SCD1 (R347) Antibody 2283S from Cell Signaling Technology

Product Specs
ItemSCD1 (R347) Antibody
CompanyCell Signaling Technology
Price $350.00 Inquire
Catalog Number2283S
Quantity100 µl
ApplicationsW, IF-IC
ReactivityH, M
TargetSCD
HostRabbit
NCBI Gene AliasesFADS5, MSTP008, SCD1, SCDOS, hSCD1
NCBI Full Gene Namestearoyl-CoA desaturase
ClonalityPolyclonal
Research AreaMetabolism
CloneR347
Molecular Weight37

Questions and Answers

Can this antibody be used to study necroptosis in my experiments?

Yes, the SCD1 (R347) Antibody has been utilized in studies related to necroptosis. For instance, it has been referenced in research examining the role of receptor-interacting protein kinase 3 (RIPK3) in necroptosis, where the antibody was used for Western blot analysis to detect RIPK3 levels in various cell death contexts ().

Is this antibody effective for detecting SCD1 in human and mouse samples?

The SCD1 (R347) Antibody is reactive to both human and mouse samples, making it suitable for studies involving these species. It has been shown to detect endogenous levels of total SCD1 protein in various applications, including Western blotting and immunocytochemistry ().

What applications has this antibody been successfully used in?

The SCD1 (R347) Antibody has been successfully used in several applications, including Western blotting, immunocytochemistry, and immunofluorescence. These applications allow for the visualization and quantification of SCD1 protein levels in different experimental setups ().

Are there any specific experimental conditions or treatments where this antibody has been cited?

Yes, the antibody has been cited in studies investigating the effects of interferons on necroptosis and cell cycle regulation. For example, it was used in experiments assessing the impact of cell cycle arrest on necroptosis, highlighting its relevance in understanding cell death mechanisms in response to various treatments ().

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) A viable kinase-inactive RIPK3 D143N mouse model reveals its scaffold function in driving TNF-induced inflammatory disorderCell Death DiscoveryFebruary 24, 2026Yayun Du, Jingjing Li, Cong Zhao, Shouqiao Hou, Qiuye Li, Xiangping Xu, Zhanhui Li, Jiaying Qiu, Changyu Zhuang, Lifen Xie, et al.were used: mouse p-RIPK1 (53286, CST), RIPK1 (610459, BD), mouse p-RIPK3 (91702, CST), mouse RIPK3 (2283, Prosci), human RIPK3(13526, CST), mouse p-MLKL(ab196436, abcam), mouse MLKL (AP14272b, abgent), Fl-Caspase-3

(2) Discovery of Zharp1-163 as a dual inhibitor of ferroptosis and necroptosis for the treatment of inflammatory disorders and kidney injuryCell Death DiscovAugust 28, 2025Yuting Ji, Shujing Du, Jingjing Li, Haikuo Ma, Xinhui Wang, Yongjin Hao, Zhanhui Li, Haohao Lu, Hao Liu, Chengkui Yang, et al.anti-human-phospho-RIPK3 monoclonal antibody (Abcam, ab209384), anti-mouse-RIPK3 monoclonal antibody (Prosci, 2283), anti-mouse-phospho-RIPK3 monoclonal antibody (Cell Signaling, #91702), anti-human-MLKL monoclonal

(3) Stress granule-mediated ZBP1 activation drives necroptotic cell death in non-obstructive azoospermia and testicular agingProceedings of the National Academy of Sciences of the United States of AmericaAugust 19, 2025Lei H, Li D, Chen J, Du B, Jiang K, Xu T, Han H, Fan W, Tian L, Wang X.(#44590S, Cell Signaling; IHC, 1:100), Cleaved Caspae3 (#9661L, Cell Signaling; IHC, 1:100), anti-RIPK3 (#2283, ProSci; WB, 1:1000; IHC, 1:100), anti-Mouse-RIPK3 (#95702, Cell Signaling; WB, 1:1000), anti-MLKL (ab255747;

(4) Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathwaysProceedings of the National Academy of Sciences of the United States of AmericaMarch 11, 2025Evdokimova M, Feng S, Caobi A, Moreira FR, Jones D, Alysandratos KD, Tully ES, Kotton DN, Boyd DF, Banach BS, et al.rabbit anti-pRIPK3 1:1,000 (CST 91702), rabbit anti-total RIPK3 (tRIPK3) 1:1,000 (ProSci Incorporated 2283), rabbit anti-pRIPK1 1:1,000 (CST 31122), rabbit anti-total RIPK1 (tRIPK1) 1:1,000 (CST 3493), mouse

(5) RIPK1 is required for ZBP1-driven necroptosis in human cellsPLoS biologyFebruary 1, 2025Amusan OT, Wang S, Yin C, Koehler HS, Li Y, Tenev T, Wilson R, Bellenie B, Zhang T, Wang J, et al.(13526, Cell Signaling, 1:1,000), phosphorylated RIPK3 (93654, Cell Signaling, 1:1,000), murine RIPK3 (2283, ProSci, 1:1,000), FLAG (20543, Proteintech, 1:2,000), ICP0 (sc-53070, Santa Cruz, 1:500), GAPDH (60004,

(6) TBK1 and IKKε protect target cells from IFNγ-mediated T cell killing via an inflammatory apoptotic mechanismbioRxiv : the preprint server for biologyAugust 8, 2024Sun ND, Carr AR, Krogman EN, Chawla Y, Zhong J, Guttormson MC, Chan M, Hsu MA, Dong H, Bogunovic D, et al.(Cell Signaling, 9661S), cleaved PARP (Cell Signaling, 9541S), FADD (Abcam, ab124812), RIPK3 (ProSci, 2283), phospho-MLKL (Ser345) (Cell Signaling, 62233S), MLKL (Millipore Sigma, MABC604), TNFR1 (Cell Signaling,

(7) Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of inflammatory cytokines during necroptosis stimulationCell Death & DiseaseAugust 8, 2024Sahil Yadav, Rayan El Hamra, Norah A. Alturki, Ardeshir Ariana, Avni Bhan, Kate Hurley, Matthias Gaestel, Perry J. Blackshear, Alexandre Blais, Subash Sad(Cell Signaling #83613), RipK1 (BD Biosciences #610459), p-RipK3T231/S232 (Cell Signaling #91702), RipK3 (ProSci #2283), p-MLKLS345 (Cell Signaling #37333), MLKL (Millipore Sigma #MABC604), p-MK2T334 (Cell Signaling #3007),

(8) ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs ExpressionAdvanced science (Weinheim, Baden-Wurttemberg, Germany)January 1, 2024Wu X, Wang Y, Chen B, Liu Y, Li F, Ou Y, Zhang H, Wu X, Li X, Wang L, et al.(610 459, BD Biosciences), anti‐phosphorylated RIPK1 (31122S, Cell Signaling Technology), anti‐RIPK3 (2283, Prosci), anti‐phosphorylated RIPK3 (ab195117, Abcam), anti‐MLKL (AP14272b, Abgent), anti‐phosphorylated

(9) Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosisJournal of Extracellular VesiclesOctober 8, 2023Benjamin Cappe, Mike Vadi, Eliza Sack, Ludivine Wacheul, Bruno Verstraeten, Sara Dufour, Julien Franck, Wei Xie, Francis Impens, An Hendrix, et al.sc‐7382, Santa Cruz), LAMP1 (L1418, Sigma‐Aldrich), phospho‐RIPK3 (E7S1R, 91702S, Cell Signalling), RIPK3 (2283, ProSci Incorporated), phospho‐MLKL (D6E3G, 37333S, Cell Signalling), MLKL (3H1, MABC604, Millipore),

(10) Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulationCell reportsOctober 4, 2022Wang Y, Karki R, Mall R, Sharma BR, Kalathur RC, Lee S, Kancharana B, So M, Combs KL, Kanneganti TD.RRID:AB_2799693" anti-tRIPK1,Cell Signaling Technology,"Cat# 3493, RRID:AB_2305314" anti-RIPK3,ProSci,"Cat# 2283, RRID:AB_203256" anti-pIRF3,Cell Signaling Technology,"Cat# 29047, RRID:AB_2773013" anti-tIRF3,Cell Signaling Technology

(11) Necroptosis is associated with Rab27‐independent expulsion of extracellular vesicles containing RIPK3 and MLKLJournal of Extracellular VesiclesSeptember 5, 2022Kartik Gupta et al.antibodies and dilutions used for Western blot analysis were as follows: anti‐RIPK3(1:1000, ProSci, Cat #:2283), anti‐RIPK3(1:1000, Cell Signaling Technology, Cat#:13526), anti‐MLKL (1:1000, EMD Millipore, Cat#MABC604),

(12) ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infectionScience immunologyAugust 26, 2022Karki R, Lee S, Mall R, Pandian N, Wang Y, Sharma BR, Malireddi RS, Yang D, Trifkovic S, Steele JA, et al.anti-cleaved caspase-8 (CST, #8592, 1:1000), anti-pRIPK3 (CST, #91702S, 1:1000), anti-RIPK3 (ProSci, #2283, 1:1000), anti-pMLKL (CST, #37333, 1:1000), anti-MLKL (Abgent, AP14272b, 1:1000), anti-GSDMD (Abcam,

(13) Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to prevent lymphopeniaCell death and differentiationAugust 1, 2022Li X, Li F, Zhang X, Zhang H, Zhao Q, Li M, Wu X, Wang L, Liu J, Wu X, et al.(610459, BD Biosciences), anti-phosphorylated RIPK1 (31122 S, Cell Signaling Technology), anti-RIPK3 (2283, Prosci), anti-phosphorylated RIPK3 (ab195117, Abcam), anti-caspase-8 (ALX-804-447-C100, Enzo Life Science),

(14) ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosisNatureJune 1, 2022Zhang T, Yin C, Fedorov A, Qiao L, Bao H, Beknazarov N, Wang S, Gautam A, Williams RM, Crawford JC, et al.(MABC60, EMD Millipore, 1:2000), total human MLKL (#14993, Cell Signaling Technology, 1:2000), RIPK3 (#2283, ProSci, 1:2000), FLAG (A00187, GenScript, 1:2000), MAVS (sc-365334, Santa Cruz Biotechnology, 1:1000),

(15) Salt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injuryCell death & diseaseFebruary 25, 2022Huang D, Chen P, Huang G, Sun H, Luo X, He C, Chen F, Wang Y, Zeng C, Su L, et al.Cell Signaling); anti-mRIPK1 S166 (31122, Cell Signaling); anti-hRIPK3 (13526, Cell Signaling); anti-mRIPK3 (2283, ProSci); anti-hRIPK3 S227 (91702, Cell Signaling); anti-mRIPK3 T231/S232 (91702, Cell Signaling); anti-hMLKL

(16) Integrated stress response restricts macrophage necroptosisLife science allianceJanuary 1, 2022Place DE, Samir P, Malireddi RS, Kanneganti TD.[CST], 1:1,000), MLKL (37705; CST, 1:1,000), phospho-RIPK3 (Thr231/Ser232) (91702; CST, 1:1,000), RIPK3 (2283; ProSci, 1:1,000), phospho-eIF2α (Ser51) (3398; CST, 1:1,000), eIF2α (9722; CST, 1:1,000), RIPK1 (3493;

(17) TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagyAutophagyDecember 1, 2021Wu W, Wang X, Sun Y, Berleth N, Deitersen J, Schlütermann D, Stuhldreier F, Wallot-Hieke N, José Mendiburo M, Cox J, et al.using proximity ligation assay as described in the material and methods section (anti-RIPK3: Prosci, 2283; anti-PRKAA1/2: Cell Signaling Technology, 2793). Nuclei were stained with DAPI. Signals and nuclei

(18) Diversity of cell death signaling pathways in macrophages upon infection with modified vaccinia virus Ankara (MVA)Cell death & diseaseOctober 28, 2021Klaas L, Vier J, Gentle IE, Häcker G, Kirschnek S.Laboratories, clone 38/RIP, #610459), phospho-RIPK1 (S166, Cell Signaling, #31122), RIPK3 (ProSci, #2283), mouse caspase-8 (Cell Signaling, #4927 and #9429), human caspase-8 (#9746, Cell Signaling), mouse

(19) AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defenceNatureSeptember 1, 2021Lee S, Karki R, Wang Y, Nguyen LN, Kalathur RC, Kanneganti TD.anti-cleaved caspase-8 (CST, #8592, 1:1000), anti-pRIPK3 (CST, #91702S, 1:1000), anti-RIPK3 (ProSci, #2283, 1:1000), anti-pMLKL (CST, #37333, 1:1000), anti-MLKL (Abgent, AP14272b, 1:1000), anti-GSDMD (Abcam,

(20) Deletion of TLR4 reduces apoptosis and improves histology in a murine kidney transplant modelScientific reportsAugust 10, 2021Jain S, Plenter R, Nydam T, Gill RG, Jani A.antibody for TLR4 (Cell Signaling, 2219), Cleaved caspase-8 (Cell Signaling, 8592), RIP3 (ProScience, 2283), phospho RIP3 (Cell Signaling, 57220), MLKL (Santa Cruz Biotech, sc-165025), phospho MLKL (Cell Signaling,

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SCD1 (R347) Antibody

SCD1 (R347) Antibody from Cell Signaling Technology

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SCD1 (R347) Antibody from Cell Signaling Technology

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