eIF2alpha Antibody from Cell Signaling Technology

Yes, the eIF2α antibody has been utilized in studies investigating the integrated stress response, particularly in the context of cancer. For instance, research has shown that the HIV protease inhibitor Nelfinavir modulates eIF2α phosphorylation, triggering a specific integrated stress response in liver tissues of treated mice, indicating its relevance in cancer biology (degassar2016).

The eIF2α antibody has been shown to work effectively in Western blotting applications, as evidenced by its use in various studies to monitor eIF2α levels and phosphorylation states in different experimental setups, including those involving stress responses and cancer treatments (degassar2016-1, sanchezm2017).

The eIF2α antibody is reactive with multiple species, including humans, mice, rats, and non-human primates. This broad reactivity makes it suitable for studies involving human samples as well as various animal models (degassar2016).

The eIF2α antibody has been cited in studies focusing on the modulation of protein synthesis and stress responses, particularly in the context of cancer therapies and the integrated stress response. For example, it has been used to assess the effects of pharmacological agents on eIF2α phosphorylation and its downstream effects in cancer cell lines (kar2023, weller2022).