Rap1A/Rap1B (26B4) Rabbit mAb 2399S from Cell Signaling Technology

Product Specs
ItemRap1A/Rap1B (26B4) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2399S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, Mk, B
HostRabbit
ClonalityMonoclonal
TargetRap1A;Rap1B
NCBI Full Gene NameRAP1B, member of RAS oncogene family, RAP1A, member of RAS oncogene family
NCBI Gene AliasesC21KG, SMGP21, K-REV, RAP1, KREV1, KREV-1, RAL1B, G-22K
Research AreaCytoskeletal Signaling
Clone26B4
Molecular Weight21

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Peripheral lysosome levels dictate mTORC1 inactivation even when catabolically impairedCell Communication and SignalingJanuary 20, 2026Huy Quang Dang, Therése Forssén, Spyridon Pantelios, Aisegkioul Nteli Chatzioglou, Ewa Kurzejamska, C. Theresa Vincent, Yasir Ibrahim, Anders P. Mutvei(9234), S6K1 (2708), p-4E-BP1 Ser65 (9451), 4E-BP1 (9644), mTOR (2983), p-Akt S473 (4060), Rap1A + B (2399), Akt1 (2938), TSC2 (3302), Rab7 (2094). Other antibodies included: GCN2 (Novus Biologicals, MAB6878),

(2) HIIT-induced lactate/GPR81 signaling with dual branches converging on ERK1/2 contributes to hippocampal synaptic remodeling and memory improvementFrontiers in Cell and Developmental BiologyJanuary 14, 2026Xuepeng Bian, Qinghui Shang, Lutao Zhu, Jun Liu, Min Wu, Jingjing Li, Shujie Louovernight at 4 °C. GPR81, PA5-114741, Thermo; AC (55067-1-AP, Proteintech), PKA (4782S, CST), RAP1 (2399S, CST), PKC (SC-80 Santa), PLC (14247S, CST), Raf1 (9422S, CST), MSK1 (3489S, CST), P90RSK (9355S, CST),

(3) Atf3 Deficiency Promotes Mesodermal Commitment and Enhances Endothelial Differentiation in Embryonic Stem CellsArteriosclerosis, Thrombosis, and Vascular BiologyDecember 1, 2025Zongyue Jiang, Lide Su, Cuiting Chen, Ronghai He, LiLi Jiang, Yanyan Shu, Dandan Dai, Man Wu, Ailin Guo, Jianlei Liu, et al.(platelet/endothelial cell adhesion molecule 1; 3528S; Cell Signaling) and Rap1 (ras-related protein 1; 2399S; Cell Signaling) overnight at 4 °C. After washing with PBS containing 0.1% Tween-20, the membranes were

(4) Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signalingWorld Journal of Gastrointestinal OncologySeptember 15, 2025Yi-Jia Chen, Cheng Peng, Li-Wei Wang, Jia-Xin Chai, Jian-Dong Wang, Qi-Bin Hecontaining 5% nonfat dry milk, the membranes were incubated with primary rabbit anti-Rap1A/Rap1B (CST, 2399; diluted 1:500). The membranes were subsequently washed in TBST and incubated with an anti-rabbit secondary

(5) Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathwayFrontiers in PharmacologyMarch 20, 2025Shengnan Shi, Jiaming Gao, Yehao Zhang, Min Zhan, Zhanfei Tan, Peili Wang, Jianhua Fu, Jianxun Liup-PI3K(Proteintech, 66009-1-lg), PI3K(ZEN BIO, 341468), p-AKT (CST, 4060), AKT (CST, 9272), RAP1(CST, 2399) and β-actin (Abcam, ab8226) at 1:1000 and detected via chemiluminescence with an ECL Western blotting detection

(6) Multi-omics analyses reveal biological and clinical insights in recurrent stage I non-small cell lung cancerNat CommunFebruary 10, 2025Chengdi Wang, Jingwei Li, Jingyao Chen, Zhoufeng Wang, Guonian Zhu, Lujia Song, Jiayang Wu, Changshu Li, Rong Qiu, Xuelan Chen, et al.performed. The following antibodies were used: Anti-PRAME (Abcam, Ab219650), GAPDH (CST, 2118), Rap1 (CST,2399 s), mTOR (CST,2983 T), and PCNA (CST, 13110 s). Images were developed by NcmECL Ultra Reagent (NCM biotech). RNA

(7) Rap1A Modulates Store-Operated Calcium Entry in the Lung Endothelium: A Novel Mechanism Controlling NFAT-Mediated Vascular Inflammation and PermeabilityArteriosclerosis, Thrombosis, and Vascular BiologyNovember 1, 2024Ramoji Kosuru, Olivier Romito, Guru Prasad Sharma, Francesca Ferraresso, Behshid Ghadrdoost Nakhchi, Kai Yang, Tadanori Mammoto, Akiko Mammoto, Christian J. Kastrup, David X. Zhang, et al.against Orai1 (1:1000; Sigma-Aldrich; No. O8264), Rap1A/Rap1B (1:1000; Cell Signaling Technologies; No. 2399), and β-actin (1:1000; Santa Cruz Biotechnology; No. sc-47778). Horseradish peroxidase-conjugated secondary

(8) Buyang Huanwu decoction ameliorates myocardial injury and attenuates platelet activation by regulating the PI3 kinase/Rap1/integrin α(IIb)β(3) pathwayChinese MedicineAugust 19, 2024Jiaming Gao, Hao Guo, Junmei Li, Min Zhan, Yue You, Gaojie Xin, Zixin Liu, Xiaodi Fan, Qinghe Gao, Jianxun Liu, et al.Cambridge, UK), phospho-Akt serine/threonine kinase (p-Akt) (ab38449, Abcam, Cambridge, UK), Rap1(#2399, CST, Boston, USA), cell division cycle 42 (CDC42) (ab187643, Abcam, Cambridge, UK), nonreceptor tyrosine

(9) Cholesterol neutralized vemurafenib treatment by promoting melanoma stem-like cells via its metabolite 27-hydroxycholesterolCellular and molecular life sciences : CMLSMay 22, 2024Wang X, Zhong F, Chen T, Wang H, Wang W, Jin H, Li C, Guo X, Liu Y, Zhang Y, et al.with anti-DHCR24 (Santa Cruz Biotechnology, sc-398938), anti-Rap1A/Rap1B (Cell Signaling Technology, 2399), anti-AKT1 (Santa Cruz Biotechnology, sc-5298), anti-pAKT1-Thr308/309 (Signalway Antibody, 13311),

(10) Simvastatin Preferentially Targets FLT3/ITD Acute Myeloid Leukemia by Inhibiting MEK/ERK and p38-MAPK Signaling PathwaysDrugs in R&DDecember 1, 2023Genhong Li, Jingwei Yao, Zhen Lu, Lian Yu, Qinwei Chen, Lihong Ding, Zhihong Fang, Yin Li, Bing Xuanti-RhoB (Cell Signaling Technology, Inc.; #63876S), anti-Rap1 (Cell Signaling Technology, Inc.; #2399S), anti-MDR1(Cell Signaling Technology, Inc.; #13342), and antiphospho-MDM2 (Cell Signaling Technology,

(11) Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal AdenocarcinomaPharmaceuticals (Basel)September 28, 2022Keisuke Okuno, Caiming Xu, Silvia Pascual-Sabater, Masanori Tokunaga, Haiyong Han, Cristina Fillat, Yusuke Kinugasa, Ajay Goelincubated overnight at 4 °C with diluted primary antibodies. Primary antibodies against Rap1 (1:1000, #2399; Cell Signaling Technology [CST], Danvers, MA, USA), PI3K (1:500, #4249; CST), Akt (1:1000, #4691; CST),

(12) Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca(2+)-PPP3/calcineurin-TFEB axisAutophagyApril 1, 2022Zummo FP, Krishnanda SI, Georgiou M, O'Harte FP, Parthsarathy V, Cullen KS, Honkanen-Scott M, Shaw JA, Lovat PE, Arden C.Cell Signaling Technology, 2971), anti-MTOR (Cell Signaling Technology, 2972), anti-RAP1 (Cell Signaling Technology, 2399), anti-p-RPS6 (Ser240/244; Cell Signaling Technology, 2215), anti-RPS6 (Cell Signaling Technology, 2217)

(13) Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm IntegrityFrontiers in Cell and Developmental BiologyMarch 18, 2022Mee-Ling Maywald, Cara Picciotto, Carolin Lepa, Luisa Bertgen, Farwah Sanam Yousaf, Andrea Ricker, Jürgen Klingauf, Michael P. Krahn, Hermann Pavenstädt, Britta Georgewere diluted 1:1000 in 5% bovine serum albumin in TBST. The following antibodies were used: Rap1A/B (#2399S, Cell Signaling Technologies), nephrin (#BP5030, OriGene), p-nephrin (#ab80298, Abcam), HA (#11867423001,

(14) RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's diseaseNeuropathology and applied neurobiologyAugust 1, 2021Jang YN, Jang H, Kim GH, Noh JE, Chang KA, Lee KJ.S1). Antibodies against phospho‐p38 (#4511), p38 (#9212), phospho‐JNK (#9255), JNK (#9252), Rap1 (#2399) and β‐tubulin (#2146) were purchased from Cell Signaling Technology. The rabbit polyclonal GFP antibody

(15) Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic ApplicationsMoleculesMarch 11, 2021Sumedh Kamble, Peter Valtchev, Aiken Dao, Théophile Pelras, Michael J Rogers, Paul B. Savage, Fariba Dehghani, Aaron Schindelerantibodies that bind unprenylated Rap1A (Santa Cruz, sc1482) or prenylated Rap1A/B (Cell Signaling, 2399S) for 16 h at 4 °C, and LiCOR secondary antibodies (1/20,000 dilution anti-goat 680 RD, anti-rabbit 800

(16) Distinct Signaling Functions of Rap1 Isoforms in NO Release From EndotheliumFrontiers in cell and developmental biologyJanuary 1, 2021Kosuru R, Singh B, Lakshmikanthan S, Nishijima Y, Vasquez-Vivar J, Zhang DX, Chrzanowska M.#9574), total eNOS (Cell Signaling Technologies #32027), Rap1A/Rap1B (Cell Signaling Technologies #2399), and β-actin (Santa Cruz Biotechnology #sc-47778). Rap1 rabbit monoclonal antibody (clone 26B4, Cell

(17) Meta-Wearable Antennasâ€”A Review of Metamaterial Based Antennas in Wireless Body Area NetworksMaterials (Basel)December 31, 2020Kai Zhang, Ping Jack Soh, Sen YanAntenna Integrated With Artificial Magnetic Conductor. IEEE Antennas Wirel. Propag. Lett. 2017, 16, 2396–2399. [CrossRef]

(18) Association of self-regulation with white matter correlates in boys with and without autism spectrum disorderScientific ReportsDecember 1, 2020Hsing-Chang Ni, Hsiang-Yuan Lin, Wen-Yih Isaac Tseng, Susan Shur-Fen Gaubiotype in medication-naive adults with attention-deficit hyperactivity disorder. Psychol. Med. 48, 2399–2408. https://doi.org/10.1017/S0033291718000028 (2018). 113. Perry, A. et al. The independent influences

(19) Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesisNatureSeptember 1, 2020Palikuqi B, Nguyen DT, Li G, Schreiner R, Pellegata AF, Liu Y, Redmond D, Geng F, Lin Y, Gómez-Salinero JM, et al.nitrocellulose membranes. The following primary antibodies were used at the indicated dilutions: RAP1 (CST, 2399, 1:1,000); RASGRP3 (CST, 3334, 1:1,000), GAPDH (CST, 5174, 1:10,000); AKT (CST, 34685, 1:5,000); p-S473-AKT

(20) Kinetics of receptor tyrosine kinase activation define ERK signaling dynamicsScience signalingAugust 18, 2020Kiyatkin A, van Alderwerelt van Rosenburgh IK, Klein DE, Lemmon MA.(C67C8) (CST #4168), phospho-TrkA (pTyr785) (R&D #AF5479), TrkA (R&D #AF1056), Rap1A/Rap1B (26B4) (CST #2399), FRS2 (Fisher Sci #PA124685), phospho-ErbB4 (pTyr1242) (4C6) (Santa Cruz #sc81491), phospho-ErbB4 (pTyr1284)

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Rap1A/Rap1B (26B4) Rabbit mAb

Rap1A/Rap1B (26B4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Rap1A/Rap1B (26B4) Rabbit mAb from Cell Signaling Technology

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