Rictor (53A2) Rabbit mAb 2114S from Cell Signaling Technology

Product Specs
ItemRictor (53A2) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2114S
Quantity100 µl
ApplicationsW, W-S
ReactivityH, M, R, Mk
TargetRictor
HostRabbit
NCBI Gene AliasesAVO3, PIA, hAVO3
ClonalityMonoclonal
NCBI Full Gene NameRPTOR independent companion of MTOR complex 2
Research AreaPI3K / Akt Signaling
IsotypeIgG
Clone53A2
Molecular Weight200

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Cell Signaling Technology

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Deciphering Multitarget Mechanisms of Cardiac Glycosides in Acute Myeloid Leukemia Using a Network Pharmacology and Molecular DockingDrug Design, Development and TherapyFebruary 7, 2026Parinya Samart, Jirarat Poohadsuan, Supasorn Chanthateyanonth, Surapol Issaragrisil, Sudjit Luanpitpongantibodies overnight at 4 °C: phospho-mTOR (Ser2448) (#5536), mTOR (#2983), Raptor (#2280), Rictor (#2114), G-β-L (#3274), COX-2 (#12282), and c-Myc (#5605) (Cell Signaling Technology). After washing, membranes

(2) Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasisbioRxivJanuary 15, 2026Alicia R. Lane, Nadia Gonzalez, Avanti Gokhale, Stephanie A. Zlatic, Brooke M. Allen, Noah E. Scher, Anne M. Roberts, Duc M. Duong, Blaine R. Roberts, Alysia D. Vrailas-Mortimer, et al.,Cell Signaling 5683,AB_10841299 Raptor,1:1000,Cell Signaling 2280,AB_2737590 Rictor,1:1000,Cell Signaling 2114,AB_561245 S6K P70,1:1000,Cell Signaling 9202,AB_2179963 S6K pThr389,1:1000,Cell Signaling 9234,AB_331676 SDHA,1:1000,11998,AB_2269803 Steap3,1:1000,ProteinTech

(3) Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosisCellDecember 11, 2025Yaqiu Wang, Jianlin Lu, Alexandre F. Carisey, Sangappa B. Chadchan, Ha Won Lee, R.K. Subbarao Malireddi, Bhesh Raj Sharma, Nagakannan Pandian, Rebecca E. Tweedell, Gustavo Palacios, et al.phospho-P38 (Thr180/Tyr185, 9211, CST, 1:1000), P38 (9212, CST, 1:1000), RAPTOR (2280, CST, 1:1000), RICTOR (2114S, CST, 1:1000) and β-actin (66009–1-IG, Proteintech, 1:3000). The next day, the membranes were incubated

(4) Kynurenic Acid Protects Against Myocardial Ischemia/Reperfusion Injury by Activating GPR35 Receptors and Preserving Mitochondrial Structure and FunctionBiomoleculesOctober 21, 2025Dóra Nógrádi-Halmi, Barbara Erdélyi-Furka, Dóra Csóré, Éva Plechl, Nóra Igaz, László Juhász, Marietta Zita Poles, Bernát Nógrádi, Roland Patai, Tamás Ferenc Polgár, et al.°C, ON" Cleaved caspase-3,"CST, Cat#9664 (RRID: AB_2070042)","1:750, 4 °C, ON" α-tubulin,"CST, Cat#2114 (RRID: AB_2210548)","1:2000, 4 °C, ON" Primary antibodies used for Western blotting. MFN2: mitofusin-2;

(5) Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entryNatureOctober 2, 2025Debasish Paul, Derek L. Bolhuis, Hualong Yan, Sudipto Das, Xia Xu, Christina C. Abbate, Lisa M. M. Jenkins, Michael J. Emanuele, Thorkell Andresson, Jing Huang, et al.(Abcam, ab155564, 1:1,000), β-actin (Abcam, ab6276, 1:2,000), RPTOR (CST, 2280, 1:1,000), RICTOR (CST, 2114, 1:1,000), mLST8 (CST, 3274, 1:1,000), ubiquitin (Santa Cruz, sc-8017, 1:800), TSC1 (CST, 6935, 1:1,000),

(6) Stable Cas9 expression regulates cell growth by facilitating mTORC2 activationNucleic Acids ResearchSeptember 29, 2025Le Yu, Yi Jin, Jianfeng Chen, Zhichuan Zhu, Siyuan Su, Emily M Wilkerson, Joanna Gongora, Erica W Cloer, Michael B Major, Pengda Liu,Cell Signaling Technology,cat#9205 Anti-mTOR antibody,Cell Signaling Technology,cat#2972 Anti-Rictor antibody,Cell Signaling Technology,cat#2114 Anti-Sin1 antibody,Cell Signaling Technology,cat#12860 Anti-Akt1 antibody,Cell Signaling Technology,cat#2938 Anti-Akt

(7) Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infectionsImmunitySeptember 9, 2025Marco Di Gioia, Valentina Poli, Piao J. Tan, Roberto Spreafico, Anne Chu, Alex G. Cuenca, Zhongyang Wu, Mehdi Benamar, Laura Pandolfi, Federica Meloni, et al.,Cell Signaling Technology,Cat# 3806; RRID: AB_10557237 Rictor (53A2) Rabbit mAb,Cell Signaling Technology,Cat# 2114; RRID: AB_2179963 Phospho-PKCalpha/beta II (Thr638/641) Antibody,Cell Signaling Technology,Cat# 9375;

(8) Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 AxisAdvanced ScienceSeptember 1, 2025Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, et al.The incubation was performed at 4 °C overnight with the primary antibodies against Rictor (1:1000, #2114, CST), Raptor (1:1000, #2280, CST), Akt (1:2000, #10176‐2‐AP, Proteintech), p‐Akt(Ser473) (1:1000, #66444‐1‐Ig,

(9) Food insecurity impacts neuroblastoma pathogenesis in murine xenograft tumor modelsCommunications BiologyAugust 31, 2025Keyonna Williams, Sahiti Chukkapalli, Biao Hu, Delawrence Sykes, Kimber Converso-Baran, Olivia Tussing, Anjalika Dandamudi, Payton Thayer, Kendal Donnelly, Samantha Kaminsky, et al.anti‐RPTOR (Cell Signaling #2280), anti‐GBL (Cell Signaling #3274) and anti-RICTR (Cell Signaling #2114), anti-GAPDH (Cell Signaling #2118), anti-SMA Santa Cruz Biotechnology #sc-53015, anti-PARP1 (Santa Cruz Biotechnology

(10) Induction of Triple Negative Breast Cancer Cell Death and Chemosensitivity using mTORC2-directed RNAi NanomedicineCancer Research CommunicationsMarch 1, 2025Shrusti S. Patel, Rebecca S. Cook, Justin H. Lo, Fiona K. Cherry, Ella N. Hoogenboezem, Fang Yu, Nora Francini, Nina T. Cassidy, Joshua T. McCune, Eva F. Gbur, et al.purchased from Cell Signaling Technology: Raptor (1:500, cat #2280, RRID: AB_561245), Rictor (1:500, cat #2114, RRID: AB_2179963), mTOR (1:1,000, cat #2983, RRID: AB_2105622), total Akt (1:2,000, cat #4691, RRID:

(11) Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegenerationMolecular Biology of the CellMarch 1, 2025Alicia R. Lane, Noah E. Scher, Shatabdi Bhattacharjee, Stephanie A. Zlatic, Anne M. Roberts, Avanti Gokhale, Kaela S. Singleton, Duc M. Duong, Mike McKenna, William L. Liu, et al.MABE342,AB_2737590 Raptor,1:1000,Cell Signaling 2280,AB_561245 Rictor,1:1000,Cell Signaling Technology 2114,AB_2179963 S6K P70,1:1000,Cell Signaling Technology 9202,AB_331676 S6K pThr389,1:1000,Cell Signaling Technology

(12) Unveiling RACK1: a key regulator of the PI3K/AKT pathway in prostate cancer developmentOncogeneFebruary 18, 2025Cancan Lyu, Prasanna Kuma Vaddi, Said Elshafae, Anirudh Pradeep, Deqin Ma, Songhai Chen2983), mTORS2448 (# 5536), ERK1/2 (# 4696), phospho-ERK1/2T202/Y204 (# 4370), raptor (# 2280), rictor (# 2114), PI3K kinase p110 (# 4249) and p110 (# 3011), and PTEN (# 9559) were obtained from Cell Signaling Technology

(13) Rapamycin administration causes a decrease in muscle contractile function and systemic glucose intolerance concomitant with reduced skeletal muscle Rictor, the mTORC2 component, expression independent of energy intake in young ratsPLOS ONEDecember 5, 2024Satoru Ato, Chieri Oya, Riki Ogasawaracat#sc-133067, Santa Cruz Biotechnology, Dallas, TX), Raptor (1:1000, cat#2280, CST), Rictor (1:1000, cat#2114, CST), p-p70S6K T389 (1:1000, cat#9205, CST), p70S6K (1:1000, cat#2708, CST), p-4EBP1 T37/46 (1:1000,

(14) β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3KNatural Products and BioprospectingDecember 1, 2024Shiyun Nie, Lizhong Chang, Ying Huang, Heyang Zhou, Qianqing Yang, Lingmei Kong, Yan LiRaptor (#2280S), p-Raptor (#2083S), p70S6K1 (#2708S), p-p70S6K1 (#9206S), p-4E-BP1 (#13443S), Rictor (#2114), p-Rictor (#3806S), p-GSK3β (#9336L), p-S6 (#4858S), N-cadherin (#14215S), Slug (#9585S), caspase 3

(15) Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programmingImmunityNovember 1, 2024Dongkyun Kim, Giha Kim, Rongzhen Yu, Juyeun Lee, Sohee Kim, Mia R. Gleason, Kevin Qiu, Elena Montauti, Li Lily Wang, Deyu Fang, et al.4967;RRID:AB_330288 anti-pAKT (S473) (clone D9E),CST,Cat # 4060;RRID:AB_2315049 anti-Rictor (clone 53A2),CST,Cat # 2114;RRID:AB_2179963 anti-pAKT (T308) (clone C31E5E),CST,Cat # 2965;RRID:AB_2255933 anti-c-Myc (D84C12),CST,Cat

(16) mTORC1 and mTORC2 Co-Protect against Cadmium-Induced Renal Tubular Epithelial Cell Apoptosis and Acute Kidney Injury by Regulating Protein Kinase BJournal of Agricultural and Food ChemistrySeptember 11, 2024Jiaqiao Zhu, Zhonggui Gong, Xueru Wang, Kanglei Zhang, Yonggang Ma, Hui Zou, Ruilong Song, Hongyan Zhao, Zongping Liu, Wenxuan Dong(#2971), p-mTOR (Ser2481) (#2974), mTOR (#2972), p-AKT (Thr308) (#13038), p-AKT (Thr473) (#4060), Rictor (#2114), SQSTM1/p62 (#P0067), LC3B (#L7543), Cleaved-Caspase (#9661), Cleaved-PARP (#9545), Histone H3 (#4499)

(17) mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancerNature cell biologySeptember 1, 2024Lv G, Wang Q, Lin L, Ye Q, Li X, Zhou Q, Kong X, Deng H, You F, Chen H, et al.E4T9Q, 1:1,000 dilution), anti-mTOR (CST, no. 2983, 7C10, 1:1,000 dilution), anti-RICTOR (CST, no. 2114, 53A2, 1:1,000 dilution), anti-RAPTOR (CST, no. 48648, E6O3A, 1:1,000 dilution), anti-SIN1 (CST, no.

(18) Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic painBrain : a journal of neurologyAugust 21, 2024Wong C, Rodriguez-Hernandez LD, Lister KC, Gu N, Cai W, Hooshmandi M, Fan J, Brown N, Nguyen V, Ribeiro-da-Silva A, et al.ChemiDoc Imaging System (Bio-Rad). Antibodies Primary antibodies for western blotting were Rictor (Cat. No. 2114), p-Akt (Ser473; Cat. No. 4060), t-Akt (Cat. No. 4691) and GAPDH (Cat. No. 2118) raised in rabbit (Cell Signalling

(19) Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemiaScience advancesAugust 2, 2024Sakthivel D, Brown-Suedel AN, Lopez KE, Salgar S, Coutinho LE, Keane F, Huang S, Sherry KM, Charendoff CI, Dunne KP, et al.anti–phospho-PTEN (9551, Cell Signaling Technology), anti–β-catenin (8814; Cell Signaling Technology), anti-Rictor (2114; Cell Signaling Technology), anti–phospho-Rictor (Thr1135) (3806; Cell Signaling Technology), anti-MDM2

(20) Serotonin Influences Insulin Secretion in Rat Insulinoma INS-1E CellsInternational Journal of Molecular SciencesJune 21, 2024Yeong-Min Yoo, Seong Soo Joo(#2869), p-mTOR (Ser2448) (#2971), p-mTOR (Ser 2481) (#2974), mTOR (#2983), Raptor (#2280), Rictor (#2114), p-Akt (Thr 308) (#9275), p-Akt (Ser 473) (#9271), p-eIF2α (#3597), eIF2α (#5324), IRE1α (#3294), GRP78/BiP

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Rictor (53A2) Rabbit mAb

Rictor (53A2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Rictor (53A2) Rabbit mAb from Cell Signaling Technology

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