Cdc42 (11A11) Rabbit mAb 2466S from Cell Signaling Technology

Product Specs
ItemCdc42 (11A11) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2466S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, B
TargetCdc42
HostRabbit
NCBI Gene AliasesCDC42Hs, G25K, TKS
ClonalityMonoclonal
NCBI Full Gene Namecell division cycle 42
Research AreaCytoskeletal Signaling
Clone11A11
Molecular Weight21

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Crosstalk Between FOXN3 and E2F5 Reveals a Novel Tumor Suppressive Pathway in Acute Myeloid Leukemia via MAPK Signaling: Implications for Potential Future Targeted TherapyBlood Lymphat CancerMarch 24, 2026Jinjing Zhang, Qiao Jiang, Tong Liu, Hong Li, Ying Liang, Xianglan Lu, Hui Pang, Shibo Li, Yan Li, Rui Zhangwere as follows: FOXN3 (ab129453, 1:2500, Abcam, UK), E2F5 (A16042, 1:500, ABclonal, China), CDC42 (2466T, 1:1000, Cell Signaling Technology, MA), HDAC1 (34589T, 1:1000, Cell Signaling Technology, MA), PCNA

(2) Context-dependent inhibitory roles of RhoA in 3D invasive cell migration within the extracellular matrixCell ReportsDecember 23, 2025Wakiko Iwata, Yoshihiro Adachi, Junior J. West, Andrew J. Ewald, Yi Zheng, Laura D. Wood, Robert A. Anders, Hiromi Sesaki, Miho Iijima3430, Cell Signaling), RAC1/2/3 (1:1000 dilution, 2465, Cell Signaling), and CDC42 (1:1000 dilution, 2466, Cell Signaling). Immunocomplexes were detected using fluorescently labeled secondary antibodies and

(3) Endothelial cells-derived SEMA3G suppresses glioblastoma stem cells by inducing c-Myc degradationCell death and differentiationDecember 1, 2025Min PX, Feng LL, Zhang YX, Jiang CC, Zhang HZ, Chen Y, Fukunaga K, Liu F, Zhang YJ, Sasaki T, et al.MA, USA), PLXND1 (ab28762, Abcam MA, USA), SOX2 (#23064, Cell Signaling Technology MA, USA), Cdc42 (#2466S, Cell Signaling Technology, MA, USA), Rac1 (05-389, Millipore, MA, USA), RhoA (10749-1-AP, Proteintech,

(4) NLRP3 inflammasome impairs fracture repair in Rheumatoid arthritis through RhoA/Rac1-IL1β axis-mediated suppression of osteoblast differentiationJournal of orthopaedic translationSeptember 1, 2025Miao F, Cai H, Chen Y, Yan Z, Jin R, Dai Y, Li L, Wang H, Xu Y, Sun W.Cat#4376S), P-IκBα (CST, Cat#2859S), RhoA (CST, Cat#2117), Rac1 (Proteinech, Cat#24072-1-AP), CDC42 (CST, Cat#2466S),ROCK2 (CST, Cat#9029), P-ROCK2 (Affinity, Cat#AF3028), NF-κB1 (CST, Cat#12540S), NF-κB2 (CST, Cat#4882S),

(5) VAV2 Drives EGFR-Mediated Rac1 Responses in Prostate CancerMolecular Cancer ResearchAugust 4, 2025Martin J. Baker, Suli Zhang, Daniel Zhang, Joshua Searle, Priti Lal, Cornelis P. Vlaar, Surangani Dharmawardhane, Martín C. Abba, Marcelo G. Kazanietz, Mariana Cooke23A8 (Millipore Cat# 05-389, RRID: AB_309712); anti-Cdc42 clone 11A11 (Cell Signaling Technology Cat# 2466, RRID: AB_2078082), anti-vimentin (Cell Signaling Technology Cat# 3390, RRID: AB_2216128), anti-phospho-ERK

(6) Tunneling nanotube–like structures regulate distant cellular interactions during heart formationScienceMarch 14, 2025Lianjie Miao, Yangyang Lu, Anika Nusrat, Guizhen Fan, Shaohua Zhang, Luqi Zhao, Chia-Ling Wu, Hongyan Guo, Trang Le Nu Huyen, Yi Zheng, et al.Cell Signaling, 4147S), Notch1 (1:1000, Cell Signaling, 4380S), CDC42 (1:1000, Cell Signaling Technology, 2466S), Jag1 (1:500, Santa Cruz Biotechnology, sc390177), Jag2 (1:1000, Cell signaling, 2210), Delta4 (1:1000,

(7) Noncanonical Wnt/Ror2 Signaling Regulates Basal Cell Fidelity and Branching Morphogenesis in the Mammary GlandbioRxivFebruary 28, 2025Hongjiang Si, Erika Mendoza Mendoza Mendoza, Madelyn Esquivel, Chad J. Creighton, Jianming Xu, Kevin Roarty(1:1000; #2117; Cell Signaling Technology [CST], Danvers, MA), ROCK1 (1:1000; #4035; CST), Cdc42 (1:1000; #2466; CST), Rac1/2/3 (1:1000; #2465; CST), YAP/TAZ (1:1000; #8418; CST), phosphorylated YAP (p-YAP, 1:1000;

(8) Spatial covariance reveals isothiocyanate natural products adjust redox stress to restore function in alpha-1-antitrypsin deficiencyCell Reports MedicineJanuary 21, 2025Shuhong Sun, Chao Wang, Junyan Hu, Pei Zhao, Xi Wang, William E. BalchBiotech (No.HM2289). The GAPDH antibody was purchased from Abcam (No. ab8245). PDIA1 (P4HB) antibody (No. 2466) and PDIA3(Erp57) antibody (No. 1410582) were purchased from Cell Signaling Technology. PDIA4(Erp72)

(9) AAMP and MTSS1 Are Novel Negative Regulators of Endothelial Barrier Function Identified in a Proteomics ScreenCellsSeptember 25, 2024Podieh F, Overboom MC, Knol JC, Piersma SR, Goeij-de Haas R, Pham TV, Jimenez CR, Hordijk PL.Laboratories, Franklin Lakes, NJ, USA), anti-RhoA (#2117, Cell Signaling Technology), anti-Cdc42 (#2466, Cell Signaling Technology), anti-pMLC (#3671, Cell Signaling Technology), anti-myc (#2276, Cell Signaling Technology

(10) Pharmacological manipulation of TRPC5 by kaempferol attenuates metastasis of gastrointestinal cancer via inhibiting calcium involved in the formation of filopodiaInternational Journal of Biological SciencesSeptember 16, 2024Suyun Yu, Rui Deng, Wei Wang, Defang Zou, Liang He, Zhonghong Wei, Yanhong Pan, Xiaoman Li, Yuanyuan Wu, Aiyun Wang, et al.(Cell Signaling Technology, 4058), mTOR (SAB, 21214), PI3K (Proteintech, 21890-1-AP), CDC42 (Cell Signaling Technology, 2466), RhoA (Cell Signaling Technology, 2117), Rac1/2/3 (Cell Signaling Technology, 2465), p-myosin light

(11) A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire DiversityJournal of Clinical ImmunologyNovember 1, 2023Kristian Assing, Sofie E. Jørgensen, Katrine S. Sandgaard, Kerstin De Keukeleere, Marie B.-Hansen, Mikkel S. Petersen, Ulla B. Hartling, Thanis M. K.-de Vaal, Christian Nielsen, Marianne A. Jakobsen, et al.phospho (Y694) (BD) 1:1000, mouse anti-GAPDH (sc-47724, Santa Cruz Biotechnology), rabbit anti-CDC42 (2466, Cell signaling Technology) 1:1000, mouse anti-FLAG (F3165, Sigma-Aldrich) 1:1000, rabbit anti-PAK1

(12) Stress-mediated dysregulation of the Rap1 small GTPase impairs hippocampal structure and functioniScienceSeptember 15, 2023Bjornson KJ, Vanderplow AM, Yang Y, Anderson DR, Kermath BA, Cahill ME.PIMA515739; 1:5000 dilution), Rac1 (Cytokeleton, Cat# ARC03; 1:1000 dilution), Cdc42 (Cell Signaling, Cat# 2466: 1:1000 dilution), Rap1 (Cell Signaling, Cat# 2326; 1:1000 dilution), and Ras (detects K-Ras, H-Ras,

(13) The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancerMolecular MedicineJune 14, 2023Grace Velez Crespo, Jescelica Ortiz, Eliud Hernández O’Farrill, Cornelis P. Vlaar, Mikhail Inyushin, Yuriy Kucheryavykh, Lilia KucheryavykhUSA). Total lysates were subjected to western blot analysis and probed with Cdc42 and Rho antibodies (#2466, #2117, Cell Signalling, Denver, MA, USA). Analysis of Rac inhibitors mechanism of action Lysates

(14) Small GTPase Cdc42, WASP, and scaffold proteins for higher-order assembly of the F-BAR domain proteinScience advancesApril 28, 2023Wan Mohamad Noor WNI, Nguyen NTH, Cheong TH, Chek MF, Hakoshima T, Inaba T, Hanawa-Suetsugu K, Nishimura T, Suetsugu S.Cell Signaling Technology), mouse anti-WASP (#48606, Cell Signaling Technology), or rabbit anti-Cdc42 (#2466, Cell Signaling Technology)] at a 1:100 dilution for 30 min, as described in the legend to Fig. 5. Unbound

(15) PKCε inhibition prevents ischemia‑induced dendritic spine impairment in cultured primary neuronsExperimental and Therapeutic MedicineFebruary 16, 2023Chenjie Ge, Xuefeng Wang, Yunhong Wang, Lilei Lei, Guohua Song, Mincai Qian, Shiliang Wang1:2,000; Cell Signaling Technology, Inc.); rabbit anti-total-cell division cycle 42 (CDC42; cat. no. 2466; 1:1,000; Cell Signaling Technology, Inc.), rabbit anti-β Tubulin (cat. no. 2416; 1:5,000, Cell Signaling Technology

(16) Changes and related factors of blood CCN1 levels in diabetic patientsFrontiers in endocrinologyJanuary 1, 2023Xiang ZY, Chen SL, Qin XR, Lin SL, Xu Y, Lu LN, Zou HD.nitrocellulose membranes. The analysis was performed with anti-CCN1 (ab228592, Abcam, UK), anti-CDC42 (2466T, Cell Signaling Technology, USA), anti-Claudin5 (4C3C2, Invitrogen, USA), anti-COX6c (ab150422, Abcam,

(17) ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42Journal of Experimental & Clinical Cancer ResearchDecember 1, 2022Xin Zhang et al.(phospho S204) (ab79503) and anti-PAK1 (ab131522) antibodies (Abcam, Cambridge, MA, USA); anti-Cdc42 (CST#2466S), anti-N-cadherin (CST#13116S), and anti-Connexin-43 (Cx43) (CST#3512S) antibodies (Cell Signaling technology,

(18) Cycloartocarpin Inhibits Migration through the Suppression of Epithelial-to-Mesenchymal Transition and FAK/AKT Signaling in Non-Small-Cell Lung Cancer CellsMoleculesNovember 22, 2022Sucharat Tungsukruthai, Boonchoo Sritularak, Pithi Chanvorachote(#13116), Snail (#3879), Slug (#9585), FAK (#3285), p-FAK (#3283), AKT (#9272), p-AKT (#4060), Cdc42 (#2466), and GAPDH (#2118), as well as peroxidase-conjugated secondary antibodies were obtained from Cell Signaling Technology

(19) Synthetic Retinoid Kills Drug-Resistant Cancer Stem Cells via Inducing RARγ-Translocation-Mediated Tension Reduction and Chromatin DecondensationAdvanced science (Weinheim, Baden-Wurttemberg, Germany)November 1, 2022Zhang Y, Dong Q, An Q, Zhang C, Mohagheghian E, Niu B, Qi F, Wei F, Chen S, Chen X, et al.1:1000, ab124701), RAR gamma (Abcam, 1:1000, ab191368), p‐MLC2 (CST, 1:1000, #3675), Cdc42 (CST, 1:1000, #2466), gamma H2AX (Abcam, 1:1000, ab 26350), SUV39h1 (CST, 1:1000, #8729), glyceraldehyde‐3‐phosphate dehydrogenase

(20) EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulationNature cell biologyAugust 1, 2022Guo G, Gong K, Beckley N, Zhang Y, Yang X, Chkheidze R, Hatanpaa KJ, Garzon-Muvdi T, Koduru P, Nayab A, et al.p65 (8242), pp65 (3033), pShc (2431), Sp1 (9389), pSTAT1 (9167), STAT3 (12640), pSTAT3 (9145), Cdc42 (2466), RhoA (2117), FAK (71433), pFAK (8556), HA-Tag (2367) and Myc-Tag (2276) antibodies were from Cell Signaling Technology

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Cdc42 (11A11) Rabbit mAb

Cdc42 (11A11) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Cdc42 (11A11) Rabbit mAb from Cell Signaling Technology

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