SENP3 (D20A10) XP ® Rabbit mAb 5591S from Cell Signaling Technology

Product Specs
ItemSENP3 (D20A10) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number5591S
Quantity100 µl
ApplicationsW, IP, IF-IC
ReactivityH, M, R, Mk
TargetSENP3
HostRabbit
NCBI Gene AliasesSMT3IP1, SSP3, Ulp1
ClonalityMonoclonal
NCBI Full Gene NameSUMO specific peptidase 3
Research AreaUbiquitin and Ubiquitin-like proteins
IsotypeIgG
CloneD20A10
Molecular Weight75

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Cell Signaling Technology

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Website: http://www.cellsignal.com/

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(1) SENP3 drives colorectal cancer progression by enhancing GDF15 expressionInt J Colorectal DisMarch 13, 2026Yang Yu, Wenfang Bao, Jingde Chen, Yandong Li, Yong Gaoprimary antibody targeting SENP3 protein was commercially available from Cell Signaling Technology (5591S, MA, USA), and the primary antibody targeting GDF15 protein was purchased from Selleck (G3D13, China).

(2) SERPINB3 enhances NPM1 sumoylation via inhibiting SENP3’s activity and promotes lung tumorigenesisCell Death & DiseaseDecember 24, 2025Xiangyu Meng, Weize Wang, Namratha Sheshadri, Tianyu Zhang, Xinlu Han, Yifu Sun, Man Xiao, Yu Feng, Shan Gao, Jian Chen, et al.(1:500, Thermofisher, #PA5-30164). SENP3 antibody for WB and IF (1:1,000, Cell Signaling Technology, #5591); SENP3 antibody for IF (1:50, Santa Cruz Biotechnology, #SC-133149). NPM1 antibody for WB and IF (1:1,000,

(3) SENP3 promotes renal tubular epithelial cell apoptosis after ischemia-reperfusion injury via ASS1 deSUMOylationCell Death & DiseaseDecember 5, 2025Hongju Wang, Cui Gao, Jingjuan Yang, Lini Jin, Longlong Wu, Qian Zhang, Xin Fang, Hong Pan, Huijuan Wu, Pattarin Tangtanatakul, et al.permeabilized (0.5% Triton X-100), blocked (5% BSA), and incubated with primary antibodies (SENP3, #5591, CST; ASS1, 16210-1-AP, Proteintech; LTL, L32480, Invitrogen; P53, 60283-2-Ig, Proteintech) followed

(4) SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPLiScienceAugust 15, 2025Xinyuan Xiong, Yang Zhi, Nan Yang, Wenzhen Zhao, Shu Wang, Huiqin Zhu, Jieting Tang, Jing Yi, Xuxu Sun, Jie YangAnti-SENP2,Proteintech,Cat#29772-1-AP; RRID: AB_3086158 Rabbit monoclonal Anti-SENP3,Cell Signaling Technology,Cat#5591; RRID:AB_10694546 Rabbit Polyclonal Anti-SENP5,Proteintech,Cat#19529-1-AP; RRID: AB_10643377 Mouse

(5) SENP3 alleviates osteoporosis via promoting SIRT3 transcription through the increase of DLX2 stability via SUMO2/3Cell Biol ToxicolJune 10, 2025Jie Bu, Xuezheng Xu, Yi Luo, Jianfan Liu, Feng Zhoublock membranes. The protein bands were immunoblotted with specific primary antibodies: anti-SENP3 (#5591, Cell Signaling Technology, 1:1000), anti-DLX2 (ab272902, Abcam, 1:5000), anti-SUMO2/3 (#4971, Cell Signaling Technology

(6) Structural basis for the human SENP5's SUMO isoform discriminationNat CommunMay 22, 2025Lucía Sánchez-Alba, Li Ying, Matthew D. Maletic, Anna De Bolòs, Helena Borràs-Gas, Bing Liu, Nathalia Varejão, Virginia Amador, Monique P. C. Mulder, David Reverterroom temperature of primary antibody: rabbit anti-SENP3 (1:1000 dilution; Cell Signalling Technology; 5591) and mouse anti-β-actin (1:10000 dilution; Santa Cruz Biotechnology.; sc-47778). This was followed by

(7) Brucella NyxA and NyxB dimerization enhances effector function during infectionFEBS LettersMay 21, 2025Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo[1] Anti‐Nucleolin,Mouse,,1/100,"Invitrogen (Waltham, MA, USA) #39‐6400" Anti‐SENP3,Rabbit,1/1000,1/400,Cell Signaling #5591 List of antibodies used in this study.

(8) TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stressCell ReportsJanuary 28, 2025Sseu-Pei Hwang, Han Liao, Katherine Barondeau, Xinyi Han, Cassandra Herbert, Hunter McConie, Amirtha Shekar, Dimitri G. Pestov, Patrick A. Limbach, Jeffrey T. Chang, et al.Antibody,Sigma-Aldrich,Cat#SAB1408048; RRID: AB_10741695 Rabbit anti-SENP3 Antibody,Cell Signaling Technology,Cat#5591; RRID: AB_10694546 Rabbit anti-WDR18 Antibody,Castle et al.25,N/A Mouse anti-NPM1 Antibody,Santa Cruz Biotechnology

(9) SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxiaCell Death & DiseaseDecember 5, 2024Alice Zhao, Laura Maple, Juwei Jiang, Katie N. Myers, Callum G. Jones, Hannah Gagg, Connor McGarrity-Cottrell, Ola Rominiyi, Spencer J. Collis, Greg Wells, et al.(recombinant monoclonal Ab, Abcam EPR3844, 1:2,000 dilution), SENP3 (rabbit monoclonal Ab, Cell Signaling #5591, 1:10,000 dilution), SUMO1 (rabbit polyclonal Ab, Cell Signaling #4930; 1:1,000 dilution), SUMO2/3 (rabbit

(10) USP36 SUMOylates Las1L and Promotes Its Function in Pre–Ribosomal RNA ITS2 ProcessingCancer Research CommunicationsOctober 1, 2024Yanping Li, Yunhan Yang, Rosalie C. Sears, Mu-Shui Dai, Xiao-Xin Sun(A15875, ABclonal, RRID: AB_2763304), anti-TEX10 (17372-1-AP, Proteintech, RRID: AB_2201871), anti-SENP3 (5591, Cell Signaling Technology, RRID: AB_10694546), anti-RPL30 (s-98106, Santa Cruz Biotechnology, RRID:

(11) METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinomaJournal of Hematology & OncologySeptember 2, 2024Jialin Wang, Mengxi Xiu, Jin Wang, Yong Gao, Yandong Lifollowing proteins were obtained from Cell Signaling Technology (MA, USA): METTL16 (87538 S); SENP3 (5591 S); anti-rabbit IgG, HRP-linked Antibody (7074); anti-mouse IgG, HRP-linked Antibody (7076); Mouse (G3A1)

(12) SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1Redox biologySeptember 1, 2024Chen X, Wang J, Yang P, Liu HY, Zhong S, Lu C, Gao M, Liu D, Zhang J, Wang J, et al.mouse or rat wound sections were stained by antibodies against SENP3 (1:400; Cell Signaling Technology, 5591), F4/80 (1:100; Invitrogen, MA1-91124), CD68 (1:400; Abcam, ab955), AGR-1 (1:400; Cell Signaling Technology,

(13) Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylationCell Mol Life SciDecember 9, 2023Yangjing Jiang, Min Liang, Long Chen, Jian Wang, Yijie Huang, Huanhuan Huo, Danrui Xiao, Yunwen Hu, Zi Wang, Qingqi Ji, et al.HK112-9K) and incubated with primary antibodies against Senp3 (Cell Signaling Technology [CST]; Cat# 5591; 1:100) and YAP1 (CST, Cat# 14074, 1:100). Goat antirabbit/mouse IgG (DAKO, Cat# K4061, ready-to-use)

(14) SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functionsCell reportsApril 25, 2023Zhou H, Feng W, Yu J, Shafiq TA, Paulo JA, Zhang J, Luo Z, Gygi SP, Moazed D.,Cell Signaling Technology,Cat#13069S Anti-PHC2,Elabscience,Cat#E-AB-65051 Anti-SENP3,Cell Signaling Technology,Cat#5591S Anti-WDR18,Sigma,Cat#HPA050193; RRID:AB_2681047 Anti-USP7,Cell Signaling Technology,Cat#4833T Anti-NOL9,Sigma,Cat#SAB4301156 Anti-BMI1,Proteintech,Cat#10832-1-AP;

(15) Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophageImmunity, inflammation and diseaseFebruary 1, 2023Bao X, Liu B, Jiang Y, Feng T, Cao W, Shi J, Jiang Y, Chen X, Yang J, Li J, et al.1:2000 (Service, GB13067‐M‐2), CD206 antibody 1:200 (Service, GB11062), and SENP3 antibody 1:5000 (5591S, CST) overnight at 4°C in the dark. Subsequently, the specimens were incubated with horseradish peroxidase–labeled

(16) SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injuryInnate immunityJanuary 1, 2023He S, Fan C, Ji Y, Su Q, Zhao F, Xie C, Chen X, Zhang Y, Chen Y.1. Immunoblotting Immunoblotting was conducted as previously described[22]. Antibodies specific for SENP3 (5591) and PKM2 (4053) were used (Cell Signaling Technology, Danvers, MA, USA). The antibodies against HIF-1α

(17) Application of Condition Monitoring for Hydraulic Oil Using Tuning Fork Sensor: A Study Case on Hydraulic System of Earth Moving MachineryMaterials (Basel)October 31, 2022Hong-Gyu Jeon, Jong-Kyun Kim, Seon-Jun Na, Min-Seok Kim, Sung-Ho HongSampling(January 2022),2nd Oil Sampling(May 2022),3rd Oil Sampling(August 2022) Monitoring A,4495 h,4967 h,5591 h,5848 h Monitoring B,4697 h,5191 h,5808 h,6380 h Monitoring C,5450 h,6040 h,6700 h,7163 h Monitoring

(18) Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progressionCell death & diseaseApril 28, 2022Tong Y, Zhang Z, Cheng Y, Yang J, Fan C, Zhang X, Yang J, Wang L, Guo D, Yan D.purchased from Santa Cruz Biotechnology. Antibodies against c-Myc (#18583), SUMO2/3 (#4971 CST) and SENP3 (#5591) were obtained from Cell Signaling Technology. Antibodies against EGFR (D160292), cox2 (D223097), SENP1

(19) EAPB0503, an Imidazoquinoxaline Derivative Modulates SENP3/ARF Mediated SUMOylation, and Induces NPM1c Degradation in NPM1 Mutant AMLInternational journal of molecular sciencesMarch 22, 2022Skayneh H, Jishi B, Hleihel R, Hamie M, El Hajj R, Deleuze-Masquefa C, Bonnet PA, El Sabban M, El Hajj H.Thermo Fisher Scientific, Waltham, MA, USA), ARF (MA5-14,260, 1:200, Thermo Fisher Scientific, Waltham, MA, USA), SENP3 (5591, 1:1000, Cell Signaling, Danvers, MA, USA), P-p53 (Ser15) (9284, 1:1000, Cell Signaling, Danvers, MA,

(20) SENP3 loss promotes M2 macrophage polarization and breast cancer progressionMolecular oncologyFebruary 1, 2022Xiao M, Bian Q, Lao Y, Yi J, Sun X, Sun X, Yang J.Caspase 3 (Abcam, ab2302); anti‐mouse CD31 (Maixin, Shanghai, China); anti‐SENP3 (CST, Boston, CA, USA, 5591); anti‐CD206 (Abcam, ab64693). The secondary antibodies (1 : 200) were then incubated for 2 h. Sections

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SENP3 (D20A10) XP ® Rabbit mAb

SENP3 (D20A10) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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SENP3 (D20A10) XP ® Rabbit mAb from Cell Signaling Technology

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