TIMP2 (D18B7) Rabbit mAb 5738S from Cell Signaling Technology

Product Specs
ItemTIMP2 (D18B7) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number5738S
Quantity100 µl
ApplicationsW, W-S
ReactivityH, M, Mk
TargetTIMP2
HostRabbit
NCBI Gene AliasesCSC-21K, DDC8
ClonalityMonoclonal
NCBI Full Gene NameTIMP metallopeptidase inhibitor 2
Research AreaAdhesion/ECM
IsotypeIgG
CloneD18B7
Molecular Weight22 kDa

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Brain-rejuvenating factor TIMP2 is associated with brain health and neuroprotective lifestyle in aged subjectsmedRxivJanuary 3, 2026Emily W. Paolillo, Samuele F. Petridis, Ana Catarina Ferreira, Hanxiao Liu, Jeffrey D. Zhu, Rowan Saloner, Anna M. Vandebunte, Claire J. Cadwallader, Coty Chen, Joel H. Kramer, et al.nitrocellulose membranes, and blots were probed with anti-TIMP2 antibody (1:500, Cell Signaling, cat. #5738S) and developed as previously described (6). Plasma TIMP2 band intensities were quantified using FIJI

(2) Immune cell uptake of glycinated nanoparticles conjugated to anti-fibrotic peptides enables their prolonged activity and oral administrationJ Biomed SciDecember 12, 2025Deidree V. N. Somanader-Livera, Chen Wei, Chao Wang, Yifang Li, Dorota Ferens, Ekaterina Salimova, Cordelia Selomulya, Mohammed Akhter Hossain, Chrishan S. Samuel, Amlan Chakraborty(ab38978; 1:1000 dilution; Abcam Antibodies) or rabbit monoclonal (IgG) antibody to detect TIMP-2 (#5738; 1:1000 dilution; Cell Signaling Technology; Danvers, MA, USA). In each case, these membranes were reprobed

(3) Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer ModelsACS Pharmacology & Translational ScienceNovember 14, 2025Alicja Urbaniak, Billie Heflin, Eric R. Siegel, Drew Seale, Megan R. Reed, James S. Nix, Eric U. Yee, Marta Jędrzejczyk, Greta Klejborowska, Natalia Stępczyńska, et al.followed by incubation for 3 h at room temperature with primary antibodies against TIMP2 (cat. no. 5738, Cell Signaling Technology, Danvers, MA, USA, 1:1000 dilution) and GAPDH (cat. no. 2118, Cell Signaling Technology

(4) IL-5 signaling in asthmatic derived fibroblasts exacerbates airway remodeling through ECM dysregulation and apoptosis resistanceRespiratory ResearchNovember 4, 2025Rola Abujabal, Tasneem M. Alanta, Reem Sami Alhamidi, Alaa Muayad Altaie, Lina Sahnoon, Bushra Mdkhana, Bassam Mahboub, Yves Laumonnier, Rifat Hamoudi, Khuloud Bajbouj, et al.Cat No.13667" TIMP-1,"Rabbit Monoclonal, CST, Cat No. 8946" TIMP-2,"Rabbit Monoclonal, CST, Cat No. 5738" Caspase-3,"Rabbit Monoclonal, CST, Cat No. 14220" GAPDH,"Rabbit Monoclonal, CST, Cat No. 2118" Tubulin,"Mouse

(5) A combination of silica and cigarette smoke extract exacerbates lung fibrosis: Unveiling a harmful synergyPLoS OneAugust 22, 2025Fahad Alsohime, Narjes Saheb Sharif-Askari, Nasser Saleh Alharbi, Mohammed Faraj Ayad Alosaimi, Rabih HalwaniMuscle Actin/αSMA (#19245, 1:1000), anti-MMP2 (#40994, 1:1000), anti-MMP1 (#54376, 1:1000), anti-TIMP2 (#5738, 1:1000) and anti-GAPDH (#2118, 1:1000) (Cell Signaling Technologies, Danvers, MA), anti-COL3A1 (ab7778,

(6) Growth Hormone Signaling in Bladder Cancer: Transcriptomic Profiling of Patient Samples and In Vitro Evidence of Therapy Resistance via ABC Transporters and EMT ActivationInternational Journal of Molecular SciencesJuly 23, 2025Emily Davis, Lydia J. Caggiano, Hannah Munholland, Reetobrata Basu, Darlene E. Berryman, John J. Kopchick(SNAI2),"1:10,000",H,ProteinTech,12129-1-AP TWIST1,1:500,H,CST,90445 TWIST1,1:2000,M,ProteinTech,25465-1-AP MMP2,1:1000,H,CST,87809 MMP2,1:1000,M,ProteinTech,10373-2-AP MMP9,1:1000,H,CST,13667 MMP9,1:1000,M,ProteinTech,10375-2-AP MMP14,1:1000,H/M,Invitrogen,MA5-32076 TIMP1,1:1000,M,CST,63363 TIMP1,1:500,H,ProteinTech,16644-1-AP TIMP2,1:1000,H/M,CST,5738 TGF-β,1:500,H/M,CST,3711 ABCB1,1:1000,H/M,ProteinTech,22336-1-AP ABCC1,1:500,H,CST,72202 ABCC1,1:1000,M,Abcam,AB260038 ABCC2,1:500,H,CST,12559 ABCC2,1:1000,M,Invitrogen,PA5-86719 ABCG2,1:2000,H/M,ProteinTech,27286-1-AP GHR,1:1000,H/M,Bioss

(7) UHRF1 phase separation mediates stable inheritance of DNA methylation and promotes the proliferation of prostate cancer cellsCell Commun SignalJune 20, 2025Zhean Li, Yihan Wang, Ziqi Yu, Yujia Luo, Yixiang Zhao, Erfei Xue, Junfeng Zhan, Huimin Lu, Fei SunProteintech, Wuhan, China) at 1:1000 dilution, tissue inhibitor of metalloproteinase 2 (TIMP2) (Catalog #5738, Cell Signaling Technology, Danvers, USA) at 1:1000 dilution, glutathione S-transferase pi-1 (GSTP1)

(8) Characterization of Protein Expression and Signaling Pathway Activation That May Contribute to Differential Biological Functions in Porcine Arterial and Venous Smooth Muscle CellsInternational journal of molecular sciencesMarch 28, 2025Arteaga EC, Wai C, Uriyanghai U, Rudraraju M, Su H, Sudarsanam VA, Haddad SO, Poulton JS, Roy-Chaudhury P, Xi G.anti-paxillin (ab32084) antibodies were purchased from Abcam (Cambridge, UK). The anti-ILK (3862), anti-TIMP-2 (5738), anti-pERK1/2(9101), anti-pJNK (9251), anti-pP38 (9211) and anti-pAKT (Serine 473) (9271) antibodies

(9) Histidine Tag-Specific PEGylation Improves the Circulating Half-Life of TIMP2ACS Applied Bio MaterialsMarch 17, 2025Jack Toor, Wiktoria R. Grabowska, Adam L. Johnson, Jane Jones, William G. Stetler-Stevenson, Hanieh Khalili, David Peeneyat −80 °C for later analysis via immunoblotting using a TIMP2 antibody (Cell Signaling Technology, #5738). Densitometric analysis was performed using ImageJ. Pharmacokinetic Testing Four C57BL/6J mice (two

(10) Fucoxanthin from Laminaria japonica Targeting PANoptosis and Ferroptosis Pathways: Insights into Its Therapeutic Potential Against Ovarian CancerMar DrugsMarch 12, 2025Yaze Wang, Yiru Mao, Hui Liu, Yi Huang, Rong Xufollowing the methods described in a recent work [10]. Primary antibodies against GPX4 (13116), SLC7A11 (5738), GAPDH (4249), and actin (2548) were purchased from Cell Signaling Technology (Danvers, MA, USA). HMOX-1

(11) Protocol to study secretome interactions using extracellular proximity labelingSTAR ProtocolsDecember 20, 2024Joshua A. Rich, Sadeechya Gurung, Sasha Coates-Park, Yueqin Liu, Anshika Govil, William G. Stetler-Stevenson, David Peeney(1:2,000 dilution)",Cell Signaling Technology,13202 "TIMP2 (1:2,000 dilution)",Cell Signaling Technology,5738 ,, "Chemicals, peptides, and recombinant proteins","Chemicals, peptides, and recombinant proteins","Chemicals,

(12) Ethyltoluenes Regulate Inflammatory and Cell Fibrosis Signaling in the Liver Cell ModelToxicsNovember 27, 2024Suryakant Niture, Sashi Gadi, Hieu Hoang, Leslimar Rios-Colon, Wanda Bodnar, Keith E. Levine, Deepak Kumarpurchased from Cell Signaling Technology (Danvers, MA, USA): anti-p21 (Cat #2947s), anti-TIMP2 (Cat #5738s), anti-MMP2 (Cat #13132s), anti-TGFβ (Cat #3711s), and anti-β-tubulin (Cat # 2128S). After incubation

(13) Intramyocardial injection of hypoxia-conditioned extracellular vesicles increases myocardial perfusion in a swine model of chronic coronary diseaseJTCVS OpenAugust 1, 2024Dwight D. Harris, Sharif A. Sabe, Mark Broadwin, Christopher Stone, Cynthia Xu, Meghamsh Kanuparthy, Akshay Malhotra, M. Ruhul Abid, Frank W. Sellke,Cell Signaling,4060 Protein kinase B,Cell Signaling,9272 Tissue inhibitor of metalloproteinases 2,Cell Signaling,5738 Secondary antibodies,, Anti-mouse HRP-linked antibody,Cell Signaling,7076S Anti-rabbit HRP-linked

(14) Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathwayFrontiers in PharmacologyFebruary 26, 2024Qian Meng, Hongwen Zhu, Yuanyuan Li, Xiaotian Peng, Tianming Wang, Hui Huang, Hu Zhou, Yuejia Liu, Sujie Ru, Jiasheng Wu, et al.(151613-1-AP, Proteintech), anti-COL1A1 (NBP1-30054, Novus), anti-α-SMA (ab124964, Abcam), anti-TIMP2 (5738, CST), anti-TGF-β (ab92486, Abcam), anti-GAPDH (G8795, Sigma-Aldrich), anti-PDGFRβ (13449-1-AP, Proteintech),

(15) Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9Matrix biology : journal of the International Society for Matrix BiologyNovember 1, 2023Coates-Park S, Lazaroff C, Gurung S, Rich J, Colladay A, O'Neill M, Butler GS, Overall CM, Stetler-Stevenson WG, Peeney D.cleaved TIMP4 products (Figure S2A/B). We determined that the TIMP2 antibody (Cell Signaling Technology, #5738) also detects TIMP4, so this N-terminal targeting antibody was used to detect aMMP9 cleavage products

(16) PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signalingCell reportsJune 27, 2023Backe SJ, Votra SD, Stokes MP, Sebestyén E, Castelli M, Torielli L, Colombo G, Woodford MR, Mollapour M, Bourboulia D.(Millipore, #05–1050), anti-6x-His (ThermoFisher Scientific, #MA1–21315), anti-TIMP2 (Cell Signaling, #5738 and R&D Systems, MAB971), anti-MMP-2 antibodies (Cell Signaling, #13132 and Millipore, #MAB3308), anti-MMP-9

(17) Changes in the expression of cancer- and metastasis-related genes and proteins after metformin treatment under different metabolic conditions in endometrial cancer cellsHeliyonJune 1, 2023Carsten Lange, Jana Brüggemann, Theresa Thüner, Julia Jauckus, Thomas Strowitzki, Ariane Germeyeragainst the following human proteins: BCL2L11 (2933), CDH1 (3195), MMP9 (3852) PTEN (9559), TIMP2 (5738; all from Cell Signaling, Leiden, Netherlands), CDKN1A (ab109520) and COL1A1 (ab138492; both from Abcam,

(18) Anti-Inflammatory Effects of Adiponectin Receptor Agonist AdipoRon against Intervertebral Disc DegenerationInternational journal of molecular sciencesMay 10, 2023Ohnishi H, Zhang Z, Yurube T, Takeoka Y, Kanda Y, Tsujimoto R, Miyazaki K, Matsuo T, Ryu M, Kumagai N, et al.GeneTex), anti-TNF-α (GTX110520; GeneTex), anti-TIMP-1 (sc-5538; Santa Cruz Biotechnology), anti-TIMP-2 (5738; Cell Signaling Technology, Danvers, MA, USA) and anti-actin (A5441; Sigma-Aldrich)] for 12 h at 4 °C,

(19) The exocyst complex is an essential component of the mammalian constitutive secretory pathwayJournal of Cell BiologyMay 1, 2023Conceição Pereira, Danièle Stalder, Georgina S.F. Anderson, Amber S. Shun-Shion, Jack Houghton, Robin Antrobus, Michael A. Chapman, Daniel J. Fazakerley, David C. Gershlickmouse anti-LAMP1 antibody (H4A3; 1:10,000; ab25630; Abcam), rabbit anti-TIMP2 antibody (D18B7; 1:1,000; 5738; Cell Signaling Technology), rabbit anti-Cystatin C antibody (EPR4413; 1:5,000; ab109508; Abcam), rabbit

(20) Monosodium Glutamate Perturbs Human Trophoblast Invasion and Differentiation through a Reactive Oxygen Species-Mediated Pathway: An In-Vitro AssessmentAntioxidants (Basel, Switzerland)March 3, 2023Mukherjee I, Biswas S, Singh S, Talukdar J, Alqahtani MS, Abbas M, Nag TC, Mridha AR, Gupta S, Sharma JB, et al.Beverly, MA, USA",8946 4.,anti-TIMP-2,Rabbit,1:1000,"Cell Signaling Technology, Beverly, MA, USA",5738 5.,anti-Xbp1s,Rabbit,1:1000,"Cell Signaling Technology, Beverly, MA, USA",40435 6.,anti-BiP,Rabbit,1:1000,"ABclonal

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TIMP2 (D18B7) Rabbit mAb

TIMP2 (D18B7) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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TIMP2 (D18B7) Rabbit mAb from Cell Signaling Technology

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