CARD11 (1D12) Rabbit mAb 4435S from Cell Signaling Technology

Product Specs
ItemCARD11 (1D12) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number4435S
Quantity100 µl
ApplicationsW
ReactivityH, M
TargetCARD11
HostRabbit
NCBI Gene AliasesBENTA, BIMP3, CARMA1, IMD11, IMD11A, PPBL
ClonalityMonoclonal
NCBI Full Gene Namecaspase recruitment domain family member 11
Research AreaImmunology and Inflammation
IsotypeIgG
Clone1D12
Molecular Weight130

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Mechanistic Insights Into Immune Cell Dysregulation Mediated by Novel Heterozygous Variants in CARD11 and MALT1Journal of Clinical ImmunologyMarch 26, 2026Rui Li, Xiaochen Sun, Wei Bao, Haolan Yu, YuQing Dan, Chunmei Wu, Yan Ma, Hanlin Yin, Wanyi Lin, Liangjing Lu, et al.anti-IκBα (10268-1, Proteintech), Anti-p-IκBα (2859 S, Cell Signaling Technology, CST), Anti-CARD11 (4435, CST) and Anti-MALT1 (sc-466677, Santa Cruz). Protein Expression and Purification Full length human

(2) Enforced CARD11/MALT1 signaling in dendritic cells triggers hemophagocytic lymphohistiocytosisProceedings of the National Academy of SciencesDecember 17, 2024Sophie E. Isay, Larsen Vornholz, Theresa Schnalzger, Tanja Groll, Thomas Magg, Patricia Loll, Gregor Weirich, Katja Steiger, Fabian Hauck, Jürgen RulandSignaling Technology, Sigma or Proteintech: anti-HA-tag (C29F4) (#3724, CST), anti-CARD11 (1D12) (#4435, CST), anti-pIKKα/β (Ser176/Ser180) (#2694, CST), anti-p-IkB (Ser32, 14D4) (#2859, CST), anti-pp65 (Ser536,

(3) The dual HCK/BTK inhibitor KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphomaLeukemiaJuly 1, 2024Lantermans HC, Ma F, Kuil A, van Kesteren S, Yasinoglu S, Yang G, Buhrlage SJ, Wang J, Gray NS, Kersten MJ, et al.#14643), anti-CYLD (total and 70 kDa, E-10 Santa Cruz), anti-CYLD (40 kDa, #8462 CST), anti-CARD11 (CST, #4435) and anti-β-actin (Sigma-Aldrich, A1978). Primary antibodies were detected with anti-mouse-HRP or anti-rabbit-HRP

(4) Gene Body Methylation of the Lymphocyte-Specific Gene CARD11 Results in Its Overexpression and Regulates Cancer mTOR SignalingMolecular Cancer ResearchNovember 1, 2022Michael H. McGuire et al.kit (PerkinElmer). The following antibodies were used: anti-CARD11 (Cell Signaling Technology Cat# 4435, RRID:AB_2070359; Abcam Cat# ab113409, RRID:AB_10861854; 1:1000), anti-phospho S6 (Cell Signaling Technology

(5) Novel eIF4A1 inhibitors with anti-tumor activity in lymphomaMolecular medicine (Cambridge, Mass.)September 4, 2022Kayastha F, Herrington NB, Kapadia B, Roychowdhury A, Nanaji N, Kellogg GE, Gartenhaus RB.Vinculin (Sigma, V9131, 1:10,000), Cdk7 (sc-529, 1:1000) Nrf2 (CST, #12721, 1:1000) and Card11 (CST, #4435, 1:1000). Densitometry analyses were performed using Image Studio (Licor Biosciences) and presented

(6) Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variantsiScienceFebruary 18, 2022Bedsaul JR, Shah N, Hutcherson SM, Pomerantz JL.,Bethyl Laboratories,Cat#A303–579A; RRID:AB_11125535 Rabbit monoclonal anti-CARD11,Cell Signaling Technology,Cat#4435; RRID:AB_2070359; 1D12 Rabbit polyclonal anti-JNK2,Cell Signaling Technology,Cat#4672; RRID:AB_330915 Rabbit

(7) A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cellsCellular and molecular life sciences : CMLSJanuary 31, 2022Yin H, Karayel O, Chao YY, Seeholzer T, Hamp I, Plettenburg O, Gehring T, Zielinski C, Mann M, Krappmann D.ABIN-1 (Cat# 4664, RRID:AB_10547137), A20 (D13H3) (Cat# 5630, RRID:AB_10698880), CARD11 (1D12) (Cat# 4435, RRID:AB_10694496), p-IκBα (Cat# 9246, RRID:AB_2151442), IκBα (L35A5) (Cat# 4814, RRID: AB_390781) (all

(8) Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activationCommunications biologyJuly 22, 2021Dhar P, Basher F, Ji Z, Huang L, Qin S, Wainwright DA, Robinson J, Hagler S, Zhou J, MacKay S, et al.phospho-PKCθ (Thr538) (CST, 9377), PKCθ (CST, 13643), MALT1 (CST, 2494), Bcl10 (CST, 4237), CARD11 (CST, 4435), Fyn (CST, 4023), phospho-NF-κB p65 (Ser536) (CST, 3033), NFκB p65 (CST, 4764), phospho-ERK(1/2) (Thr202/Tyr204)

(9) Identification of microRNAs that promote erlotinib resistance in non-small cell lung cancerBiochemical PharmacologyJuly 1, 2021A.S. Pal, M. Bains, A. Agredo, A.L. Kasinskicells hsa-miR-5693,4.806839,hsa-miR-5693,6.980146 hsa-miR-3618,4.128858,hsa-miR-432-5p,5.680975 hsa-miR-3657,3.53778,hsa-miR-3618,5.201033 hsa-miR-432-5p,3.447473,hsa-miR-4787-5p,3.098385 hsa-miR-4435,3.369496,hsa-miR-3198,2.666229 hsa-miR-588,3.115648,hsa-miR-4435,2.599998 hsa-miR-4701-3p,3.096875,hsa-miR-588,2.331268 hsa-miR-4787-5p,2.550594,hsa-miR-4693-5p,2.305733 hsa-miR-4521,2.406701,hsa-miR-4797-5p,2.231674 hsa-miR-4499,2.176414,hsa-miR-4775,2.208845 hsa-miR-9-5p,2.139334,hsa-miR-4521,2.115477 hsa-miR-4643,2.074379,hsa-miR-4643,2.072277 hsa-miR-4486,1.758585,hsa-miR-4781-3p,1.938728 hsa-miR-548ac,1.743734,hsa-miR-4757-5p,1.797722 hsa-miR-4757-5p,1.71694,hsa-miR-4328,1.77053 hsa-miR-3926,1.614334,hsa-miR-4638-3p,1.730049 hsa-miR-4760-5p,1.552469,hsa-miR-4329,1.706815 hsa-miR-4748,1.508298,hsa-miR-4634,1.588003 hsa-miR-4792,1.494049,hsa-miR-4499,1.475899 hsa-miR-3198,1.474083,hsa-miR-4791,1.467733 hsa-miR-5694,1.472514,hsa-miR-4792,1.452575 hsa-miR-4778-5p,1.463761,hsa-miR-3665,1.405999 hsa-miR-4638-3p,1.358205,hsa-miR-4701-3p,1.387164 hsa-miR-3677-5p,1.339528,hsa-miR-4753-3p,1.364724 hsa-miR-4794,1.313135,hsa-miR-4793-5p,1.352131 hsa-miR-4693-5p,1.313076,hsa-miR-4706,1.338108 hsa-miR-4797-5p,1.298536,hsa-miR-4698,1.306059 hsa-miR-4328,1.276663,hsa-miR-4488,1.281768 hsa-miR-4753-3p,1.207611,hsa-miR-4778-5p,1.251342 hsa-miR-4781-3p,1.206249,hsa-miR-4740-3p,1.224541 hsa-miR-4488,1.182468,hsa-miR-4330,1.168158 hsa-miR-4740-3p,1.181966,hsa-miR-4748,1.116061 hsa-miR-548ab,1.140096,hsa-miR-3677-5p,1.110286 hsa-miR-4793-5p,1.126522,hsa-miR-4794,1.103088 hsa-miR-4634,1.121035,hsa-miR-4705,1.09914 hsa-miR-4705,1.119791,hsa-miR-4760-5p,1.035345 hsa-miR-4791,1.107927,hsa-miR-4728-5p,0.980355 hsa-miR-4706,1.104596,hsa-miR-548ak,0.893768 hsa-miR-4522,1.043842,hsa-miR-3926,0.810352 hsa-miR-4775,1.017418,hsa-miR-5694,0.804238 hsa-miR-548ak,0.971604,hsa-miR-9-5p,0.732981 hsa-miR-4468,0.943862,hsa-miR-548ac,0.313635 hsa-miR-3665,0.934691,hsa-miR-548ab,0.232357 hsa-miR-548aj-3p,0.926283,hsa-miR-4676-3p,0.222049 hsa-miR-4751,0.891378,hsa-miR-4654,0.120642 hsa-miR-4330,0.883232,hsa-miR-4661-3p,0.244 hsa-miR-4654,0.851533,hsa-miR-4741,0.065 hsa-miR-4661-3p,0.844637,hsa-miR-4516,−0.189 hsa-miR-4329,0.841927,hsa-miR-4751,0.040 hsa-miR-4698,0.837794,hsa-miR-204-3p,−0.128 hsa-miR-4799-3p,0.821699,hsa-miR-4690-3p,−0.318 hsa-miR-4728-5p,0.798065,hsa-miR-4486,−0.225 hsa-miR-4534,0.788234,hsa-miR-548ad,−0.360 hsa-miR-548ad,0.7357,hsa-miR-4468,−0.590 hsa-miR-4762-3p,0.661747,hsa-miR-4522,0.797 hsa-miR-4516,0.544357,hsa-miR-4762-3p,−0.248 hsa-miR-4741,0.529365,hsa-miR-3657,−0.908 hsa-miR-204-3p,0.424363,hsa-miR-548aj-3p,−0.128 hsa-miR-4690-3p,0.383958,hsa-miR-4799-3p,−1.572 hsa-miR-4676-3p,0.331065,hsa-miR-4534,−1.743 The

(10) Targeting BCL10 by small peptides for the treatment of B cell lymphomaTheranosticsJanuary 1, 2020Bao W, Sun C, Sun X, He M, Yu H, Yan W, Wen F, Zhang L, Yang C.anti-p-IKKβ (2697S), anti-RelB (10544), anti-α-tubulin (5335), anti-PARP (9532S), and anti-CARMA1 (4435) were from Cell Signaling Technology; anti-β-actin (A1978) was from Sigma; anti-Bcl10 (A1106) was from

(11) Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation PathwayFrontiers in immunologyJanuary 1, 2020Oikawa D, Hatanaka N, Suzuki T, Tokunaga F.(#9542; 1:1,000), P-ZAP70 (#2701; 1:1,000), ZAP70 (#3165; 1:2,000), P-IKKα/β (#2697; 1:1,000), CARMA1 (#4435; 1:1,000), MALT1 (#2494; 1:1,000), BCL10 (#4237; 1:1,000), CYLD (#8462; 1:1,000), OTULIN (#14127; 1:1,000),

(12) The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca²⁺-Dependent MannerCellsNovember 30, 2018Roest G, Hesemans E, Welkenhuyzen K, Luyten T, Engedal N, Bultynck G, Parys JB.(Thermo Fisher Scientific; # MA3-914) recognizing all PMCA isoforms, anti-SERCA2B (Cell Signaling Technology; # 4435), and anti-vinculin (Sigma-Aldrich; # V-9131). 2.3. Sodium Dodecyl Sulfate (SDS) Polyacrylamide Gel Electrophoresis

(13) Multiplicity among solar-type starsAstronomy & AstrophysicsNovember 1, 2018J.-L. Halbwachs, M. Mayor, S. Udry5007 223778 223782 1.10 1.12 1.22 0.82 0.84 1.08 1.25 1.06 0.81 0.93 1.10 0.87 0.80 1.01 1.20 0.88 0.80 1.12 0.82 0.91 1.12 0.85 1.13 1.22 0.71 1.06 1.05 0.97 1.22 0.90 1.17 1.37 1.02 0.99 0.86 1.34 1.04 0.83 0.92 0.82 0.72 1.15 1.19 0.63 1.11 1.13 0.80 0.95 1.00 1.05 0.80 0.89 0.83 1.11 1.26 1.26 0.98 1.08 −55.20 38.25 −25.53 32.24 −45.55 −7.17 8.78 −5.74 −21.56 −64.95 −18.35 11.63 26.64 63.19 64.68 −5.21 −29.68 −30.51 −2.55 −7.33 −18.55 −49.52 −27.05 −40.86 −30.23 −8.48 −41.03 −14.11 −66.81 −32.72 −65.82 −64.67 −18.24 −27.65 −14.63 9.75 −11.22 −29.29 −13.42 −19.55 2.45 −4.44 −7.15 −12.57 −32.64 −1.60 −51.46 −44.19 −18.58 −24.29 3.32 33.77 −25.02 −19.24 −9.04 −3.92 4.54 −29.26 0.09 0.10 0.08 0.11 0.07 0.09 0.64 0.14 0.06 0.11 0.13 0.08 0.09 0.23 0.49 0.80 0.06 0.10 0.06 0.09 0.14 0.08 0.11 0.14 0.13 0.10 0.06 0.09 0.09 0.09 0.06 0.06 0.09 0.09 0.09 0.13 0.10 0.10 0.07 0.07 0.15 0.11 0.10 0.11 0.15 0.12 0.10 0.04 0.07 0.34 0.06 0.10 0.09 0.12 0.45 0.11 0.37 0.12 0.24 0.20 19.30 0.28 0.31 0.17 2.99 0.29 0.20 10.65 0.38 7.14 0.35 0.75 0.85 5.81 0.24 0.32 0.30 0.12 0.44 0.29 0.15 2.27 0.36 0.44 1.19 0.21 0.31 0.15 0.34 0.30 0.27 0.20 0.33 0.21 0.21 0.32 0.21 0.18 11.38 0.33 0.32 0.67 6.17 0.24 0.27 1.78 0.26 0.05 0.23 0.22 0.14 0.44 0.45 0.27 22.54 0.29 0.76 0.58 48.35 0.80 1.05 0.55 3.34 0.73 0.69 23.46 1.01 7.43 1.14 2.08 1.92 6.95 0.81 1.06 0.90 0.41 1.00 0.94 0.44 6.49 1.02 1.42 3.57 0.69 0.94 0.48 1.11 0.91 0.83 0.65 0.99 0.53 0.66 0.94 0.72 0.64 19.42 0.91 0.96 1.76 15.98 0.63 0.83 5.75 0.92 0.10 0.78 0.69 0.46 1.33 1.00 0.75 29.97 0.73 0.836 0.971 0.000 0.764 0.352 0.986 0.000 0.843 0.971 0.000 0.415 0.000 0.202 0.000 0.027 0.000 0.873 0.350 0.777 0.999 0.449 0.583 0.995 0.000 0.397 0.005 0.000 0.920 0.584 0.996 0.179 0.725 0.760 0.957 0.476 0.973 0.933 0.569 0.934 0.982 0.000 0.611 0.516 0.000 0.000 0.941 0.715 0.000 0.633 0.919 0.923 0.898 0.993 0.046 9.999 0.831 0.000 0.874 11 11 47 10 18 12 22 9 20 48 9 18 14 11 3 53 21 10 30 12 10 14 10 99 8 21 29 12 14 12 30 29 13 13 14 9 11 11 16 17 76 10 11 35 25 10 10 25 16 1 23 10 10 14 1 10 7 11 11 11 88 10 18 12 38 9 20 96 9 36 14 11 3 103 21 10 30 12 10 14 10 99 8 21 29 12 14 12 30 29 13 13 14 9 11 11 16 17 131 10 11 35 25 10 10 25 16 1 23 10 10 14 1 10 13 11 2617 2612 7096 2620 5204 3020 5561 2569 3026 2259 2642 4105 4426 5564 3698 5516 5557 3272 7337 3023 3008 3369 3008 7660 1772 5127 5177 2961 3340 2967 6226 6226 2964 3349 3639 2966 3338 3342 2976 2976 7440 2951 4063 7389 1392 2583 2912 2891 4057 0 4435 2888 2886 5135 0 2887 2853 5048 CST CST SB2O CST CST CST SB2 CST CST SB2O CST SB2O CST SB1 CST SB2O7 CST CST CST CST CST CST CST SB1O CST SB1? SB1O CST CST CST CST CST CST CST CST CST CST CST CST CST SB2O CST CST SB1O SB1O CST CST SB1O CST ? CST CST CST CST ? CST SB2O CST + + + + * * * * + + 80.0342 0.0029 4570. 106. 1227.77 3.35 5954. 294. HD

(14) GSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10Scientific reportsJanuary 22, 2018Abd-Ellah A, Voogdt C, Krappmann D, Möller P, Marienfeld RB.were from Santa Cruz Biotechnology (Santa Monica, CA, USA). IκBα (44D4, #9242), CARD11/CARMA1 (1D12, #4435), GSK3β (27C10, #9315), GSK3α (#9338) were obtained from Cell Signaling (Danvers, MA, USA). ImmunoCultTM

(15) c-REL and IκB_NS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-PrecursorsJournal of immunology (Baltimore, Md. : 1950)August 1, 2017Schuster M, Plaza-Sirvent C, Matthies AM, Heise U, Jeron A, Bruder D, Visekruna A, Huehn J, Schmitz I.reported (20). For detection anti–c-REL (sc-71; Santa Cruz Biotechnology), anti-CARMA1/ CARD11 (mAb #4435; Cell Signaling Technology, Danvers, MA), antiIkBa (sc-371; Santa Cruz Biotechnology), anti–phospho-IkBa

(16) Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion RatsFrontiers in molecular neuroscienceJanuary 1, 2017Jiang J, Luo Y, Qin W, Ma H, Li Q, Zhan J, Zhang Y.

(17) Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein ArmusJournal of cell scienceDecember 1, 2016Jaber N, Mohd-Naim N, Wang Z, DeLeon JL, Kim S, Zhong H, Sheshadri N, Dou Z, Edinger AL, Du G, et al.#9367, 4431 Journal of Cell Science RESEARCH ARTICLE RESEARCH ARTICLE Journal of Cell Science (2016) 129, 4424-4435 doi:10.1242/jcs.192260 A shTNC RFP-Armus shVps34 GFP-2xFYVE RFP-Armus Merge GFP-2xFYVE Merge bar=10

(18) TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpointsCell death & diseaseSeptember 29, 2016Guo X, Yin H, Chen Y, Li L, Li J, Liu Q.

(19) The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and AutoimmunityCellAugust 25, 2016Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL, Elliott PR, McHale D, Maher ER, McKenzie ANJ, Komander D.

(20) Neuroprotective and antioxidant activities of bamboo salt soy sauce against H(2)O(2)-induced oxidative stress in rat cortical neuronsExperimental and therapeutic medicineApril 1, 2016Jeong JH, Noh MY, Choi JH, Lee H, Kim SH.

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CARD11 (1D12) Rabbit mAb

CARD11 (1D12) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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CARD11 (1D12) Rabbit mAb from Cell Signaling Technology

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