PKA C-alpha Antibody 4782S from Cell Signaling Technology

Product Specs
ItemPKA C-alpha Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number4782S
Quantity100 µl
ApplicationsW, IP, IF-IC, FC-FP
ReactivityH, M, R
TargetPKA C-alpha
Molecular Weight42
HostRabbit
NCBI Gene AliasesCAFD1, PKACA, PPNAD4
NCBI Full Gene Nameprotein kinase cAMP-activated catalytic subunit alpha
ClonalityPolyclonal
Research AreaCa, cAMP and Lipid Signaling

Questions and Answers

What species does this PKA C-alpha antibody work with in experiments?

The PKA C-alpha antibody has been shown to react with mouse, human, and rat samples, making it suitable for studies involving these species.

Can this antibody be used in studies related to cancer, and if so, how?

Yes, the PKA C-alpha antibody has been utilized in cancer research, particularly in studies investigating the role of protein kinase A in head and neck squamous cell carcinoma. It has been shown that PKA activation contributes to the malignant phenotype by phosphorylating NF-kappaB p65, which is involved in tumor progression ().

Is there any evidence of this antibody being used in signaling pathway studies?

Yes, the PKA C-alpha antibody has been employed in research examining the cAMP/PKA signaling pathways. For instance, it was used to demonstrate that ginsenoside Rg1 promotes neurite growth in retinal ganglion cells through the activation of these pathways ().

How has this antibody been applied in studies involving cellular stress responses?

The PKA C-alpha antibody has been referenced in studies exploring cellular responses to endoplasmic reticulum stress. Research indicated that PKA activation plays a protective role against apoptosis under conditions of unresolved ER stress, highlighting its significance in cellular survival mechanisms ().

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Microsomal triglyceride transfer protein restricts steroid production in Leydig cells by regulating SREBP2iScienceJune 19, 2026Atrayee Chattopadhyay, Munichandra Babu Babu Tirumalasetty, Thomas Palaia, Bhargavi Gangula, Rachel Ruoff, Qing Robert Miao, M. Mahmood HussainAB_2561044 Anti-phospho-CREB,Cell Signaling Technology,Cat# 9198S; RRID: AB_2561045 Anti-PKA-C,Cell Signaling Technology,Cat# 4782S; RRID: N/A Anti-phospho-PKA-C,Cell Signaling Technology,Cat# 5661S; RRID: N/A Anti-ERK1/2 (p44/42),Cell Signaling Technology

(2) Ethanolic Extract of Padina arborescens Suppresses Melanogenesis and Attenuates UVB-Induced Photodamage in Cellular and Zebrafish ModelsInt J Mol SciApril 9, 2026Yun-Su Lee, Wook-Chul Kim, Kyeong Min Lee, Seo-Rin Jung, Seung Tae Im, Min-Cheol Kang, Seung-Hong LeeUSA). Antibodies against phosphorylated PKA catalytic subunit (Thr197) (p-PKA C, #4781), total PKA C-α (#4782), phosphorylated CREB (Ser133) (p-CREB, #9198), total CREB (#9197), and MITF (D3B4T, #97800) were purchased

(3) MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathwayCell Death DiscoveryMarch 25, 2026Stephanie Maher, Andrew Roe, Kieran Wynne, Vadim Zhernovkov, Melinda Halasz(Thr202/Tyr204) (#4370), Phospho-Akt (Ser473) (#4060), Akt (#9272), Phospho-PKA C (Thr197) (#4781), PKA C-α (#4782), Vinculin (#4650), CREB (#9197), Phospho-CREB (Ser133) (#9191), GAP43 (#8945), Tyrosine hydroxylase

(4) FAM83D facilitates EMT and metastasis of cervical cancer via interaction with GSK3β and inactivation of GSK3β/stabilization of Snail signalingBiology DirectMarch 25, 2026Jiaofeng Li, Fengtian Li, Xia Meng, Zhiling Yang, Zhengguang Li, Hualong Tang, Wanglong Zhu, Haoming Li, Xingqiang He, Xinyue Lin, et al.Phospho-AKT(Ser 473) were gained from Cell Signaling Technology (1:1000, 3195 S, 13116T, 5741T, 3879T, 4782, 4781, 4060, Cell Signaling Technology, Danvers, MA, USA). The relative expression of the proteins was

(5) Effect of Vitamin K Supplementation on Testosterone Production in a Rat Model of Late-Onset HypogonadismFoodsMarch 18, 2026Rui Murakami, Yusuke Ohsaki, Hikaru Ito, Hsin-Jung Ho, Afifah Zahra Agista, Yi-Fen Chiang, Ya-Ling Chen, Masamitsu Maekawa, Takuo Hirose, Kenshiro Hara, et al.Imaging System (Bio-Rad Laboratories). The antibodies used were anti-protein kinase A (PKA, cat. no. 4782; Cell Signaling Technology, Danvers, MA, USA; 1:1000) and anti-phospho PKA (cat. no. 4781; Cell Signaling;

(6) Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R SignalingAdvanced ScienceFebruary 1, 2026Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, et al.albumin (BSA) in 1×TBST for 1 h at room temperature. Primary antibodies as follows: PKA (Cell signaling, 4782, 1:1000), p‐PKA (Cell signaling, 5661, 1:500), MEK (Cell signaling, 8727, 1:1000), p‐MEK (Cell signaling,

(7) HIIT-induced lactate/GPR81 signaling with dual branches converging on ERK1/2 contributes to hippocampal synaptic remodeling and memory improvementFrontiers in Cell and Developmental BiologyJanuary 14, 2026Xuepeng Bian, Qinghui Shang, Lutao Zhu, Jun Liu, Min Wu, Jingjing Li, Shujie Louprimary antibodies overnight at 4 °C. GPR81, PA5-114741, Thermo; AC (55067-1-AP, Proteintech), PKA (4782S, CST), RAP1 (2399S, CST), PKC (SC-80 Santa), PLC (14247S, CST), Raf1 (9422S, CST), MSK1 (3489S, CST),

(8) Adenosine/A 2A R/PKA signaling regulates HO-1-mediated anti-inflammatory responses during Leishmania donovani infectionmBioJanuary 14, 2026Tapasi Das, Pronay Brahmachari, Anindita UkilPhospho-PKA C (Thr197) Antibody,Cell Signaling Technology,4781,"1:1,000","1:1,000" PKA C-α Antibody,Cell Signaling Technology,4782,"1:1,000","1:1,000" CREB1 Antibody (X-12),Santa Cruz Biotechnology,sc-240,"1:1,000","1:1,000" p-CREB-1

(9) Exploring the Link Between PACAP Signalling and Hyaluronic Acid Production in Melanoma ProgressionInt J Mol SciDecember 15, 2025Tibor Hajdú, Patrik Kovács, Éva Katona, Minh Ngoc Nguyen, Judit Vágó, Csaba Fillér, Róza Zákány, Gabriella Emri, Gábor Tóth, Dóra Reglődi, et al.Israel." Anti-DPP4,"rabbit, polyclonal",1:500,61408,"Cell Signaling, Danvers, MA, USA" Anti-PKA,"rabbit, polyclonal",1:800,4782,"Cell Signaling, Danvers, MA, USA" Anti-p-PKA,"rabbit, polyclonal",1:500,4781,"Cell Signaling, Danvers,

(10) An ATF3 Inducer Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease Through the AMPK and PKA PathwaysInt J Mol SciDecember 9, 2025Ching-Feng Cheng, Ruey-Bing Yang, Wen-Ting Chen, Jia-Fang Chung, Hui-Chen KuCell Signaling Technology), Phospho-p44/42 MAPK (ERK1/2) (#9101, Cell Signaling Technology), PKA C-α (#4782, Cell Signaling Technology), Phospho-PKA C (Thr197) (#4781, Cell Signaling Technology), p38 MAPK (#9212,

(11) Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmissionNature CommunicationsNovember 28, 2025You-Kyung Lee, Cong Xiao, Xiaoting Zhou, Le Wang, Meghan McReynolds, Zhiping Wu, Xian Han, Eric Purisic, Henry Kim, Xianting Li, et al.5675S), Sheep anti-RIβ (R&D, AF4177), Mouse anti-RIIα (BD, 612242), Rabbit anti-PKACα (Cell signaling, 4782S), Rabbit anti-p-PKACαT197 (Cell signaling, 5661S), Mouse anti-β-actin (Cell signaling, 3700S), Rabbit

(12) Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in miceEMBO Molecular MedicineNovember 26, 2025Menghao Shi, Yinsong Ye, Lizhi Hu, Yibo Yan, Shushu Jiang, Pengchao Wang, Fengcen Li, Mingfa Ai, Jinhui Huang, Ling Yang, et al.(Cell Signaling Technology, 9272, 1:1000), p-Akt (Cell Signaling Technology, 9271, 1:1000), PKA (Cell Signaling Technology, 4782, 1:1000), p-PKA Substrate (Cell Signaling Technology, 9624, 1:1000), P38 (Proteintech, 14,064-1-AP,

(13) High Glucose Aggravates Cerebral Ischemia/Reperfusion via Truncated NLRP3 ‐Mediated Hexokinase‐2 TranslocationCNS Neuroscience & TherapeuticsNovember 18, 2025Hengchang Zhang, Ruoyi Guo, Xiang Li, Yang Zhang, Lujun Zhou, Junjie Wang, Yudi Huang, Zengqiang Yuan, Lijuan Song, Yajin Liao1:1000 for Western blotting), anti‐β‐tubulin (#CW0265, CWBIO, 1:1000 for Western blotting), anti‐PKA (#4782, CST, 1:1000 for Western blotting). 2.6 Cell Lines and Culture BV2 microglial cells, immortalized

(14) Dual PDE4/10A inhibition restores CREB1 function and enhances neuronal resilience in models of alzheimer's diseaseAlzheimers Res TherOctober 27, 2025Xiaoli Rong, Xia Yao, Haohui Fang, Johns Saji, Yu Qian, Jia-Xuan Gu, Meng-Yuan Yang, Peng Wei, Cai-Rui Liu, Bin Chen, et al.(1:1000, Cell Signaling, 71,429), total tau(1:1000, Invitrogen, MA5-12,808), PKA (1:1000, Cell Signaling, 4782), BDNF (1:1000, Abcam, ab108319), Aβ (1:1000, Creative Biolabs, TAB-0809CLV), and β-actin (1:1000, Invitrogen,

(15) Melanoma cell adhesion molecule-positive mesenchymal stromal cells alleviate acute respiratory distress syndrome via nuclear factor kappa-B-mediated paracrine regulationWorld journal of stem cellsOctober 26, 2025Zhang YL, Wen DK, Wang SN, Tan Y, Ma HR.Cell Signaling Technology (MA, United States): Phospho-NF-κB (#3031), NF-κB (#8242), protein kinase A (PKA) (#4782), phospho-PKA (p-PKA) (#4781), cyclic-AMP response element-binding protein (CREB) (#9197), phospho-CREB

(16) Melanoma cell adhesion molecule-positive mesenchymal stromal cells alleviate acute respiratory distress syndrome via nuclear factor kappa-B-mediated paracrine regulationWJSCOctober 26, 2025Ya-Li Zhang, Ding-Ke Wen, Sheng-Nan Wang, Yi Tan, He-Ran MaCell Signaling Technology (MA, United States): Phospho-NF-κB (#3031), NF-κB (#8242), protein kinase A (PKA) (#4782), phospho-PKA (p-PKA) (#4781), cyclic-AMP response element-binding protein (CREB) (#9197), phospho-CREB

(17) A Dual-compartment Scaffolding Role for Receptor for Activate C Kinase 1 in Hepatic Glucagon Signaling and GluconeogenesisCellular and Molecular Gastroenterology and HepatologyOctober 20, 2025Cancan Lyu, Ling Yang, Songhai Chen9197), phospho-CREBS133 (no. 9198), AKT (no. 4685), phospho-AKTS473S473 (no. 4060), and PKAcα (no. 4782) were procured from Cell Signaling Technology; GADPH (sc-47724) from Santa Cruz Biotechnology; and mouse

(18) D1 / D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2The FEBS JournalSeptember 22, 2025Kevin Chua, Yee Song Chong, Sreedharan Sajikumar(Thr197) (1 : 1000, #4781; Cell Signaling Technology, Danvers, MA, USA), rabbit anti‐PKA Cα (1 : 1000, #4782; Cell Signaling Technology), rabbit antiphosphorylated‐p44/42 MAPK Thr202/Tyr204 (1 : 1000, #9101; Cell Signaling Technology

(19) PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunityScience AdvancesSeptember 5, 2025Shen Yang, Eugenio Santelli, Carlos G. Gonzalez, Wade T. Johnson, Irene V. Choi, Chuling Zhuang, Myungja Ro, Leigh-Ana M. Rossitto, I-Shing Yu, Shu-Wha Lin, et al.(Tyr783) (D6M9S), anti–PLC-γ (D9H10), anti–phospho-CREB (Ser133) (87G3), anti-CREB (48H2), anti-PKA Cα (4782), anti-CSK (C74C1), and anti–glyceraldehyde-3-phosphate dehydrogenase (D16H11) antibodies were from

(20) The cAMP-PKA signaling initiates mitosis by phosphorylating BoraNat CommunAugust 24, 2025Min Zhu, Shinan Zhou, Yingqi Zhang, Qinfu Chen, Xueying Yuan, Long Zhang, Haiyan Yan, Fangwei Wang(A11122, Invitrogen), GAPDH (14C10, Cell Signaling Technology/CST), Flag-tag (A01868, GenScript), PKA-Cα (4782, CST), PKA-Cβ (12232-1-AP, Proteintech), histone H3 (ab1791, Abcam), pan-phospho-Ser/Thr (AP0893, ABclonal),

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PKA C-alpha Antibody

PKA C-alpha Antibody from Cell Signaling Technology

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Cell Signaling Technology

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PKA C-alpha Antibody from Cell Signaling Technology

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