Src (36D10) Rabbit mAb 2109S from Cell Signaling Technology

Product Specs
ItemSrc (36D10) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2109S
Quantity100 µl
ApplicationsW, W-S, IP, IHC-P, IF-F, IF-IC, FC-FP
ReactivityH, M, R, Hm, Mk, B, Pg
TargetSrc
HostRabbit
NCBI Gene AliasesASV, SRC1, THC6, c-SRC, p60-Src
ClonalityMonoclonal
NCBI Full Gene NameSRC proto-oncogene, non-receptor tyrosine kinase
Research AreaMAP Kinase Signaling
IsotypeIgG
Clone36D10
Molecular Weight60

Questions and Answers

Can this Src antibody be used to study its role in cancer-related platelet activation?

Yes, the Src (36D10) Rabbit mAb has been shown to be effective in studies investigating the mechanisms of tumor-platelet communications, particularly in the context of cancer-sourced small extracellular vesicles that activate platelets. This antibody was utilized to detect Src protein levels in murine and human platelets, highlighting its relevance in understanding platelet activation in cancer (Dudiki et al., 2023).

Is this antibody suitable for use in immunoprecipitation experiments?

The Src (36D10) Rabbit mAb is indeed suitable for immunoprecipitation applications. It has been cited in various studies, including those examining the phosphorylation of proteins involved in signaling pathways, indicating its utility in isolating Src and its interacting partners (Griaud et al., 2013; Tu et al., 2022).

What species can this antibody be used on for immunofluorescence applications?

This antibody has been shown to react with multiple species, including human, mouse, rat, hamster, bovine, and non-human primate samples, making it versatile for immunofluorescence applications across different model organisms (Cell Signaling Technology).

How does this antibody contribute to understanding Src's role in cell motility?

The Src (36D10) Rabbit mAb has been utilized in studies that explore the signaling pathways involved in cell motility, particularly in cancer cells. For instance, it has been referenced in research focusing on the interaction between Src-family kinases and actin assembly, which is crucial for cell migration (Kabrawala et al., 2020).

Cell Signaling Technology

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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal MetastasisCancer ResApril 16, 2026Amal T. Elhaw, Priscilla W. Tang, Ya-Yun Cheng, Shriya Kamlapurkar, Zaineb Javed, Sarah Al-Saad, Sierra R. White, Ahmed Emam Abdelnaby, Hannah Khan, Alex Seok Choi, et al.1:1000), pFAK (Cell Signaling Technology, 3283, RRID:AB_2173659; 1:1000), SRC (Cell Signaling Technology, 2109, RRID:AB_2106059; 1:1000), pSRC (Cell Signaling Technology, 2101, RRID:AB_331697; 1:1000), GAPDH (Santa Cruz

(2) Src-mediated PHB2 phosphorylation disrupts mitochondrial cristae through cardiolipin dissociation in hepatocellular carcinomaRedox BiologyApril 1, 2026Zhehua Shao, Xinnuo Yang, Binben Wang, Xuwen Wang, Duoduo Zhao, Bingchen Liu, Jinliang Nananti-phosphotyrosine (1:1000, Cell Signaling Technology #9411), anti-SRC (1:1000, Cell Signaling Technology #2109), anti-β-actin (1:5000, Sigma-Aldrich A5441), anti-HSP60 (1:1000, Cell Signaling Technology #12165),

(3) Synergistic Anti-Tumor Activity of LRPPRC Inhibition and Dasatinib Through Dual Oxidative Phosphorylation DisruptionPharmaceuticals (Basel)March 12, 2026Jing Chen, Lu Gao, Yuxin Liang, Wei Zhou, Yong Wang, Xiaojia Wang, Xiaohong Fang, Xiying Shaoanti-FYN (17237-1-AP, 1:1000, Proteintech, Chicago, IL, USA), Rabbit monoclonal anti-Src (clone 36D10; 2109, 1:1000, Cell Signaling Technology, Danvers, MA, USA). HRP-conjugated secondary antibodies (BS124446,

(4) PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive TumorigenesisCancer DiscoveryMarch 2, 2026Shuang Tang, Qian Zhou, Johann S. Bergholz, Tao Jiang, Weihua Wang, Renlei Ji, Wendi Huang, Jiachen Wu, Yutong Li, Xiaochun Wan, et al.Pan-p-Tyr (Cell Signaling Technology, cat. #9411, RRID: AB_331228), SRC (Cell Signaling Technology, cat. #2109, RRID: AB_2106059), p-SRCY416 (Cell Signaling Technology, cat. #6943, RRID: AB_10013641), GST (Cell Signaling Technology

(5) Activated protein C drives β-arrestin-2- and c-Src-dependent phosphorylation of Cav1 and modulates Cav1 association with PAR1 and GRK5Journal of Biological ChemistryMarch 1, 2026Huaping Qin, Lennis B. Orduña-Castillo, Olivia Molinar-Inglis, Monica L. Gonzalez Ramirez, Miguel A. Lopez-Ramirez, Carolyne Bardeleben, JoAnn Trejo#3251), anti-βarr2 (Abcam, #ab54790), GAPDH (GeneTex, #GT239), c-Src Y416 (CST, #2101), anti-c-Src (CST, #2109), GRK5 (Santa Cruz, #sc-518005), GRK5 polyclonal antibody (Invitrogen, #PA5-96262) anti-GRK4-6 (Millipore,

(6) Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for AsthmaInflammationFebruary 10, 2026Gunnar Pejler, Aida Paivandy, Fabio Rabelo Melo, Venkata Sita Rama Raju Allam, Agnes Öberg, Quan Wen, Peter Bergsten, Xinran O. ZhaoFAK (1:1000, #3285), Phospho-FAK (Tyr397) (1:1000, #8556), Syntenin-1 (1:1000, #27964), Src (1:1000, #2109), Phospho-Src Family (Tyr416) (1:1000, #2101), Akt (1:1000, #9272), Phospho-Akt (Ser473) (1:2000, #4060),

(7) GH Alters Lymphatic Vessels in Female Mice and STAT5 Phosphorylation in Human Lymphatic Endothelial CellsEndocrinologyJanuary 19, 2026Christopher Walsh, Emily Scott, Elise Wagner, Jerome Walsh, Shashank Reddy, Arshad Ahmad, Reetobrata Basu, Eva Sevick-Muraca, Rich Brody, Uday Sandbhor, et al.2101S, RRID: AB_331697), and total proto-oncogene tyrosine-protein kinase Src (Tyr416) (1:1000, CST Cat# 2109S, RRID: AB_2106059). Blots were incubated overnight with primary antibodies and then with horseradish

(8) N-myristoyltransferase 1-mediated Src Myristoylation Promotes Non-receptor Tyrosine Kinase Pathways in Oral Squamous Cell CarcinomaIn VivoJanuary 2, 2026TAKUMA KOMIYAMA, GORO SUGIYAMA, HANAE KAMOHARA, TAKAHIRO FUJINAGA, WATARU KUMAMARU, MASAFUMI MORIYAMAby incubating 2 μg of rabbit polyclonal anti-Src antibody (1:200) (Cell Signaling Technology; Cat# 2109) with cell lysates overnight at 4˚C in the presence of protein G-Sepharose beads. Immunoprecipitates

(9) Mechanotransduction-driven macrophage polarization via Integrin-SRC-STAT6 pathway in distraction osteogenesisJournal of Orthopaedic TranslationDecember 24, 2025Xu Yan, Haixing Wang, Xuan Lu, Linlong Li, Shanshan Bai, Zitong Li, Han Su, Rongjie Wu, Hui Chen, Yinuo Fan, et al.Cell Signaling Technology, Danvers, USA), p-STAT6 (1:1000, #56554, Cell Signaling Technology, Danvers, USA), SRC (1:1000, #2109, Cell Signaling Technology, Danvers, USA), p-SRC (1:1000, #6943, Cell Signaling Technology, Danvers,

(10) A short intrinsically disordered domain of MCPyV ALTO regulates TBK1 signaling during MCPyV infectionJournal of VirologyDecember 23, 2025Taylor E. Senay, Xiaomei Li, Sneha G. Shirhattikar, Tiana T. Luo, Jianxin Youanti-LgBiT (1:500, Promega N710A), anti-Xpress (1:1,000, Invitrogen 44-0528), and anti-Src (1:1,000, CST 2109S). Secondary antibodies: HRP-conjugated anti-rabbit IgG (1:2,500, CST 7074S) and anti-mouse IgG (1:2,500,

(11) Narciclasine as a potential therapeutic agent to overcome EGFR-TKI resistance in non-small cell lung cancerJ Transl MedDecember 5, 2025Jee Young Sung, Ha-Eun Yoo, Soomi Kim, Suyeun Yu, Sang-Won Park, Ga-Eun Lim, Byung Il Lee, Kyungsil Yoon, Hyo Jung Kim, Sang-Ku Ye, et al.Invitrogen), total STAT3 (#4904, CST), phospho-STAT3 Y705 (#9145, CST), phospho-Src (#6943,CST), total-Src (#2109, CST), phospho-CDK1 Y15 (#4539, CST), phospho-Wee1 (#4910, CST), Myt1 (#4282, CST), p21 (#2947, CST),

(12) FGD3 mediates lytic cell death, enhancing efficacy and immunogenicity of chemotherapy agents in breast cancerJournal of Experimental & Clinical Cancer ResearchNovember 13, 2025Junyao Zhu, Xinyi Dai, Santanu Ghosh, Elaine Wei, Chengjian Mao, Qianjin Jiang, Abigail J. Spaulding, Michael P. Mulligan, Roger Romero, Yoo Jane Han, et al.AB_10693616), phospho-Src (Cell Signaling Technology, 6943, RRID: AB_10013641), Src (Cell Signaling Technology, 2109, RRID: AB_2106059), phospho-eIF2α (Cell Signaling Technology, 3398, RRID: AB_2096481), eIF2α (Cell Signaling Technology

(13) Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growthNeuronNovember 5, 2025Corina Anastasaki, Rui Mu, Chloe M. Kernan, Xuanwei Li, Rasha Barakat, Joshua P. Koleske, Yunqing Gao, Olivia M. Cobb, Xinguo Lu, Charles G. Eberhart, et al.Corp.,Cat# 042-206 S6,Cell Signaling Technologies,Cat# 2217S Src,Cell Signaling Technologies,Cat# 2109S Synaptophysin,Abcam,Cat# ab32127 Synapsin I,Abcam,Cat# ab64581 TRKB,Cell Signaling Technologies,Cat#

(14) Differential Efficacy of Bevacizumab and Erlotinib in Preclinical Models of Renal Medullary Carcinoma and Fumarate Hydratase–Deficient Renal Cell CarcinomaMolecular Cancer TherapeuticsNovember 3, 2025Niki M. Zacharias, Manuel Ozambela, Menuka Karki, Rong He, Pankaj K. Chauhan, Pedro I. Pesquera, Andres E. Hernandez Hernandez Gonzalez, Oscar Ochoa, Alberto Pieretti, Huiqin Chen, et al.(4267, Cell Signaling, RRID:AB_2895042); pSRC (6943, pY416, Cell Signaling, RRID: AB_10013641); SRC (2109, Cell Signaling, RRID:AB_2106059); Signaling); pAKT (4058, pS473, Cell Signaling, RRID:AB_331168); and

(15) The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of Src protein through Lys63-linked polyubiquitination in hepatocellular carcinomaCell Death DisOctober 16, 2025Lihui Zhu, Xiuling Cui, Hongwei Xu, Min Yang, Lihui HanTRIM56 (#ab154862, Abcam, Cambridge, MA, USA), Src (#11097-1-AP, 60315-1-Ig, Proteintech, Chicago, USA; #2109, Cell Signaling Technology, Beverly, USA), p-Src (#6943, Cell Signaling Technology, Beverly, USA), Myc

(16) Development of a cyst-targeted therapy for polycystic kidney disease using an antagonistic dimeric IgA monoclonal antibody against cMETCell Reports MedicineSeptember 16, 2025Margaret F. Schimmel, Bryan C. Bourgeois, Alison K. Spindt, Sage A. Patel, Tiffany Chin, Gavin E. Cornick, Yuqi Liu, Thomas WeimbsAB_390779 p-Src (Tyr 416),Cell Signaling,Cat#6943; RRID: AB_10013641 total Src,Cell Signaling,Cat#2109; RRID: AB_2106059 p-AMPK (Thr 172),Cell Signaling,Cat#2535; RRID: AB_331250 "anti-human IgA, HRP conjugate",Invitrogen,Cat#A18787;

(17) S-nitrosylation of pVHL regulates β 2 adrenergic receptor functionProceedings of the National Academy of SciencesSeptember 16, 2025Zachary W. Grimmett, Hiroki Hayashi, Thomas M. Raffay, Justin Lin, Richard T. Premont, Jonathan S. StamlerBethyl Laboratories Inc.), mouse anti-HSP90 (#610419; BD), rabbit anti-UBE2S (#9630; Cell Signaling), rabbit anti-Src (#2109; Cell Signaling), rabbit anti-c-Cbl (#2747; Cell Signaling), rabbit anti-WSB1 (#11666-1-AP; Proteintech),

(18) Imipramine Inhibits Osteosarcoma Invasion via Src Inactivation and Caspase‐Dependent ApoptosisJournal of Cellular and Molecular MedicineSeptember 1, 2025Yu‐Chang Liu, Chi‐Jung Fang, Li‐Cho Hsu, Fei‐Ting Hsu, Ming‐Hsien Hu,Cell Signalling Technology,Rabbit,1:1000 Src (Tyr416),#6943S,Cell Signalling Technology,Rabbit,1:1000 Src,#2109S,Cell Signalling Technology,Rabbit,1:1000 Slug,#9585S,Cell Signalling Technology,Rabbit,1:1000 Snail‐1,#3879S,Cell Signalling

(19) A recurrent de novo damaging variant in EMP2 causes progressive symmetric erythrokeratodermaProceedings of the National Academy of Sciences of the United States of AmericaAugust 12, 2025Jiang X, Mortlock RD, Pironon N, Zhou J, Hu R, Liu W, Acosta A, Shwayder TA, Hovnanian A, Lifton RP, et al.(Novus Biologicals, NBP1-86847, 1:1000), EGFR (CST, 4267, 1:1000), p-EGFR (Tyr1068, CST, 3777, 1:1000), SRC (CST, 2109, 1:1000), p-Src (Y416, CST, 59548, 1:1000), FAK (CST, 3285, 1:1000), pFAK(Y576/577, Y397) (CST, 3281,

(20) AR+TREM2+ macrophage induced pathogenic immunosuppression promotes prostate cancer progressionNat CommunJuly 29, 2025Qiaohua Wang, Yongjian Wu, Yili Long, Rongna Li, Yu Shi, Yanfen Zheng, Xiaohui Chen, Xiang Li, Yihong Zhou, Xi Huang, et al.mAb (Cell Signalling Technology, 9145 T, 1:1000), Src (36D10) Rabbit mAb (Cell Signalling Technology, 2109, 1:1000), Phospho-Src (Tyr419) Antibody (Affinity Biosciences, AF3162, 1:500), Stat3 (79D7) Rabbit mAb

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Src (36D10) Rabbit mAb

Src (36D10) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Src (36D10) Rabbit mAb from Cell Signaling Technology

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