Presenilin 1 (D39D1) Rabbit mAb from Cell Signaling Technology

Yes, the Presenilin 1 (D39D1) Rabbit mAb has been utilized in various studies related to Alzheimer's disease. For instance, it was employed in Western blot analysis to investigate the processing of amyloid precursor protein and the production of amyloid β-peptides, which are critical in Alzheimer's pathology (see arafi2024 and macias2014).

The Presenilin 1 antibody is reactive with multiple species, including human, mouse, rat, and non-human primates. This broad reactivity makes it suitable for comparative studies across different model organisms in neuroscience research.

Yes, the Presenilin 1 (D39D1) Rabbit mAb has been cited in studies examining γ-secretase activity, particularly in the context of its role in amyloid precursor protein processing and the implications for Alzheimer's disease (see hu2016 and takeo2024).

While specific details on immunoprecipitation applications are not provided, the antibody is listed for use in Western blotting, which often accompanies immunoprecipitation techniques to validate protein interactions and modifications, particularly in studies of γ-secretase complexes (see hu2016 and saito2024).