang P, Wang X.Cell Signaling), IFIT3 (sc-393512, Santa Cruz Biotechnology), Mx1 (37849S, Cell Signaling), ISG15 (2758T, Cell Signaling), IFI44L (HK7931, Hushi Pharmaceutical Technology), Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb

(20) Temporal Proteomic Analysis of BK Polyomavirus Infection Reveals Virus-Induced G₂ Arrest and Highly Effective Evasion of Innate Immune SensingJournal of virologyAugust 15, 2019Caller LG, Davies CTR, Antrobus R, Lehner PJ, Weekes MP, Crump CM.against Geminin (GeneTex), ab16895 against MDM2 (Abcam), 37849 against MX1 (Cell Signaling Technologies), 2758 against ISG15 (Cell Signaling Technologies), PA3-848 against IFIT1 (ThermoFisher), 12604-1-AP against

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ISG15 (22D2) Rabbit mAb

ISG15 (22D2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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ISG15 (22D2) Rabbit mAb from Cell Signaling Technology

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