GCN2 Antibody from Cell Signaling Technology

Yes, the GCN2 antibody has been utilized in studies investigating the integrated stress response, particularly in relation to eIF2α phosphorylation and its role in cellular stress responses. For instance, it has been shown to be involved in the phosphorylation of eIF2α during stress conditions, which is critical for maintaining cellular homeostasis and regulating translation under stress (Pathak et al., 2019; Urano et al., 2022).

The GCN2 antibody has been cited in research focusing on cancer, particularly in studies examining how GCN2 mediates cellular responses to amino acid deprivation and its implications for cancer cell survival. For example, it has been shown that GCN2 activation can influence AKT signaling pathways in non-small cell lung cancer cells under amino acid deprivation (Jin et al., 2021).

The GCN2 antibody has been shown to work effectively in Western blotting and immunoprecipitation applications. It has been used to analyze protein levels and interactions in various studies, including those investigating the effects of stressors on protein synthesis and cellular responses (Nofal et al., 2022; Wang et al., 2018).

Yes, the GCN2 antibody is reactive with multiple species, including humans, non-human primates, mice, and rats, making it suitable for comparative studies across different biological models (Cell Signaling Technology).