MEK2 (13E3) Rabbit mAb 9147S from Cell Signaling Technology

Product Specs
ItemMEK2 (13E3) Rabbit mAb
CompanyCell Signaling Technology
Price $336.00 Inquire
Catalog Number9147S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, Mk
TargetMEK2
HostRabbit
NCBI Gene AliasesCFC4, MAPKK2, MEK2, MKK2, PRKMK2
ClonalityMonoclonal
NCBI Full Gene Namemitogen-activated protein kinase kinase 2
Research AreaMAP Kinase Signaling
IsotypeIgG
Clone13000
Molecular Weight45

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancerSignal transduction and targeted therapyMarch 9, 2024Zhang J, Zhao K, Zhou W, Kang R, Wei S, Shu Y, Yu C, Ku Y, Mao Y, Luo H, et al.13149-1-AP), pEGFR (#2234, CST), EGFR (CST, #4267), pMEK (CST, #9154), MEK1 (CST, #2352), MEK2 (CST, #9147), BRAF (CST, #9433), pAKT (CST, #4060), AKT (CST, #9272), pERK (CST, #4376), ERK (CST, #9102), p-mTOR

(2) The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanomaMelanoma ResearchSeptember 22, 2023Matthew W. Boudreau, Emily J. Tonogai, Claire P. Schane, Min X. Xi, James H. Fischer, Jayanthi Vijayakumar, Yan Ji, Theodore M. Tarasow, Timothy M. Fan, Paul J. Hergenrother, et al.1:1000), PARP-1 (CST #9542, 1:1000), ɣ-H2AX (CST #2577 1:1000), MEK1 (CST #9124, 1:1000), MEK2 (CST #9147, 1:1000), p-ERK (CST #9101, 1:1000), ERK (CST #9102, 1:1000), p-YAP (CST13008, 1:500), YAP (CST #14074,

(3) Caspase 3-specific cleavage of MEK1 suppresses ERK signaling and sensitizes cells to stress-induced apoptosisFEBS open bioApril 1, 2023Moriizumi H, Kubota Y, Tsuchiya T, Naka R, Takekawa M.F1804), anti‐Myc 71D10 (Cell Signaling Technology, 2278), anti‐MEK2 13E3 (Cell Signaling Technology, 9147), anti‐phospho‐MEK1/2(S218/S222) 41G9 (Cell Signaling Technology, 9154), anti‐β‐actin 6D1 (Fujifilm

(4) Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2Signal transduction and targeted therapyMarch 6, 2023Wang P, Jia X, Lu B, Huang H, Liu J, Liu X, Wu Q, Hu Y, Li P, Wei H, et al.#2696), CRAF (#53745), Phospho-c-Raf (Ser338, #9427), MEK1/2 (#4694), MEK1 (#12671), MEK1 (#2352), MEK2 (#9147), p-MEK1/2 (Ser217/221, #9154), ERK1/2 (#4695), p-ERK1/2 (Thr202/Tyr204, #4370), GST-Tag (#2624), PD-L1

(5) Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironmentNature cancerMarch 1, 2022Falcomatà C, Bärthel S, Widholz SA, Schneeweis C, Montero JJ, Toska A, Mir J, Kaltenbacher T, Heetmeyer J, Swietlik JJ, et al.Santa Cruz Biotechnology), MEK1 rabbit mAb (1:1000, Cat # 9146, Cell Signaling Technology), MEK2 rabbit mAb (1:1000, Cat # 9147, Cell Signaling Technology), p-ERK (1:1000, Cat # 4377, Cell Signaling Technology), ERK (1:1000, Cat

(6) Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genomeCell reportsAugust 31, 2021Parrish PCR, Thomas JD, Gabel AM, Kamlapurkar S, Bradley RK, Berger AH.#NB100–87009, 1:2000), MEK1 (Cell Signaling Technology #2352, 1:1000), MEK2 (Cell Signaling Technology #9147, 1:1000), OXSR1 (alias OSR1, Cell Signaling Technology #3729, 1:1000), STK39 (alias SPAK, Cell Signaling Technology

(7) Cancer Selective Target Degradation by Folate-Caged PROTACsJournal of the American Chemical SocietyMay 19, 2021Liu J, Chen H, Liu Y, Shen Y, Meng F, Kaniskan HÜ, Jin J, Wei W.(A301-985A-M) antibody was purchased from Bethyl Laboratories. Anti-ALK (3633), MEK1 (2352), and MEK2 (9147) antibodies were purchased from Cell Signaling Technologies. FOLR2 (PA5-45768) antibodies were purchased

(8) Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule DegradersJournal of medicinal chemistryDecember 24, 2020Hu J, Wei J, Yim H, Wang L, Xie L, Jin MS, Kabir M, Qin L, Chen X, Liu J, et al.bicinchoninic acid (BCA) protein assay kit. The primary antibodies used were MEK1 (2352, CST), MEK2 (9147, CST), pMEK (9121, CST), ERK (4696, CST), pERK (4370, CST), α-tubulin (T6074, Sigma-Aldrich), IKZF1

(9) A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1Scientific reportsJuly 29, 2019Park SW, Nhieu J, Persaud SD, Miller MC, Xia Y, Lin YW, Lin YL, Kagechika H, Mayo KH, Wei LN.and Flag (F3165) were from Millipore Sigma. Antibodies against Mek1 (#12671), p-Mek1 (#9127), Mek2 (#9147), p-Erk1/2 (#9101), p-cRaf S259 (#9421), and p-cRaf S338 (#9427) were from Cell Signaling. AtRA and

(10) Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK DegradationCell Chemical BiologyAugust 1, 2018Jessie Peh, Matthew W. Boudreau, Hannah M. Smith, Paul J. Hergenrother(Rabbit),Cell Signaling Technology,Product # 9146 MEK2 (Rabbit),Cell Signaling Technology,Product # 9147 p-MEK1/2 (Ser217/Ser221) (Rabbit),Cell Signaling Technology,Product # 9121 p-ERK1/2 (Thr202/Tyr204)

(11) Cancer drug addiction is relayed by an ERK2-dependent phenotype switchNatureOctober 12, 2017Kong X, Kuilman T, Shahrabi A, Boshuizen J, Kemper K, Song JY, Niessen HWM, Rozeman EA, Geukes Foppen MH, Blank CU, et al.(Thr202/Tyr204, 9106), ERK1/2 (9102), pMEK1/2 (Ser217/221, 9154), MEK1/2 (4694), MEK1 (2352), MEK2 (9147), JUNB (3753), pFRA1 (Ser265, 5841), p-cJUN (Ser73, 3270) and cJUN (2315) BCL2 (4223) from Cell Signaling Technology

(12) Mitogen-Activated Protein Kinase Kinase 2, a Novel E2-Interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling PathwayJournal of VirologyNovember 15, 2016Jinghan Wang et al.anti-phosphorylated MEK2 (p-MEK2) (catalog no. 9154S; Cell Signaling Technology) or an anti-MEK2 (catalog no. 9147S; Cell Signaling Technology) monoclonal antibody (MAb). The bound proteins in the agarose were subjected

(13) Deletion of MAP2K2/MEK2: a novel mechanism for a RASopathy?Clinical geneticsFebruary 1, 2014Nowaczyk MJ, Thompson BA, Zeesman S, Moog U, Sanchez-Lara PA, Magoulas PL, Falk RE, Hoover-Fong JE, Batista DA, Amudhavalli SM, et al.2338), P-ERK1/2 (Cell Signaling, 9101), Total MEK1 (Cell Signaling, 2352), Total MEK2 (Cell Signaling, 9147), Total ERK (Cell Signaling, 9102), Sprouty 1 (Zymed, 40–1800), Anti-GAPDH (Ambion, AM4300). Proteins

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MEK2 (13E3) Rabbit mAb

MEK2 (13E3) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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MEK2 (13E3) Rabbit mAb from Cell Signaling Technology

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