RPA70/RPA1 Antibody 2267S from Cell Signaling Technology

Product Specs
ItemRPA70/RPA1 Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number2267S
Quantity100 µl
ApplicationsW, IP, IF-IC, FC-FP
ReactivityH, Mk
TargetRPA1
HostRabbit
NCBI Gene AliasesHSSB, MST075, PFBMFT6, REPA1, RF-A, RP-A, RPA70
NCBI Full Gene Namereplication protein A1
ClonalityPolyclonal
Research AreaCell Cycle / Checkpoint Control
Molecular Weight70

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Interaction of NDRG1 and TGM2 modulates DNA replication and repairMolecular Cancer ResearchMarch 31, 2026Hanna M. Doh, Nina Kozlova, Kayla A. Cruz, Taru MuranenCST), ATR (#2790, CST), pChk1-S317 (#12302, CST), pChk1-S345 (#2348, CST), Chk1 (#2360, CST), RPA70 (#2267, CST), Cyclin E2 (#4132, CST), pH3 (#9701, CST). Appropriate secondary antibodies (peroxidase-conjugated

(2) Interaction of NDRG1 and TGM2 modulates DNA replication and repairMol Cancer ResMarch 31, 2026Hanna M. Doh, Nina Kozlova, Kayla A. Cruz, Taru MuranenCST), ATR (#2790, CST), pChk1-S317 (#12302, CST), pChk1-S345 (#2348, CST), Chk1 (#2360, CST), RPA70 (#2267, CST), Cyclin E2 (#4132, CST), pH3 (#9701, CST). Appropriate secondary antibodies (peroxidase-conjugated

(3) Integrative biology shows DPP4 affects inflammatory response to eclampsia and cell model growth via p65/NLRP3/ASC/Caspase-1 pathwayFront GenetMarch 4, 2026Zhimin Bian, Li Hao, Rongjuan Yang, Jianghui Sun(Cell Signaling Technology, Catalog No. 2118, United States), Caspase-1 (Cell Signaling Technology, Catalog No. 2267, United States), p-Caspase-1 (p17) (Cell Signaling Technology, Catalog No. 3866, United States), ASC

(4) MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signalingJournal of Clinical InvestigationMarch 2, 2026Fatmata Sesay, Hui Zhang, Priya Kapoor-Vazirani, Andrew T. Jung, Mark E. Essien, Amanda J. Bastien, Nho C. Luong, Xu Liu, PamelaSara E. Head, Duc M. Duong, et al.(Abcam, Ab6556), pan acetyl-Lys (Santa Cruz Biotechnology, sc-8649), RPA70 (Cell Signaling Technology, 2267), P-CHK2 T68 (Cell Signaling Technology, 2661S), CHK2 (Santa Cruz Biotechnology, sc-7898), P-KAP1 (Invitrogen,

(5) HAT1 as a Lactyltransferase to Promote DNA Repair Through RPA1 Lactylation in GlioblastomaInt J Biol SciJanuary 22, 2026Yuzu Zhao, Jiang He, Zhiying Zhou, Tangmin Lai, Siwei Zeng, Nan Li, Yu He, Wei Zhou, Yongzhong Wu, Bo XuH4K16la and H4 antibodies were purchased from PTM BIO (Hangzhou, China). γ-H2AX (#9718) and RPA1 (#2267) antibodies were purchased from Cell Signaling Technology (CST, Shanghai, China). For co-Immunoprecipitation,

(6) MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signalingJ Clin InvestJanuary 8, 2026Fatmata Sesay, Hui Zhang, Priya Kapoor-Vazirani, Andrew T. Jung, Mark E. Essien, Amanda J. Bastien, Nho C. Luong, Xu Liu, PamelaSara E. Head, Duc M. Duong, et al.(Abcam, Ab6556), pan acetyl-Lys (Santa Cruz Biotechnology, sc-8649), RPA70 (Cell Signaling Technology, 2267), P-CHK2 T68 (Cell Signaling Technology, 2661S), CHK2 (Santa Cruz Biotechnology, sc-7898), P-KAP1 (Invitrogen,

(7) Mechanism of RPA phosphocode priming and tuning by CDK1/WEE1 signaling circuitNat CommunDecember 9, 2025Poonam Roshan, Vikas Kaushik, Ayush Mistry, Abhinav Vayyeti, Aidan Antony, Riley Luebbers, Jaigeeth Deveryshetty, Edwin Antony, Sofia Origantiincubated with 20 μL protein A/G plus agarose beads and 1 μg of anti-RPA70 antibody (Cell Signaling, 2267) and rotated overnight at 4 °C. The next day, unbound lysate was removed by centrifugation at 3000 rpm

(8) HAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinomaCell Death & DiseaseNovember 21, 2025Jiang He, Tangmin Lai, Yuzu Zhao, Zhiying Zhou, Liu Zhou, Dan Tao, Haonan Yang, Nan Li, Yu He, Shuheng Yang, et al.Pan-Khib (#PTM-802) and Pan-Kac (#PTM-105RM) were purchased from PTM BIO. γ-H2AX (#9718) and RPA1 (#2267) were purchased from Cell Signaling Technology. RAD51 (#PA5-27195) was purchased from Thermo Fisher.

(9) CD137L promotes immune surveillance in melanoma via HLTF regulationNature CommunicationsSeptember 26, 2025Long Liang, Lin Zhu, Xin Li, Wenbin Zhou, Yanbin Zhang, Mien-Chie Hung, Guanxiong Zhang, Yong Chen, Xinwei Kuang, Juan Su, et al.immunoprecipitated by either control IgG or HLTF (2 μg), or Flag (14793, Cell Signaling Technology, 2 μg) or Myc (2267, Cell Signaling Technology, 4 μg) primary antibody. After washing and reverse cross-linking, the eluted

(10) RAD51 is chromatin enriched and targetable in BRCA1-deficient cellsMolecular cellSeptember 18, 2025Peng M, Lee S, Nair HG, MacGilvary N, Cong K, Kraemer M, Li R, McConnell J, Baer C, Deng B, et al.sc-271339), anti-RAD51 (Abcam63801), anti-phospho-H2AX (Millipore 05–636), anti-RPA70 (Cell Signaling #2267S), anti-PALB2 (Abcam 202970), anti-BRCA2 (Upstate 05666), anti-Vinculin (Abcam AB91459), anti-β-actin

(11) Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expressionPLoS PathogAugust 18, 2025Monnette F. Summers, MegAnn K. Haubold, Marcel Morgenstern, Phoenix Shepherd, Clairine I. S. Larsen, Ava E. Bartz, Gopishankar Thirumoorthy, Robert N. Kirchdoerfer, Joshua J. Coon, Kavi P. M. Mehta, et al.analysis: RPA14 (Life Technologies, MA1-23281), RPA32 (Cell Signaling, 52448S), RPA70 (Cell Signaling, 2267S), phospho-RPA32 Ser 8 (Cell Signaling, 83745), TFDP2 (Protein Tech, 11500-1-AP), PRIM1 (Protein Tech,

(12) Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELBNAR Molecular MedicineMay 23, 2025Bertha Osei, Benjamin H May, Joseph S Beard, Matthew D Thompson, Duah Alkam, Maroof Khan Zafar, Erik Bergstrom, Stephanie D Byrum, Eric J Enemark, Kirk L West, et al.Antibodies used were rabbit anti-HELB (Abcam: ab202141, 1:10000–1:5000), rabbit anti-RPA70 (Cell Signaling 2267S, 1:1000), mouse anti-β-actin (Cell signaling: 3700S, 1:2000) or hFAB rhodamine anti-β-actin (Bio-Rad:

(13) γ-tubulin mediates DNA double-strand break repairJournal of Cell ScienceMarch 15, 2025Abhishikt David Solomon, Odjo G. Gouttia, Ling Wang, Songli Zhu, Feifei Wang, Yanqui Li, Mohammadjavad Paydar, Tadayoshi Bessho, Benjamin H. Kwok, Aimin Peng#8875, 1:800), anti-DNA-PKcs (E6U3A, #38168, 1:1000), anti-Ku70 (D10A7, #4588, 1:1000), anti-RPA70 (#2267, 1:1000), anti-DNA ligase IV (D5N5N, #14649, 1:1000), anti pATM/ATR substrate (#6966, 1:1000) and anti-XLF

(14) Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerabilityNature CancerJanuary 21, 2025Jenna M. Whalen, Jillian Earley, Christi Silva, Arthur M. Mercurio, Sharon B. CantorAbcam, ab18192, 1:200 dilution; RAD51: Bioacademia, 70–001, 1:100 dilution; RPA70: Cell Signaling, 2267, 1:50 dilution; and 53BP1: Novus Biologicals, NB100–304, 1:500 dilution in PBS + 3% BSA) for 1 h at

(15) UBA1 inhibition sensitizes cancer cells to PARP inhibitorsCell reports. MedicineDecember 17, 2024Awasthi S, Dobrolecki LE, Sallas C, Zhang X, Li Y, Khazaei S, Ghosh S, Jeter CR, Liu J, Mills GB, et al.Cell Signaling Technology (Anti-Beta Actin #3700, Anti uH2B #5546, Anti Wee1 #13084T, Anti-PARP #9542, Anti-RPA1 #2267, HRP Anti-Mouse #7076 and HRP Anti-Rabbit #7074). Quantification and statistical analysis Details

(16) Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome FunctionMolecular cancer therapeuticsNovember 4, 2024Xiang S, Craig KC, Luo X, Welch DL, Ferreira RB, Lawrence HR, Lawrence NJ, Reed DR, Alexandrow MG.RRID:AB_2107436); from Cell Signaling (Danvers, MA): anti-RPA32 (2208s, RRID:AB_2238543), anti-RPA70 (2267s, RRID:AB_2180506), anti-Mcm3 (4003s, RRID:AB_2142261), anti-Lamin A/C (2032S, RRID:AB_2136278), anti-WRN

(17) The DNA double-strand break repair proteins γH2AX, RAD51, BRCA1, RPA70, KU80, and XRCC4 exhibit follicle-specific expression differences in the postnatal mouse ovaries from early to older agesJournal of Assisted Reproduction and GeneticsSeptember 1, 2024Gunel Talibova, Yesim Bilmez, Betul Tire, Saffet OzturkUSA), BRCA1 (diluted 1:1000; catalog no. bs-0803R, Bioss Inc.), and RPA70 (diluted 1:3000; catalog no. 2267S, Cell Signaling Technology), KU80 (diluted 1:250; catalog no. MBS712948, MyBiosource, Inc., San Diego,

(18) PARP trapping is governed by the PARP inhibitor dissociation rate constantCell Chemical BiologyJuly 18, 2024Angelica A. Gopal, Bianca Fernandez, Justin Delano, Ralph Weissleder, J. Matthew Dubach,Cell Signaling Technology,Cat#9715 GADPH antibody,R&D Systems,Cat#AF5718 RPA1 antibody,Cell Signaling Technology,Cat#2267 BRCA1 antibody,Thermo Fisher,Cat#MA1-23164 Dnk pAb to Goat IgG (HRP) antibody,Abcam,Cat#Ab97110 Anti-rabbit

(19) CSB and SMARCAL1 compete for RPA32 at stalled forks and differentially control the fate of stalled forks in BRCA2-deficient cellsNucleic acids researchMay 22, 2024Batenburg NL, Sowa DJ, Walker JR, Andres SN, Zhu XD.(1:2000; sc-47692, Santa Cruz); Myc (1:1000 for western, 1:2000 for IF; 9E10, Calbiochem); RPA70 (1:2000; 2267S, Cell Signaling); RPA32 (1:10000; NB100-332, Novus Biologicals); RPA32-pS4/pS8 (1:2000; A300-245A, Bethyl Laboratories

(20) Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting DrugsCancer ResearchApril 1, 2024Audrey Lumeau, Nicolas Bery, Audrey Francès, Marion Gayral, Guillaume Labrousse, Cyril Ribeyre, Charlene Lopez, Adele Nevot, Abdessamad El Kaoutari, Naima Hanoun, et al.1:1,000), anti–phospho-RPA2 (S4-S8; Bethyl A300–245A, 1:500), anti-RPA70 (Cell Signaling Technology #2267, 1:500), anti-FANCD2 (NOVUSBIO NB100–182, 1:1,000), and anti-53BP1 (Bethyl A300–272A, 1:2,500). DNA

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RPA70/RPA1 Antibody

RPA70/RPA1 Antibody from Cell Signaling Technology

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Cell Signaling Technology

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RPA70/RPA1 Antibody from Cell Signaling Technology

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