CDC37 (D11A3) XP ® Rabbit mAb 4793S from Cell Signaling Technology

Product Specs
ItemCDC37 (D11A3) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number4793S
Quantity100 µl
ApplicationsW, IP, IF-IC
ReactivityH, M, R, Mk
TargetCDC37
HostRabbit
NCBI Gene AliasesP50CDC37
ClonalityMonoclonal
NCBI Full Gene Namecell division cycle 37, HSP90 cochaperone
Research AreaProtein Folding and Trafficking
CloneD11A3
Molecular Weight50

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Cell Signaling Technology

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(1) Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissuesThe EMBO JournalOctober 29, 2025Dominik Saul, Diana Jurk, Madison L Doolittle, Robyn Laura Kosinsky, Yeaeun Han, Xu Zhang, Ana Catarina Franco, Sung Y Kim, Saranya P Wyles, Y S Prakash, et al.,Experimental models Recombinant DNA,Recombinant DNA,Recombinant DNA Antibodies,Antibodies,Antibodies P16,Ventana,725-4793 P21,Cell Signaling,2947S Oligonucleotides and other sequence-based reagents,Oligonucleotides and other

(2) Matrix stiffness induces endothelial network senescencebioRxivOctober 8, 2025Jiyeon Song, Alexandra N. Rindone, Ya Guan, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerechtwere stained with the following antibodies in blocking buffer at RT: p16 for 15 min (CINTEC-Roche, 705–4793, 1:5), Notch1 for 30 min (Cell Signaling, 3608, 1:200), and CD31 for 30 min (Abcam, ab76533, 1:100).

(3) Ginsenoside Rg5 enhances Abemaciclib sensitivity in ER+ breast cancer by modulating cell cycle proteins via transcriptional and post-translational levelsJournal of Ginseng ResearchJune 28, 2025Jie Chen, Dongxu Liao, Chong Wu, Liangquan Liu, Jing Luo, Gang Li, Lei Caocyclin D1 (1:5000, 60186-1-Ig, Proteintech), HSP90 (1:2000, 13171-1-AP, Proteintech), CDC37 (1:1000, #4793, CST), β-actin (1:5000, 20536-1-AP, Proteintech) and GAPDH (1:5000, 10494-1-AP, Proteintech). Following

(4) Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffoldTheranosticsJanuary 6, 2025Xiaoyu Wan, Jiajun Yap, Junjun Chen, Yifan Li, Regina Faruk, Nazereth Chor Boon Tan, Yiying Ma, Yiting Lim, Karlina Bte Jubri, Jingyi Hu, et al.include: anti-phospho-ERK1/2 (#4370), anti-phospho-CRAF (Ser259) (#9421), anti-CRAF (#9422), anti-Cdc37 (#4793), and anti-14-3-3 (#8312) anti-ARAF (#4432) (Cell Signaling Technology); anti-HA (MAB6875, Novus Biologicals),

(5) Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative DisordersBiomedicinesJune 4, 2024Bay S, Digwal CS, Rodilla Martín AM, Sharma S, Stanisavljevic A, Rodina A, Attaran A, Roychowdhury T, Parikh K, Toth E, et al.Farmingdale, NY, USA; SRA-1500, RRID:AB_10618972, 1:2000), and CDC37 (Cell Signaling, Danvers, MA, USA; 4793, RRID:AB_10695539, 1:3000), followed by incubation with appropriate horseradish peroxidase (HRP)-conjugated

(6) Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of ActionBiomedicinesSeptember 22, 2023Sahil Sharma, Suhasini Joshi, Teja Kalidindi, Chander S. Digwal, Palak Panchal, Sang-Gyu Lee, Pat Zanzonico, Nagavarakishore Pillarsetty, Gabriela Chiosis1:8000) from Abcam (Cambridge, UK), HOP (ADI-SRA-1500; RRID:AB_10618972; 1:1000) from Enzo and CDC37 (4793S; RRID:AB_10695539; 1:1000) from Cell Signaling (Danvers, MA, USA). Membranes were then incubated with

(7) Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylationThe Journal of biological chemistryAugust 1, 2023Gu W, Zheng H, Canessa CM.(#2577), NDRG1(#9395), Phospho-NDRG1-Thr346 (#3217), Phospho-NEDD4L-Ser448 (#8063), Hsp90 (#4877), CDC37(#4793), HA Tag (#3724), and FLAG Tag (#14793) were from Cell Signaling Technology. Phospho-SGK1-S422 (#44-1264G),

(8) Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machineryCell reportsJuly 25, 2023Backe SJ, Sager RA, Heritz JA, Wengert LA, Meluni KA, Aran-Guiu X, Panaretou B, Woodford MR, Prodromou C, Bourboulia D, et al.,Cell Signaling Technology,Catt# 5670; RRID:AB_10828378 Rabbit anti-Cdc37,Cell Signaling Technology,Catt# 4793; RRID:AB_10695539 Rabbit anti-Ulk1,Cell Signaling Technology,Catt# 8054; RRID:AB_11178668 Rabbit anti-LC3B,Cell Signaling Technology

(9) Rational design, synthesis and structural characterization of peptides and peptidomimetics to target Hsp90/Cdc37 interaction for treating hepatocellular carcinomaComputational and structural biotechnology journalJanuary 1, 2023Sukumaran S, Tan M, Ben-Uliel SF, Zhang H, De Zotti M, Chua MS, So SK, Qvit N.antibodies against MEK1/2 (cat# 9122) and p-MEK1/2 (s217/221, cat# 9154), Hsp90 (cat# 4877 S), Cdc37 (cat# 4793 S) (all antibodies from Cell Signaling, Danvers, MA, USA). Antibody against the internal control, GAPDH

(10) Copper Modulates the Catalytic Activity of Protein Kinase CK2Frontiers in molecular biosciencesJanuary 1, 2022Chojnowski JE, Li R, Tsang T, Alfaran FH, Dick A, Cocklin S, Brady DC, Strochlic TI.#55561, Santa Cruz), mouse anti-PTEN (1:500 in BSA, #7974, Santa Cruz), mouse anti-CDC37 (1:1000 in BSA, #4793, Cell Signaling), mouse anti-GST (1:2000 in BSA, #138, Santa Cruz), rabbit anti-ERK (1:1000 in BSA,

(11) Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancerCommunications biologyNovember 25, 2021Joshi S, Gomes ED, Wang T, Corben A, Taldone T, Gandu S, Xu C, Sharma S, Buddaseth S, Yan P, et al.(ab2928; RRID:AB_303423; 1:6,000) and HSP70 (ab94368; RRID:AB_10716913; 1:5,000) from Abcam; CDC37 (4793; RRID:AB_10695539; 1:1,000) and HOP (5670; RRID:AB_10828378; 1:500), from Cell Signaling Technology. Epichaperome

(12) Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous systemNature communicationsAugust 3, 2021Bolaender A, Zatorska D, He H, Joshi S, Sharma S, Digwal CS, Patel HJ, Sun W, Imber BS, Ochiana SO, et al.Pgp, also called multi-drug resistance protein 1 (MDR1) (12683; RRID:AB_2715689; 1:1000) and CDC37 (4793; RRID:AB_10695539; 1:2,000) from Cell Signaling Technology; HSP70 (ADI-SPA-810; RRID:AB_10616513; 1:2,000),

(13) Differences in Extracellular Vesicle Protein Cargo Are Dependent on Head and Neck Squamous Cell Carcinoma Cell of Origin and Human Papillomavirus StatusCancersJuly 23, 2021Goudsmit C, da Veiga Leprevost F, Basrur V, Peters L, Nesvizhskii A, Walline H.,Santa Cruz,SC-398832,D2519,Mouse HLA-A,EP1395Y,Abcam,ab52922,GR25873,Rabbit HPV16 E7,N/A,Santa Cruz,SC-65711,I1216,Mouse p16,N/A,Ventana,725-4793,E04025,Mouse p53,DO-1,Neomarkers,MS-187-p,187p1201E,Mouse Rb,1F8,Neomarkers,MS-107-p1,107p1607F,Mouse STAT3,124H6,Cell Signaling

(14) Identification of microRNAs that promote erlotinib resistance in non-small cell lung cancerBiochemical PharmacologyJuly 1, 2021A.S. Pal, M. Bains, A. Agredo, A.L. Kasinskicells hsa-miR-5693,4.806839,hsa-miR-5693,6.980146 hsa-miR-3618,4.128858,hsa-miR-432-5p,5.680975 hsa-miR-3657,3.53778,hsa-miR-3618,5.201033 hsa-miR-432-5p,3.447473,hsa-miR-4787-5p,3.098385 hsa-miR-4435,3.369496,hsa-miR-3198,2.666229 hsa-miR-588,3.115648,hsa-miR-4435,2.599998 hsa-miR-4701-3p,3.096875,hsa-miR-588,2.331268 hsa-miR-4787-5p,2.550594,hsa-miR-4693-5p,2.305733 hsa-miR-4521,2.406701,hsa-miR-4797-5p,2.231674 hsa-miR-4499,2.176414,hsa-miR-4775,2.208845 hsa-miR-9-5p,2.139334,hsa-miR-4521,2.115477 hsa-miR-4643,2.074379,hsa-miR-4643,2.072277 hsa-miR-4486,1.758585,hsa-miR-4781-3p,1.938728 hsa-miR-548ac,1.743734,hsa-miR-4757-5p,1.797722 hsa-miR-4757-5p,1.71694,hsa-miR-4328,1.77053 hsa-miR-3926,1.614334,hsa-miR-4638-3p,1.730049 hsa-miR-4760-5p,1.552469,hsa-miR-4329,1.706815 hsa-miR-4748,1.508298,hsa-miR-4634,1.588003 hsa-miR-4792,1.494049,hsa-miR-4499,1.475899 hsa-miR-3198,1.474083,hsa-miR-4791,1.467733 hsa-miR-5694,1.472514,hsa-miR-4792,1.452575 hsa-miR-4778-5p,1.463761,hsa-miR-3665,1.405999 hsa-miR-4638-3p,1.358205,hsa-miR-4701-3p,1.387164 hsa-miR-3677-5p,1.339528,hsa-miR-4753-3p,1.364724 hsa-miR-4794,1.313135,hsa-miR-4793-5p,1.352131 hsa-miR-4693-5p,1.313076,hsa-miR-4706,1.338108 hsa-miR-4797-5p,1.298536,hsa-miR-4698,1.306059 hsa-miR-4328,1.276663,hsa-miR-4488,1.281768 hsa-miR-4753-3p,1.207611,hsa-miR-4778-5p,1.251342 hsa-miR-4781-3p,1.206249,hsa-miR-4740-3p,1.224541 hsa-miR-4488,1.182468,hsa-miR-4330,1.168158 hsa-miR-4740-3p,1.181966,hsa-miR-4748,1.116061 hsa-miR-548ab,1.140096,hsa-miR-3677-5p,1.110286 hsa-miR-4793-5p,1.126522,hsa-miR-4794,1.103088 hsa-miR-4634,1.121035,hsa-miR-4705,1.09914 hsa-miR-4705,1.119791,hsa-miR-4760-5p,1.035345 hsa-miR-4791,1.107927,hsa-miR-4728-5p,0.980355 hsa-miR-4706,1.104596,hsa-miR-548ak,0.893768 hsa-miR-4522,1.043842,hsa-miR-3926,0.810352 hsa-miR-4775,1.017418,hsa-miR-5694,0.804238 hsa-miR-548ak,0.971604,hsa-miR-9-5p,0.732981 hsa-miR-4468,0.943862,hsa-miR-548ac,0.313635 hsa-miR-3665,0.934691,hsa-miR-548ab,0.232357 hsa-miR-548aj-3p,0.926283,hsa-miR-4676-3p,0.222049 hsa-miR-4751,0.891378,hsa-miR-4654,0.120642 hsa-miR-4330,0.883232,hsa-miR-4661-3p,0.244 hsa-miR-4654,0.851533,hsa-miR-4741,0.065 hsa-miR-4661-3p,0.844637,hsa-miR-4516,−0.189 hsa-miR-4329,0.841927,hsa-miR-4751,0.040 hsa-miR-4698,0.837794,hsa-miR-204-3p,−0.128 hsa-miR-4799-3p,0.821699,hsa-miR-4690-3p,−0.318 hsa-miR-4728-5p,0.798065,hsa-miR-4486,−0.225 hsa-miR-4534,0.788234,hsa-miR-548ad,−0.360 hsa-miR-548ad,0.7357,hsa-miR-4468,−0.590 hsa-miR-4762-3p,0.661747,hsa-miR-4522,0.797 hsa-miR-4516,0.544357,hsa-miR-4762-3p,−0.248 hsa-miR-4741,0.529365,hsa-miR-3657,−0.908 hsa-miR-204-3p,0.424363,hsa-miR-548aj-3p,−0.128 hsa-miR-4690-3p,0.383958,hsa-miR-4799-3p,−1.572 hsa-miR-4676-3p,0.331065,hsa-miR-4534,−1.743 The

(15) Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell populationJCI insightApril 22, 2021DePianto DJ, Heiden JAV, Morshead KB, Sun KH, Modrusan Z, Teng G, Wolters PJ, Arron JR.Biologicals), KRT17 (AB183330, Abcam), Pro-SPC (AB3796, Chemicon), p16 (E6H4, Roche Tissue Diagnostics, 705-4793), Ki67 (D3B5, Cell Signaling Technology), and LY6D (PA5-64167, Thermo Fisher Scientific). Bulk RNA-Seq

(16) Coiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 DegradationFrontiers in oncologyJanuary 1, 2021Wang C, Li H, Wu L, Jiao X, Jin Z, Zhu Y, Fang Z, Zhang X, Huang H, Zhao L.(sc-1641) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Antibodies against CDC37 (4793S), cyclin E2 (4132S), HA (3724S), BTRC (11984S), and RXRα (3085S) were purchased from Cell Signaling Technology

(17) Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and ActivationMolecular cellAugust 6, 2020Lee SB, Ko A, Oh YT, Shi P, D'Angelo F, Frangaj B, Koller A, Chen EI, Cardozo T, Iavarone A, et al.1:1000 (#46687), phospho-CCND1 Thr-286 (#3300), cyclin D1 (#2978), AURKA 1:1000 (#14475), CDC37 1:1000 (#4793), HSP90 1:1000 (#4877), phospho-p38α MAPK 1(T180-Y182):1000 (#9211), p38α-MAPK 1:1000 (#8690), DYRK1A

(18) Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitisThe Journal of clinical investigationAugust 3, 2020Bulek K, Zhao J, Liao Y, Rana N, Corridoni D, Antanaviciute A, Chen X, Wang H, Qian W, Miller-Little WA, et al.following companies: NEDD4 (catalog 2740), caspase-8 (catalog 4790), Atg7 (catalog 8558), Cdc37 (catalog 4793), NLRP3 (catalog 15101), β-actin (catalog 3700) (all from Cell Signaling Technology), GSDMD (ab209845

(19) The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunctionNature communicationsJanuary 16, 2020Inda MC, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, Che AY, Taldone T, Yan P, Sun W, et al.(SPC-195) (Stressmarq); HSC70 (SPA-815) and HOP (SRA-1500) (Enzo); HSP90α (ab2928) Abcam; and CDC37 (4793) (Cell Signalling Technology). Epichaperome analysis Analyses of the epichaperome were performed as

(20) Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancerScience advancesSeptember 1, 2019Wang L, Zhang L, Li L, Jiang J, Zheng Z, Shang J, Wang C, Chen W, Bao Q, Xu X, et al.cell lysates was incubated with 5 μg of anti-Hsp90 (sc-13119, Santa Cruz Biotechnology), anti-Cdc37 (4793S, Cell Signaling Technology), or normal rabbit immunoglobulin G (IgG) (sc-2027, Santa Cruz Biotechnology)

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CDC37 (D11A3) XP ® Rabbit mAb

CDC37 (D11A3) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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CDC37 (D11A3) XP ® Rabbit mAb from Cell Signaling Technology

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