Anti-RAS (G12D Mutant) antibody [HL10] GTX635362 from GeneTex

Product Specs
ItemAnti-RAS (G12D Mutant) antibody [HL10]
CompanyGeneTex
Price $419.00Supplier Page
Catalog NumberGTX635362
Quantity100 µl
ApplicationsWB, IHC-P
Concentration1.5mg/ml
Conjugate/TagUnconjugated
FormatPBS, No preservatives
PurityAffinity purified by Protein A
ReactivityHuman, Mouse
TargetRAS (G12D Mutant)
IsotypeIgG
CloneHL10
HostRabbit
Antibody TypePrimary Antibodies
ClonalityMonoclonal
Research AreaCancer, Metabolism, Tumor Markers
ImmunogenCarrier-protein conjugated synthetic peptide surrounding mutant G12D of human K-Ras. The exact sequence is proprietary
ModificationsMutant

Questions and Answers

Can this antibody be used to detect the G12D mutant form of RAS in extracellular vesicles?

Yes, the Anti-RAS (G12D Mutant) antibody [HL10] has been utilized in studies to detect the KRASG12D protein, particularly in the context of tumor-derived extracellular vesicles, as indicated in recent research that highlights its application in profiling EV protein biomarkers.

What species does this antibody work with?

The Anti-RAS (G12D Mutant) antibody [HL10] is reactive with both human and mouse proteins, making it suitable for experiments involving these species.

In what types of applications has this antibody been validated?

This antibody has been validated for use in Western Blotting, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry, allowing for versatile applications in cell biology and cancer research.

Are there any specific studies that have cited the use of this antibody?

Yes, the antibody has been cited in a study that discusses its application in the eSimoa framework for detecting and quantifying KRASG12D proteins in pancreatic tumor-derived extracellular vesicles, showcasing its relevance in cancer biomarker research.

GeneTex

GeneTex, Inc. 2456 Alton Parkway

Irvine, California 92606

United States

Phone: 1-877-GeneTex (436-3839) or 949-553-1900
Fax: 949-309-2888

Company Profile

Website: http://www.genetex.com

(1) Construction and application of a genetically engineered mouse model of gastric adenocarcinomaJournal of the Chinese Medical AssociationMarch 1, 2026Yelizhati Madeti, Xiaoyi Chong, Xiaotian ZhangHER2 (#2165) (all from CST, Boston, MA), annexin A10 (#66869, Proteintech, Wuhan, China), KrasG12D (#GTX635362, GeneTex, Irvine, CA), and Claudin18 (#AB203563, Abcam, Waltham, MA). The sections were treated with

(2) Construction and application of a genetically engineered mouse model of gastric adenocarcinomaJ Chin Med AssocFebruary 3, 2026Yelizhati Madeti, Xiaoyi Chong, Xiaotian ZhangHER2 (#2165) (all from CST, Boston, MA), annexin A10 (#66869, Proteintech, Wuhan, China), KrasG12D (#GTX635362, GeneTex, Irvine, CA), and Claudin18 (#AB203563, Abcam, Waltham, MA). The sections were treated with

(3) Amplifying mutational profiling of extracellular vesicle mRNA with SCOPENature BiotechnologySeptember 1, 2025Jayeon Song, Mi Hyeon Cho, Hayoung Cho, Younseong Song, Sung Woon Lee, Ho Chul Nam, Tae Ho Yoon, Jong Cheol Shin, Jae-Sang Hong, Yejin Kim, et al.Research Core at Massachusetts General Hospital for staining: hematoxylin and eosin (H&E), and RAS G12D (GTX635362, GeneTex; 25× dilution). Tissue from colorectal cancer patients. IHC was performed on representative

(4) Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1NeoplasiaAugust 1, 2025Audrey Lafargue, Hailun Wang, Sivarajan T. Chettiar, Rajendra P. Gajula, Amol C. Shetty, Yang Song, Brian W. Simons, Muhammad Ajmal Khan, Triet Nguyen, Hwai-Wei Tseng, et al.Cell Signaling Technology (RRID: SCR_002071), 1:2000), TWIST1 (2C1a, #sc-81417, Santa-Cruz Biotechnology, 1:100), RasG12D (#GTX635362, Genetex (RRID:SCR_000069), 1/75), p21 (#ab188224, Abcam (RRID:SCR_012931), 1/1000), p53 (#ab131442,

(5) Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 MutationsCancer DiscoveryJuly 3, 2025Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, et al.RRID:AB_561402). Other antibodies: KRAS (LSBio, LS-C175665; RRID:AB_2920760), RAS (G12D Mutant) (GeneTex, GTX635362; RRID:AB_2888515), RAS (mutated Q61) (Abcam, ab222516; RRID: AB_3674962), NRAS (Santa Cruz Biotechnology,

(6) Direct inhibition of RAS reveals the features of oncogenic signaling driven by RAS G12 and Q61 mutationsCancer DiscovJuly 3, 2025Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, et al.RRID:AB_561402). Other antibodies: KRAS (LSBio, LS-C175665; RRID:AB_2920760), RAS (G12D Mutant) (GeneTex, GTX635362; RRID:AB_2888515), RAS (mutated Q61) (Abcam, ab222516; RRID: AB_3674962), NRAS (Santa Cruz Biotechnology,

(7) CRIPTO's multifaceted role in driving aggressive prostate cancer unveiled by in vivo, organoid, and patient dataOncogeneMarch 1, 2025Rodrigues Sousa E, de Brot S, Zoni E, Zeinali S, Brunello A, Scarpa M, De Menna M, La Manna F, Abey Alexander A, Klima I, et al.(Cell Signaling, 4691-S), NKX3.1 (Cell Signaling, 83700T), EGFP (Abcam, ab13970), K-RASG12D (GeneTex, GTX635362)(Supplementary Table 6). The membranes were incubated with the same 1:1000 primary antibody concentration

(8) KRAS(G12D)-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDACCell reports. MedicineFebruary 18, 2025Jiang X, Wang T, Zhao B, Sun H, Dong Y, Ma Y, Li Z, Wu Y, Wang K, Guan X, et al.

(9) Identification of cold tumor induction-related markers in pancreatic cancer and the clinical implication of PCDH7Journal of cancer research and clinical oncologyJanuary 24, 2025Mochida Y, Ohuchida K, Zhang B, Yamada Y, Tsutsumi C, Kubo A, Oyama K, Shinkawa T, Iwamoto C, Torata N, et al.

(10) Orthotopic Models Using New, Murine Lung Adenocarcinoma Cell Lines Simulate Human Non-Small Cell Lung Cancer Treated with ImmunotherapyCellsJune 28, 2024Knott EP, Kim EY, Kim EQ, Freire R, Medina JA, Wang Y, Chen CB, Wu C, Wangpaichitr M, Conejo-Garcia JR, et al.

(11) Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras(G12D)-driven tumorsEMBO molecular medicineMarch 1, 2024Santofimia-Castaño P, Fraunhoffer N, Liu X, Bessone IF, di Magliano MP, Audebert S, Camoin L, Estaras M, Brenière M, Modesti M, et al.

(12) Ultrasensitive and High-Resolution Protein Spatially Decoding Framework for Tumor Extracellular VesiclesAdvanced science (Weinheim, Baden-Wurttemberg, Germany)January 1, 2024Cheng CA, Hou KC, Hsu CW, Chiang LC.anti‐TSG101 (1:1000, GTX118736, GeneTex), anti‐RAS (1:1000, GTX132480, GeneTex), anti‐KRASG12D (1:1000, GTX635362, GeneTex), and anti‐beta Actin (1:10000, GTX109639, GeneTex). Secondary antibodies include goat anti‐rabbit

(13) Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancerScience advancesApril 22, 2022Ferguson S, Yang KS, Zelga P, Liss AS, Carlson JCT, Del Castillo CF, Weissleder R.AF555, anti-G12V KRAS (Cell Signaling, 14412BF, special carrier-free order), and anti-G12D (Genetex, GTX635362), both labeled with AF594 using the Alexa Fluor 594 Antibody Labeling Kit from Thermo Fisher Scientific,

Be the First to Write a Review!

Anti-RAS (G12D Mutant) antibody [HL10]

Anti-RAS (G12D Mutant) antibody [HL10]

Anti-RAS (G12D Mutant) antibody [HL10]

Anti-RAS (G12D Mutant) antibody [HL10] from GeneTex

Description

Questions and Answers

GeneTex

Citations (13)

Reviews

Anti-RAS (G12D Mutant) antibody [HL10] from GeneTex

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map