Stathmin-2/STMN2 Antibody

Product Specs
ItemStathmin-2/STMN2 Antibody - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $489.00Supplier Page View Company Product Page
Catalog NumberNBP1-49461
ImmunogenC-terminal peptide of mouse STMN2. [Swiss-Prot P55821]
Quantity0.1 mg
Conjugate/TagUnconjugated
HostRabbit
ApplicationsIF/IHC,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vitro assay,In vivo assay,Immunohistochemistry Whole-Mount,Knockdown Validated,Immunocytochemistry/ Immunofluorescence
FormatPBS
TargetStathmin-2/STMN2
ReactivityAvian - Chicken,Bovine,Human,Mouse,Rat
ClonalityPolyclonal
PurityImmunogen affinity purified
Research AreaNeuroscience
IsotypeIgG
Antibody TypePrimary Antibodies
StorageStore at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles
Concentration1.0 mg/ml
NCBI Full Gene Namestathmin 2
NCBI Gene AliasesSCG10, SCGN10

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Sizes Available: 0.1 mg

Questions and Answers

What species does this antibody react with, and has it been used in relevant studies?

The Stathmin-2/STMN2 antibody reacts with several species, including human, mouse, rat, bovine, and chicken. It has been utilized in various studies, such as in the research by Avraham et al. (2020), where it was employed for immunohistochemistry to investigate the role of satellite glial cells in nerve regeneration.

Can this antibody be used for immunofluorescence, and what are some examples of its application?

Yes, the Stathmin-2/STMN2 antibody has been shown to work in immunofluorescence applications. For instance, in the study by Cao et al. (2018), it was used to label sensory neurons in mouse adipose tissues, contributing to the understanding of sympathetic plasticity in response to cold-induced beiging.

How does the Stathmin-2/STMN2 antibody perform in terms of specificity for labeling regenerating axons?

The antibody has been demonstrated to selectively label regenerating axons in the sciatic nerve after injury, as shown in the work by Shin et al. (2014). This study highlighted its utility in distinguishing between regenerating and degenerating axons, making it a valuable tool for analyzing nerve regeneration.

What is the recommended dilution for using this antibody in immunohistochemistry?

The recommended dilution for the Stathmin-2/STMN2 antibody in immunohistochemistry is typically around 1:1000, as indicated in various studies, including those by Carlin et al. (2019) and Wang et al. (2023), where it was used effectively at this concentration for labeling purposes.

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
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Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Directional guidance to orient Schwann cell alignment in nerve regeneration requires Plexin-B1Sci AdvApril 24, 2026Jiaxi Li, Haofei Ni, Dalia Halawani, Molly Estill, Aarthi Ramakrishnan, Chrystian Junqueira Alves, Li Shen, Xijing He, Roland H. Friedel, Hongyan Zouab51824; 1:500), anti-S100B (host: chicken, Aves Labs, S100B; 1:500), anti-SCG10 (host: rabbit, Novus, NBP1-49461; 1:1000), anti-Tuj1 (host: mouse, BioLegend, 801202; 1:1000), anti-c-Jun (host: rabbit, Cell Signaling Technology

(2) SARM1 is required for macrophage immunophenotype switching that is essential for nerve repairbioRxivApril 9, 2026Julianna Bennett, Halimah Adesunkanmi, Noah Leever, Grace Bergeron, Josh Small, Cathryn Holladay, Grace Saxman, Rachel E. Williamson, Manshi Swain, Gavin Pearson, et al.#E307V 1:500), rabbit α-CD206 (Cell Signaling Technology #E6T5J 1:500), α-SCG10 (Novus Biologicals #NBP1–49461 1:500), α-Myelin Basic Protein (Bio Legend #808401 1:500), α-ATP8A2 (Invitrogen #PA5 −65256 1:500) and/or

(3) AhR inhibition promotes axon regeneration via a stress–growth switchNatureApril 1, 2026Dalia Halawani, Yiqun Wang, Jiaxi Li, Daniel Halperin, Haofei Ni, Molly Estill, Aarthi Ramakrishnan, Li Shen, Arthur Sefiani, Cédric G. Geoffroy, et al.(D71G9, rabbit, 1:300, Cell Signaling, 5568S, AB_10694505), anti-SCG10/STMN2 (rabbit, 1:1,000, Novus, NBP1-49461, AB_10011569), anti-GFP (chicken, 1:1,000, Aves Lab, GFP-1020, AB_10000240), anti-IBA1 (rabbit, 1:1,000,

(4) Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative programbioRxivFebruary 26, 2026Matthew Nolan, Sandeep Aryal, I. Sandra Ndayambaje, Maize Cao, Peyton Lee, Moriah Hovde, Shuqi Yun, Josette Wlaschin, Aaron Held, Hortense Beaussant, et al.Prolong Diamond Antifade Mountant (Invitrogen #P36970). Primary Antibodies: anti-STMN2 (Novus Biologicals #NBP1–49461, 1:1000), anti-VAChT (Synaptic Systems #139105, 1:500), anti-ATF3 (Santa Cruz #sc-81189, 1:250). Multiplexed

(5) AxoMetric platform facilitates rapid and unbiased automated quantification of axon regeneration in tissue sectionsCell Reports MethodsFebruary 23, 2026Matthew C. Finneran, Tara Rahmani, Ismaël Valentin Salioski, Ligia B. Schmitd, Ryan Passino, Craig N. Johnson, Roman J. Giger0.1% Triton X-100/PBS for 1 h. Sections were incubated with rabbit α-STMN2/SCG10 (Novus Biologicals, NBP1-49461, RRID:AB_10011569, 1:2,000) in blocking buffer overnight at 4°C in a humidified chamber. The next day,

(6) Acutely denervated muscle EVs reshape neuronal mitochondrial metabolism via retrograde signaling to rescue peripheral nerve injuryCell Reports MedicineFebruary 17, 2026Qi Liu, Borui Xue, Yongfeng Zhang, Mingze Qin, Ziqing Zhu, Zhenguo Wang, Hongyu Li, Shuanshuan Fan, Meijia Su, Shengyou Li, et al.anti-S100 beta,Abcam,Cat#ab52642; RRID: AB_882426 Stathmin-2/STMN2 Antibody,Novus biologicals,Cat#NBP1-49461; RRID: AB_10011569 "Mouse Anti-Neurofilament (Medium, 160 kD) Monoclonal Antibody, Unconjugated, Clone

(7) A tabletop blast device for the study of the long-term consequences of traumatic brain injury on brain organoidsCell Reports MethodsNovember 17, 2025Riccardo Sirtori, Akash Pandey, Arun Shukla, Claudia FalliniCaspase 3, rabbit",Cell Signaling Technology,9664S; RRID:AB_2070042 "STMN2, rabbit",Novus Biologicals,NBP1-49461; RRID:AB_10011569 "UNC13A, rabbit",Proteintech Group,68483-1-Ig; RRID:AB_3085194 "HDGFL2, rabbit",Proteintech Group

(8) AxoMetric: A Rapid and Unbiased Tool for Automated Quantification of Axon Regeneration in Tissue SectionsbioRxivJuly 3, 2025Matthew C. Finneran, Tara Rhamani, Ismaël Valentin Salioski, Ligia B. Schmitd, Ryan Passino, Craig N. Johnson, Roman J. GigerTriton-x-100/PBS for 1 hour. Sections were incubated with rabbit α-STMN2/SCG10 (Novus Biologicals, NBP1-49461, RRID:AB_10011569, 1:2000) in blocking buffer overnight at 4°C in a humidified chamber. The next day,

(9) Transforming growth factor beta–related proteins promote axonal regeneration of injured dorsal root ganglion neuronsNeural Regen ResMay 6, 2025Yinying Shen, Peng Yang, Wenyu Dai, Xiaosong Gu, Sheng Yisections were immunostained with the primary antibody rabbit anti-stathmin-2/STMN2 (SCG10; 1:500, Cat# NBP1-49461, RRID: AB_10011569; Novus Biologicals, Denver, CO, USA) for 18 hours at 4°C, followed by the secondary

(10) Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAsNucleic acids researchJune 10, 2022Patel P, Buchanan CN, Zdradzinski MD, Sahoo PK, Kar AN, Lee SJ, Vaughn LS, Urisman A, Oses-Prieto J, Dell'Orco M, et al.anti-KHSRP (Novus Biologicals, #NBP1-18910), and rabbit anti-Stathmin-2/SCG10 (1:500; Novus Biologicals, #NBP1-49461). Stathmin-2/SCG10 immunofluorescence was used to detect regenerating mouse sciatic nerve axons (36).

(11) Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neuronsCell reportsSeptember 7, 2021Cheng YC, Snavely A, Barrett LB, Zhang X, Herman C, Frost DJ, Riva P, Tochitsky I, Kawaguchi R, Singh B, et al.against ATF3 (Santa Cruz Biotech; sc-188; 1:1000), TRPV1 (Alomone; ACC-030; 1:1000), SCG10 (Novus; NBP1-49461; 1:2000), 53BP1 (Novus; NB100-304; 1:2000), chicken polyclonal antibody against NF200 (Millipore, AB5539;

(12) An Intrinsic Epigenetic Barrier for Functional Axon RegenerationNeuronApril 19, 2017Weng YL, An R, Cassin J, Joseph J, Mi R, Wang C, Zhong C, Jin SG, Pfeifer GP, Bellacosa A, et al.SNL D3 and postfixed with 4% PFA. Longitudinal sections were stained with SCG10 (Novus Biologicals, NBP1–49461). SCG10 fluorescence intensity was measured by NIH ImageJ along the distance as previously described

(13) Injury-induced HDAC5 nuclear export is essential for axon regenerationCellNovember 7, 2013Cho Y, Sloutsky R, Naegle KM, Cavalli V.

(14) Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve InjuryeNeuroJanuary 1, 0001"Girouard MP, Simas T, Hua L, Morquette B, Khazaei MR, Unsain N, Johnstone AD, Rambaldi I, Sanz RL, Di Raddo ME, et al."

(15) Dysregulated miR-29a-3p/PMP22 Modulates Schwann Cell Proliferation and Migration During Peripheral Nerve RegenerationMolecular neurobiologyJanuary 1, 0001"Shen Y, Cheng Z, Chen S, Zhang Y, Chen Q, Yi S."

(16) Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transectionDevelopmental cellJanuary 1, 0001"Nogueira-Rodrigues J, Leite SC, Pinto-Costa R, Sousa SC, Luz LL, Sintra MA, Oliveira R, Monteiro AC, Pinheiro GG, Vitorino M, et al."

(17) Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repairNeuronJanuary 1, 0001"Au NPB, Wu T, Chen X, Gao F, Li YTY, Tam WY, Yu KN, Geschwind DH, Coppola G, Wang X, et al."

(18) Sustained GSK3 activity markedly facilitates nerve regenerationNature communicationsJanuary 1, 0001"Gobrecht P, Leibinger M, Andreadaki A, Fischer D."

(19) Dual leucine zipper kinase is required for retrograde injury signaling and axonal regenerationNeuronJanuary 1, 0001"Shin JE, Cho Y, Beirowski B, Milbrandt J, Cavalli V, DiAntonio A."

(20) "Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury"Neurobiology of diseaseJanuary 1, 0001"Valakh V, Frey E, Babetto E, Walker LJ, DiAntonio A."

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