LIN28B Antibody 5422S from Cell Signaling Technology

Product Specs
ItemLIN28B Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number5422S
Quantity100 µl
ApplicationsW
ReactivityM
TargetLin28B
HostRabbit
NCBI Gene AliasesCSDD2
NCBI Full Gene Namelin-28 homolog B
ClonalityPolyclonal
Research AreaDevelopmental Biology
Molecular Weight32

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(1) Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic developmentNature CommunicationsNovember 26, 2025Zhihong Hao, Yi Wu, Yile Huang, Maolei Zhang, Yang Liu, Yueqiao Li, Wenxin Li, Zifeng Ruan, Jian Zhang, Yingzhe Ding, et al.anti-Actin (Huabio, ET1702-52, 1:5000), anti-Flag (Sigma, F1804, 1:1000), anti-Lin28b (Cell signaling, 5422S, 1:1000), anti-L1td1 (Proteintech, 21528, 1:1000) and anti-Tfcp2l1 (Proteintech, 14248, 1:1000). The

(2) Liver cancer initiation requires translational activation by an oncofetal regulon involving LIN28 proteinsThe Journal of clinical investigationJune 13, 2024Hsieh MH, Wei Y, Li L, Nguyen LH, Lin YH, Yong JM, Sun X, Wang X, Luo X, Knutson SK, et al.follows: NRAS (Abcam, AB77392, IHC), p-ERK (CST, 9101, IHC), LIN28B (Proteintech, 16178-1-AP or CST 5422, IHC and WB), LIN28A (CST, 8641, IHC), c-MYC (MilliporeSigma, M4439, IHC), RPS5 (Abcam, AB210745, WB),

(3) Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver diseaseNature communicationsDecember 26, 2022Lekka E, Kokanovic A, Mosole S, Civenni G, Schmidli S, Laski A, Ghidini A, Iyer P, Berk C, Behera A, et al.Cell Signaling; 1:1000), anti-Lin28b (#4196, Cell Signaling; 1:1000), anti-Lin28b (mouse preferred) (#5422, Cell Signaling; 1:1000), anti-insulin receptor beta (sc-57342, Santa Cruz; 1:1000), anti-total-Akt

(4) Lin28 paralogs regulate lung branching morphogenesisCell reportsJuly 20, 2021Osborne JK, Kinney MA, Han A, Akinnola KE, Yermalovich AV, Vo LT, Pearson DS, Sousa PM, Ratanasirintrawoot S, Tsanov KM, et al.RRID:AB_1236471 anti-rabbit Lin28a,Cell Signaling,#A177 RRID AB_2297060 anti-mouse specific Lin28b,Cell Signaling,cat#5422S; RRID:AB_10697489 anti-rabbit α/β tubulin,Cell Signaling,cat#2148S anti-mouse Ecadherin,Novex (Life Technologies

(5) MicroRNA‑379‑5p suppresses renal fibrosis by regulating the LIN28/let‑7 axis in diabetic nephropathyInternational Journal of Molecular MedicineAugust 30, 2019Nan Li, Li‑Juan Wang, Wei‑Long Xu, Su Liu, Jiang‑Yi Yuab2413; 1:1,000), p21 (ab109199; 1:1,000), cyclin D1 (ab134175; 1:1,000) (all from Abcam) and LIN28B (#5422; 1:1,000; Cell Signaling Technology). GAPDH (ab9485; 1:2,000; Abcam) was served as the loading control.

(6) Lin28 and let-7 regulate the timing of cessation of murine nephrogenesisNature communicationsJanuary 11, 2019Yermalovich AV, Osborne JK, Sousa P, Han A, Kinney MA, Chen MJ, Robinton DA, Montie H, Pearson DS, Wilson SB, et al.anti-Lin28a (1:1000, Cell Signaling, #3978), anti-Lin28b (1:1000, mouse preferred) (Cell Signaling, #5422), anti-Six2 (1:1000, Proteintech Group, #11562-1-AP). Uncropped scans included in Supplementary Figure

(7) C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in miceCommunications biologyJanuary 1, 2019Ackermann T, Hartleben G, Müller C, Mastrobuoni G, Groth M, Sterken BA, Zaini MA, Youssef SA, Zuidhof HR, Krauss SR, et al.B40941) and the anti-LIN28B antibody was used in a concentration of 1:100 (Cell Signaling Technology, # 5422S). Skin sections were stained with DAPI and mounted with non-hardening mounting medium. Images were taken

(8) Lin28 Signaling Supports Mammalian PNS and CNS Axon RegenerationCell reportsSeptember 4, 2018Wang XW, Li Q, Liu CM, Hall PA, Jiang JJ, Katchis CD, Kang S, Dong BC, Li S, Zhou FQ.,Cell Signaling Technology,Cat#3978S; RRID: AB_2297060 Rabbit polyclonal anti-Lin28b (mouse preferred),Cell Signaling Technology,Cat#5422S; RRID: AB_10697489 Rabbit polyclonal anti-hLin28b,Cell Signaling Technology,Cat#4196S; RRID: AB_2135047 Rabbit

(9) Chiglitazar Preferentially Regulates Gene Expression via Configuration-Restricted Binding and Phosphorylation Inhibition of PPARγPPAR ResearchSeptember 19, 2017De-Si Pan et al.

(10) Lin28B promotes Müller glial cell de-differentiation and proliferation in the regenerative rat retinasOncotargetAugust 2, 2016Zui Tao, Chen Zhao, Qian Jian, Mark Gillies, Haiwei Xu, Zheng Qin Yin,Santa Cruz Biotechnology,1:200/1:1000,Rabbit,sc-11357,IF/WB SOX2,Abcam,1:300/1:1000,Rabbit,ab97959,IF/WB Lin28B,Cell Signaling,1:1000,Mouse,5422S,WB GS,Millipore,1:600,Mouse,Mab302, GFAP,Abcam,1:800/1:1000,Rabbit,ab48050-100,IF/WB Rhodopsin,Abcam,1:300,Mouse,ab81702,IF PKC-α,Abcam,1:500,Mouse,Ab32376,IF Brdu,Cell Signaling

(11) Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depressionTranslational PsychiatryAugust 1, 2016Y B Wei, J J Liu, J C Villaescusa, E Åberg, S Brené, G Wegener, A A Mathé, C Lavebratttemperature. Immunoblotting was performed overnight at 4 °C with a polyclonal rabbit anti-LIN28B antibody (1:500 dilution; #5422, Cell Signaling Technology, Danvers, MA, USA) or with a polyclonal goat anti-DROSHA antibody (1:1000 dilution;

(12) MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cellsOncotargetMarch 22, 2016Min Xu et al.(Cell Signaling, CAT 8641), rabbit anti-MeCP2 (Cell Signaling, CAT 3456), mouse anti-LIN28B (Cell Signaling, CAT 5422), mouse anti-β-Tubulin (Cell Signaling, CAT 6181), rabbit anti-OCT4 (Cell Signaling, CAT 2840), rabbit

(13) Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathwayMolecular Medicine ReportsOctober 1, 2015ZHIMING ZHAO, CHENGGANG LI, HAO XI, YUANXING GAO, DABIN XUInc.), anti‑rabbit B‑cell‑associated X protein (Bax) antibody (1:1,000; MOLECULAR MEDICINE REPORTS 12: 5415-5422, 2015 cat. no. 5023; Cell Signaling Technology, Inc.), anti‑rabbit FoxO1 antibody (1:1,000; cat. no.

(14) The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochleaProceedings of the National Academy of Sciences of the United States of AmericaJuly 21, 2015Golden EJ, Benito-Gonzalez A, Doetzlhofer A.Membranes were blocked in 10% BSA in TBST and immunoblotted: rabbit antiLin28b 1:1,000 (Cell Signaling no. 5422), mouse anti-β-actin 1:3,000 (Ambion no. AM4302), rabbit anti-Flag 1:1,000 (Cell Signaling no. 2368).

(15) LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humansGenes & developmentMay 15, 2015Tu HC, Schwitalla S, Qian Z, LaPier GS, Yermalovich A, Ku YC, Chen SC, Viswanathan SR, Zhu H, Nishihara R, et al.anti-Lin28a (#3978, Cell Signaling), anti-LIN28B (#4196, Cell Signaling), anti-Lin28b (mouse preferred) (#5422, Cell Signaling), anti-Flag (M2 clone, Sigma), anti-Cyclin D1 (ab10540, Abcam), and anti-Sox 9 (AB5535,

(16) Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine modelsCancer cellAugust 11, 2014Nguyen LH, Robinton DA, Seligson MT, Wu L, Li L, Rakheja D, Comerford SA, Ramezani S, Sun X, Parikh MS, et al.Biolabs, #NC9029229). Antibodies used: anti-Lin28a (Cell Signaling, #8641), anti-Lin28b (Cell Signaling, #5422), anti-Ki-67 (Abcam, #15580), anti-Phospho-H3 (Cell Signaling, #9706), anti-Cleaved Caspase-3 (Cell Signaling

(17) Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis modelPloS oneJanuary 1, 2013Yoshikawa T, Otsuka M, Kishikawa T, Takata A, Ohno M, Shibata C, Kang YJ, Yoshida H, Koike K.Anti-c-Myc (sc-40) and anti-DICER (sc-30226) were purchased from Santa Cruz Biotechnology. Anti-LIN28B (5422), anti-PTEN (9559), and anti-β-catenin (9582) were purchased from Cell Signaling Technology (Danvers,

(18) Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesisOncogeneJanuary 1, 0001"Liu S, Tackmann NR, Yang J, Zhang Y."

(19) A Rapid Induction Mechanism for Lin28a in Trophic ResponsesMolecular cellJanuary 1, 0001"Amen AM, Ruiz-Garzon CR, Shi J, Subramanian M, Pham DL, Meffert MK.",Santa Cruz Biotechnology,Cat#sc-30226; RRID: AB_639122 Rabbit polyclonal anti-Lin28b,Cell Signaling Technology,Cat#5422; RRID: AB_10697489 Mouse monoclonal anti-c-Myc,Sigma-Aldrich,Cat#M4439; RRID: AB_439694 Rabbit polyclonal

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LIN28B Antibody (Mouse Preferred)

LIN28B Antibody from Cell Signaling Technology

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Cell Signaling Technology

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LIN28B Antibody from Cell Signaling Technology

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