EGF Receptor (15F8) Rabbit mAb 4405S from Cell Signaling Technology

Product Specs
ItemEGF Receptor (15F8) Rabbit mAb
CompanyCell Signaling Technology
Price $336.00 Inquire
Catalog Number4405S
Quantity100 µl
ApplicationsW
ReactivityH
TargetEGFR
HostRabbit
NCBI Gene AliasesERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
ClonalityMonoclonal
NCBI Full Gene Nameepidermal growth factor receptor
Research AreaRTK
Clone15F8
Molecular Weight175

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Anthrax ET activates Rac1 and RTK signaling to induce F-actin reorganization and endothelial permeabilityiScienceNovember 21, 2025Prashant Jain, Annabel Guichard, Mahtab Moayeri, Saluja Kaduwal, Margot Mel de Fontenay, Ian Rousseau, Stephen H. Leppla, Ethan Bierovernight at 4°C. Primary antibodies for pIGF1Rβ (#3024S), IGF1Rβ (#3027S), pEGFR (#2234S), EGFR (#4405S), pAKT (#4060S), AKT (#9272S), pERK (#9101S), ERK (#9102S), pCFL1 (#3311S) and CFL1 (#3318S), were all

(2) Rare mutations at EGFR L747 position: molecular characteristics and superior response to afatinib in NSCLC patientsESMO OpenSeptember 1, 2025Y. Huang, L. Pang, J. Lao, P. Deng, F. Hao, C. Xu, L. Yang, W. FangERK1/2 with antibodies from Cell Signaling Technology (Danvers, MA) [pEGFR (#2234S, 1 : 1000), EGFR (#4405S, 1 : 1000), pERK (#9101S, 1 : 1000), ERK (#4695S, 1 : 1000)]. Blots were probed with antibodies against

(3) REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signalingCell communication and signaling : CCSFebruary 18, 2025Ren X, Teng Y, Xie K, He X, Chen G, Zhang K, Liao Q, Zhang J, Zhou X, Zhu Y, et al.Cell Signaling Technology), anti-phosphorylated EGFR (Y1068, #3777, Cell Signaling Technology), anti-EGFR (#4405, Cell Signaling Technology), anti-phosphorylated ERK (#4370, Cell Signaling Technology), or anti-ERK

(4) Loss of EGF receptor polarity enables homeostatic imbalance in epithelial-cell modelsMolecular biology of the cellNovember 1, 2023Carlin CR, Ngalula S.(pSer59),Rabbit,Invitrogen,PA5-105927 BIM (pSer69),Rabbit,CST,4585 E-cad,Mouse,BD Biosciences,61081 EGFR,Rabbit,CST,4405 EGFR (pTyr845),Rabbit,CST,6963 EGFR (pSer1046/47),Rabbit,CST,3777 EGFR (pTyr1173),Rabbit,CST,4407 ERK1/2,Rabbit,CST,9102 ERK1/2

(5) N6-isopentenyladenosine induces cell death through necroptosis in human glioblastoma cellsCell death discoveryApril 7, 2022Pagano C, Navarra G, Coppola L, Avilia G, Pastorino O, Della Monica R, Buonaiuto M, Torelli G, Caiazzo P, Bifulco M, et al.antibody,1:1000 PUMA,Santa Cruz Biotechnology (sc-377015); monoclonal anti-mouse antibody,1:1000 EGFR,Cell Signaling (#4405 S); monoclonal anti-rabbit antibody,1:1000 Caspase-3,Cell Signaling (#9662); monoclonal anti-rabbit

(6) EGFR transactivates RON to drive oncogenic crosstalkeLifeNovember 25, 2021Franco Nitta C, Green EW, Jhamba ED, Keth JM, Ortiz-Caraveo I, Grattan RM, Schodt DJ, Gibson AC, Rajput A, Lidke KA, et al.when blotting for EGFR-Δ998 antibody,Anti-EGFR (Rabbit monoclonal),Cell Signaling Technology,Cat# 4405 RRID:AB_331380,Clone 15 F8 WB (1:2000) antibody,Anti-EGFR PY1068 (Mouse monoclonal),Cell Signaling Technology

(7) The Yunnan national medicine Maytenus compound inhibits the proliferation of hepatocellular carcinoma (HCC) by suppressing the activation of the EGFR-PI3K-AKT signaling pathwayJournal of CancerApril 7, 2021Wen-Tao Zhao et al.membranes (Millipore, ISEQ00010). Then, the blots were probed with primary antibodies against EGFR (CST, #4405), p-EGFR (CST, #4407), PI3K (Abcam, ab189403), p-PI3K (Abcam, ab182651), AKT (Abcam, ab8932), p-AKT

(8) Vitamin D3 Metabolites Demonstrate Prognostic Value in EGFR-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic ResistanceCancers (Basel)March 13, 2020Tatiana Shaurova et al.pAKT(Ser473) (CST, 9271), E-cadherin (BDTransduction Laboratories, San Jose, CA, USA (BD), 610181), EGFR (CST, 4405), pEGFR (Tyr1068) (CS, 2234), pMAPK (ERK1/2) (Thr202/Tyr204) (CST, 9101), α-Tubulin (Millipore, 05-829),

(9) Anticancer effect of the traditional Chinese medicine herb Maytenus compound via the EGFR/PI3K/AKT/GSK3β pathwayTranslational Cancer ResearchSeptember 1, 2019Baozhen Zeng et al.temperature, then added primary antibody incubated for 15 h at 4 ℃. Primary antibodies: EGFR (CST, #4405), pEGFR (CST, #4407), PI3K (ab189403), pPI3K (ab182651), AKT (ab8932), pAKT (ab179463), GSK3β (CST,

(10) Adenovirus early region 3 RIDα protein limits NFκB signaling through stress-activated EGF receptorsPLoS pathogensAugust 1, 2019Zeng X, Carlin CR.(San Jose, CA) 554155 EEA1 Rabbit Abcam (Cambridge, MA) ab2900 EGFR Rabbit CST (Beverly, MA) 4405 EGFR (pSer1046/47) Rabbit CST 3777 EGFR (pTyr1173) Rabbit CST 4407 FLAG Mouse CST 8146 GAPDH Rabbit CST 5174 GST Rabbit Amersham

(11) microRNA‐211 promotes proliferation, migration, and invasion ability of oral squamous cell carcinoma cells via targeting the bridging integrator 1 proteinJournal of Cellular BiochemistryMarch 1, 2019Jiabao Zheng, Jiali Wang, Yunlong Jia, Tianxu Liu, Yuqing Duan, Xing Liang, Lihua Liu(1:1000). MEK (12671, D2R10), p‐MEK (16211, 166F8), ERK (12950, D3I5V), p‐ERK (14474, 197G2), EGFR (4405, 15F8), and p‐EGFR (2236, 1H12) were all purchased from Cell Signaling Technology, Inc. (CST, California);

(12) Mutational activation of the epidermal growth factor receptor down-regulates major histocompatibility complex class I expression via the extracellular signal-regulated kinase in non-small cell lung cancerCancer scienceJanuary 1, 2019Watanabe S, Hayashi H, Haratani K, Shimizu S, Tanizaki J, Sakai K, Kawakami H, Yonesaka K, Tsurutani J, Togashi Y, et al.Kyoto, Japan) before incubation overnight at 4°C with primary antibodies including those to EGFR (#4405), to phosphorylated EGFR (Tyr1068, #2234), to AKT (#9272), to phosphorylated AKT (Ser473, #9271), or

(13) Lycorine inhibits glioblastoma multiforme growth through EGFR suppressionJournal of experimental & clinical cancer research : CRJuly 17, 2018Shen J, Zhang T, Cheng Z, Zhu N, Wang H, Lin L, Wang Z, Yi H, Hu M.levels of in vivo xenografts that dissected from tumor-bearing mice for phospho-EGFR (#4404) and EGFR (#4405) were purchased from Cell Signaling Technology (Danvers, MA). Antibodies for human β-actin (ab115777),

(14) Oxymatrine Causes Hepatotoxicity by Promoting the Phosphorylation of JNK and Induction of Endoplasmic Reticulum Stress Mediated by ROS in LO2 CellsMolecules and cellsMay 31, 2018Gu LL, Shen ZL, Li YL, Bao YQ, Lu H.CST), CHOP (L63F7) Mouse mAb (#2895, CST), Bip (C50B12) Rabbit mAb (#3177, CST), Caspase-4 Antibody (#4405, CST), β–action (C4) (sc-47778, Santa Cruz) at a 1:1,000 dilution in blocking solution. After three

(15) EGFR expression is associated with cytoplasmic staining of CXCR4 and predicts poor prognosis in triple-negative breast carcinomasOncology LettersFebruary 1, 2017Rong-Hui Li, Wen-He Huang, Jun-Dong Wu, Cai-Wen Du, Guo-Jun Zhangrabbit monoclonal anti-EGFR (Cell Signaling Technology, Inc., Danvers, MA, USA; dilution 1:3,000; #4405) antibody. The following day, the membrane was gently washed in Tris-buffered saline with 0.1% Tween-20

(16) Andrographolide-induced apoptosis in human renal tubular epithelial cells: Roles of endoplasmic reticulum stress and inflammatory responseEnvironmental toxicology and pharmacologyJuly 1, 2016Gu LL, Zhang XY, Xing WM, Xu JD, Lu H.

(17) Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancerMolecular biology of the cellNovember 5, 2015Valley CC, Arndt-Jovin DJ, Karedla N, Steinkamp MP, Chizhik AI, Hlavacek WS, Wilson BS, Lidke KA, Lidke DS.l-glutamine. Antibodies against phosphorylated EGFR (clone 1H12, #2236S) and total EGFR (clone 15F8, #4405S) used for immunoblotting and immunofluorescence were from Cell Signaling Technology (Danvers, MA). Horseradish

(18) Paclitaxel induces apoptosis and reduces proliferation by targeting epidermal growth factor receptor signaling pathway in oral cavity squamous cell carcinomaOncology LettersOctober 1, 2015JING HU, N A ZHANG, RONGLIN WANG, FEI HUANG, GUANG LIwith primary monoclonal rabbit anti‑human antibodies against β ‑actin (#4970), p‑EGFR (#11862), EGFR (#4405), p‑ERK1/2 (#4370), ERK1/2 (#9102), p‑JNK (#4671), JNK (#9252), p‑p38 (#4511), p38 (#9212), Bcl‑2 (#2870),

(19) Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6International Journal of OncologyJuly 1, 2015YONG WEON YI, KYUSIC YOU, EDWARD JEONG BAE, SAHNG-JUNE KWAK, YEON-SUN SEONG, INSOO BAE

(20) HE4 (WFDC2) gene overexpression promotes ovarian tumor growthScientific reportsJanuary 6, 2014Moore RG, Hill EK, Horan T, Yano N, Kim K, MacLaughlan S, Lambert-Messerlian G, Tseng YD, Padbury JF, Miller MC, et al.embedded SKOV-3 derived xenograft tissues were processed and stained with primary HE4, EGFR (cat no-4405; Cell Signaling, Danvers, MA) or HIF1α (cat no-13515; Santa Cruz biotechnology, Santa Cruz, CA) antibody

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EGF Receptor (15F8) Rabbit mAb

EGF Receptor (15F8) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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EGF Receptor (15F8) Rabbit mAb from Cell Signaling Technology

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