Fig 1: 127aa inhibits the transcription of NK-activating factors.A circSpdyA knocking out cells were established and subjected to RNA sequence, GESA analysis was applied concerning the NK activating factor, and the activating factor was listed. B The FPKM of each activating factor in the RNA sequence. C The relative SAM level in cells with indicated modifications. D The immunoblot detects NK cell activating factors in cells with indicated modifications. E BSP analysis was applied to detect the methylation level of the promoter of MICA and MICB, the illustration image was presented. F The statistical analysis of the methylation of the promoters. G The engagement of DNMT1 on the promoter of MICA and MICB in cells with indicated modifications. H–J DNA methylation inhibitor 5-Azacytidine was applied to treat cells. The methylation rate was determined. The relative RNA level was detected and the BSP analysis was applied.