FosB (5G4) Rabbit mAb 2251S from Cell Signaling Technology

Product Specs
ItemFosB (5G4) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2251S
Quantity100 µl
ApplicationsW, IP, IHC-P, IF-IC, FC-FP, ChIP, C&R
ReactivityH, M, R
TargetFosB
Molecular Weight38 FosB2 48 FosB
HostRabbit
NCBI Gene AliasesAP-1, G0S3, GOS3, GOSB
ClonalityMonoclonal
NCBI Full Gene NameFosB proto-oncogene, AP-1 transcription factor subunit
Clone5G4
Research AreaMAP Kinase Signaling

Questions and Answers

Can this antibody be used for immunohistochemistry in studying skin conditions?

Yes, the FosB (5G4) Rabbit mAb has been utilized in immunohistochemistry to study the expression of FosB in skin samples, as demonstrated in research investigating the molecular mechanisms underlying rosacea, where it was used to assess the localization of STAT1 and other proteins in skin lesions ().

Is this antibody effective for Western blot applications in cancer research?

The FosB (5G4) Rabbit mAb has been shown to work effectively in Western blot applications, as evidenced by its use in studies examining the role of FOSB in glioma, where it was employed to analyze protein expression levels in tumor samples ().

What species can this antibody detect, and is it suitable for use in multiple myeloma studies?

This antibody is reactive with mouse, human, and rat samples. It has been specifically mentioned in studies related to multiple myeloma, where it was used to investigate the role of c-FOS and FOSB in drug resistance mechanisms ().

How has this antibody been utilized in studies related to neurodegenerative diseases?

The FosB (5G4) Rabbit mAb has been employed in research examining the role of FOSB in neurodegenerative conditions, such as Alzheimer's disease, where it was used to assess the expression of FOSB in human induced pluripotent stem cell-derived neurons, highlighting its potential involvement in neuronal function and disease mechanisms ().

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Website: Technical Support

(1) Pericytes are organ-specific regulators of tissue morphogenesisNat CommunMay 12, 2026Seyed Javad Rasouli, Kai Kruse, Rodrigo Diéguez-Hurtado, Parisa Ghanbari, Anusha Aravamudhan, Mara E. Pitulescu, Ralf H. AdamsAF3075), rat anti-Nestin (1:100, Cosmo Bio, BAM-73-100-EX), rabbit anti-FOSB (1:100, Cell Signaling, #2251), rabbit anti-FOS (1:100, Abcam, ab190289), goat anti-CXCL10 (1:100, Biotechne, AF466-SP), mouse anti-Nestin

(2) Study on the analgesic and anti-inflammatory mechanisms of Jingu Zhitong gel in the treatment of knee osteoarthritis through the IL-17, NGF-TrkA, and COX-2/PGE2 pathwaysFront PharmacolApril 17, 2026Lu Li, Yiyao Liang, Jing Dong, Zhenzhen Su, Xinyu Xu, Ziyin Wu, Xinzhuang Zhang, Jifeng Li, Zhenzhong Wang, Wenjun Liu, et al.Affinity), MMP3 Antibody (AF0217, Affinity), GCP2 Antibody (DF13470, Affinity), FosB (5G4) Rabbit mAb (2251, Cell Signaling), TARC Polyclonal Antibody (PA5-34515, Invitrogen), NGF Rabbit pAb (YT3114, Immunoway),

(3) Neuron-specific epigenetic repression of Cdk5 impairs hippocampal-dependent memory in male and female micebioRxivApril 10, 2026Kiara L. Rodríguez-Acevedo, Julia J. Winter, Megan I. Alvarez, Ajinkya Sase, Kyle Czarnecki, Elizabeth A. HellerAntibodies against H3K9/14ac (Millipore #17–615), CREB1 (Millipore #06–863), or FosB (Cell Signaling #2251) were bound to Dynabeads M280 Sheep anti-Rabbit (Thermo Fisher) for 6 hours, followed by overnight incubation

(4) Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosisImmunity & AgeingMarch 29, 2026Renzhi Yang, Ying He, Youkai Pan, Aoyi Geng, Fang Huang, Kai Guo, Hongsheng Zhanganti-PSD95 (1:1000; mouse monoclonal, NeuroMab, 75–028, RRID: AB_2292909), rabbit anti-FOSB (1:1000; CST, 2251S, RRID: AB_2106903), rabbit anti-SYNAPTOPHYSIN (1:1000 for WB; Abclonal, A6344, RRID: AB_2766946), rabbit

(5) Brain-wide induction of ΔFOSB and altered co-activation networks in a rat model for exercise trainingTranslational PsychiatryMarch 26, 2026Marene H. Hardonk, Anna H. Vuuregge, Tom P. Hellings, Leslie Eggels, Wayne I.G.R. Ritsema, Khalid Lamuadni, Unga A. Unmehopa, Gideon F. Meerhoff, Andries Kalsbeek, Paul J. Lucassen, et al.endogenous peroxidase activity. Sections were then washed in TBS and incubated with rabbit anti-FOSB (5G4; #2251, Cell Signaling Technology, RRID: AB_2106903), diluted 1:3000 in supermix (0.25% w/v gelatin, 0.5% v/v

(6) Transcriptional regulation of ventral hippocampus-nucleus accumbens circuit excitability drives cocaine seekingSci AdvMarch 6, 2026Andrew L. Eagle, Chiho Sugimoto, Marie A. Doyle, Daniela Anderson, Seyedeh Leila Mousavi, Megan M. Dykstra, Hayley M. Kuhn, Brooklynn R. Murray, Ryan M. Bastle, Sarah Simmons, et al.Immunoprecipitation was carried out overnight at 4°C using 5 μl of rabbit polyclonal FosB antibody (lot 3; 2251S, Cell Signaling Technology) or 2 μg of rabbit polyclonal IgG isotype (3900S, Cell Signaling Technology).

(7) An MIEN1-based hexamer peptide (LA3IK) inhibits EGF-driven oncogenic signaling in prostate cancer by disrupting EGFR–ERBB2 heterodimerizationScientific ReportsMarch 5, 2026Amit K. Tripathi, Nafees Ahamad, Antariksh Tyagi, Benedicta Quainoo, Adam W. Smith, Pragati Singh, Nirupama Sabnis, Jamboor K. VishwanathaCXCL1/CXCL2 (E5M6D) Rabbit mAb (Cat# 24376S and Cat# 24376 T), JunB (C37F9) Rabbit mAb (Cat# 3753S), FosB (5G4) Rabbit mAb (Cat# 2251S), EGF Receptor (EGFR1) Mouse mAb (Cat# 2256S), HER2/ErbB2 (29D8) Rabbit mAb (Cat# 2165S), IL-8 (E5F5Q)

(8) Ganglioside GM2 induces epithelial-mesenchymal transition (EMT) in cancer cells in a MEK/ERK/Egr1-dependent transcriptional programJournal of Biological ChemistryFebruary 20, 2026Elora Khamrui, Sounak Banerjee, Subha Ray, Aishwarya Ray, Barun Mahata, Troyee Das, Zhumur Ghosh, Kaushik BiswasDusp5 (#PA585961), pERK (#44680G), and total MEK (#MA5-15136) were procured from Invitrogen. FosB (#2251), Ctgf (#86641S), total ERK (#4695S), GAPDH (#97166) pMEK (#9154), N-cadherin (#14215), and Vimentin

(9) Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertensionExp PhysiolJanuary 31, 2026Danuzia Ambrozio‐Marques, Loralie Mei Guay, Alicia A. Koogler, Tim D. Ostrowski, Aline M. Arlindo de Souza, Kathryn Sandberg, Richard Kinkeadat 4°C with anti‐FosB primary antibody (1:500; Cell Signaling Technology, Danvers, MA, USA cat. no. 2251). On the following day, sections were incubated with biotinylated goat anti‐rabbit secondary antibody

(10) Neuro-glial mechanisms underlying sex-based resilience to cardiorespiratory dysfunction in heart failureClin Sci (Lond)January 14, 2026Katherin V. Pereyra, Karla G. Schwarz, Esteban Díaz-Jara, Sinay C. Vicencio, Liena Bravo, Fernando C. Ortiz, Camilo Toledo, Rodrigo Del Rio+ 5% milk. Membranes were incubated overnight at 4°C with anti-FosB (rabbit, 1:1000, Cell Signaling 2251), washed, and incubated with HRP-conjugated anti-rabbit secondary (1:2000, KPL). Bands were visualized

(11) Neuro-glial mechanisms underlying sex-based resilience to cardiorespiratory dysfunction in heart failureClinical ScienceJanuary 14, 2026Katherin V. Pereyra, Karla G. Schwarz, Esteban Díaz-Jara, Sinay C. Vicencio, Liena Bravo, Fernando C. Ortiz, Camilo Toledo, Rodrigo Del Rio+ 5% milk. Membranes were incubated overnight at 4°C with anti-FosB (rabbit, 1:1000, Cell Signaling 2251), washed, and incubated with HRP-conjugated anti-rabbit secondary (1:2000, KPL). Bands were visualized

(12) Single‐Cell Atlas of Aging Human Skin Reveals FOSB ‐Related Transcriptional Programs and Druggable TargetsJournal of Cosmetic DermatologyDecember 1, 2025Youcheng Zhang, Yimin Wang, Dongze Lyu, Yinv Gong, Renpeng Zhouagainst:MT1 (1:50, #PA5‐121779, Invitrogen); Lactoferrin (1:25, #SL‐53498, Santa Cruz); FOSB (1:25, #2251, CST); JAG1 (1:100, #a12733, Abclonal). After washing, HRP‐conjugated secondary antibodies were incubated

(13) Characterization of Drug-Tolerant Persister Cells in Triple-Negative Breast Cancer Identifies a Shared Persistence Program across Treatments and PatientsCancer ResearchNovember 6, 2025Léa Baudre, Grégoire Jouault, Pacôme Prompsy, Melissa Saichi, Sarah Gastineau, Christophe Huret, Laura Sourd, Ahmed Dahmani, Elodie Montaudon, Florent Dingli, et al.(Dilution: 1:500, Cell Signaling, ref. 2250, RRID: AB_2247211), FOSB (Dilution: 1:500, Cell Signaling, ref. 2251, RRID: AB_2106903), JUNB (Dilution : 1:500, Santa Cruz, ref sc-8051, RRID: AB_2130023), JUND (Dilution:

(14) Characterization of Drug-Tolerant Persister Cells in Triple-Negative Breast Cancer Identifies a Shared Persistence Program across Treatments and PatientsCancer ResNovember 6, 2025Léa Baudre, Grégoire Jouault, Pacôme Prompsy, Melissa Saichi, Sarah Gastineau, Christophe Huret, Laura Sourd, Ahmed Dahmani, Elodie Montaudon, Florent Dingli, et al.(Dilution: 1:500, Cell Signaling, ref. 2250, RRID: AB_2247211), FOSB (Dilution: 1:500, Cell Signaling, ref. 2251, RRID: AB_2106903), JUNB (Dilution : 1:500, Santa Cruz, ref sc-8051, RRID: AB_2130023), JUND (Dilution:

(15) Regulation of stress susceptibility by chromatin-binding protein PHF6 in the pituitary intermediate lobeMolecular psychiatryOctober 6, 2025Liu B, Wang J, Wu X, Gan L, Sun J, Wang G, Li Q, Huang J.1:500), rabbit anti-c-Fos antibody (Abcam, AB222699, 1:1000), rabbit anti-FosB antibody (Cell Signaling, 2251 T, 1:1000), rat anti-mCherry antibody (AB_2536611; 1:500), rabbit anti-CRH antibody (Abcam, ab272391,

(16) Neural and molecular investigation into the paraventricular thalamus for chronic restraint stress induced depressive-like behaviorsJournal of advanced researchSeptember 1, 2025He Y, Ren Y, Chen X, Wang Y, Yu H, Cai J, Wang P, Ren Y, Xie P.at 4℃. In detail, c-Fos (1:1000, Novus, NBP2-50057), NPY (1:1000, CST, #11976), FosB (1:800, CST, #2251), CamkIIα (1:500, abcam, ab134041), CamkIIα (1:100, Santa Cruz, sc-13141), NeuN (1:1000, abcam, ab104224),

(17) Striatal cell-type–specific molecular signatures reveal potential therapeutic targets in a model of dystoniaNeurobiology of DiseaseAugust 1, 2025Kaitlyn M. Roman, Ashok R. Dinasarapu, Suraj Cherian, Xueliang Fan, Yuping Donsante, Nivetha Aravind, C. Savio Chan, H.A. Jinnah, Ellen J. Hessincubated with primary antibodies against FOSB (rabbit monoclonal anti-FOSB, Cell Signaling Technology #2251, 1:150), TH (rabbit polyclonal anti-TH, Pel-Freez Biologicals #P40101–0, 1:1000) and β-actin (mouse

(18) Ageing reveals the latent effects of early life stress on respiratory and metabolic function in female rats: Novel insights into the sex‐specific origins of sleep apnoeaExperimental PhysiologyJuly 20, 2025Danuzia Ambrozio‐Marques, Loralie Mei Guay, Alicia A. Koogler, Tim D. Ostrowski, Richard KinkeadTBS. The sections were then incubated overnight at 4°C with the primary antibody for FosB (cat. No. 2251, Cell Signaling Technology, Danvers, MA, USA) at a dilution of 1:2000 in the blocking solution. On the

(19) Ageing reveals the latent effects of early life stress on respiratory and metabolic function in female rats: Novel insights into the sex‐specific origins of sleep apnoeaExp PhysiolJuly 20, 2025Danuzia Ambrozio‐Marques, Loralie Mei Guay, Alicia A. Koogler, Tim D. Ostrowski, Richard KinkeadTBS. The sections were then incubated overnight at 4°C with the primary antibody for FosB (cat. No. 2251, Cell Signaling Technology, Danvers, MA, USA) at a dilution of 1:2000 in the blocking solution. On the

(20) Neuronal endolysosomal alterations induced by Apolipoprotein E4 emerge over time in primary neuronsJournal of Biological ChemistryJuly 15, 2025Emma Nyberg, Sabine C. Konings, Nils Lindblom, Bodil Israelsson, Oxana Klementieva, Isak Martinsson, Gunnar K. Gourasmonoclonal anti-Rab7,Abcam,Cat#ab50533,WB 1: 1000 Rabbit monoclonal FosB (5G4),Cell Signaling,Cat#2251,WB 1:1000 Rat monoclonal anti-CD140a,BD Bioscience,Cat#558774,IF 1:500 Rabbit monoclonal anti-S100β,Abcam,Cat#ab52642,IF

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FosB (5G4) Rabbit mAb

FosB (5G4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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FosB (5G4) Rabbit mAb from Cell Signaling Technology

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