c-Raf Antibody 9422S from Cell Signaling Technology

Product Specs
Itemc-Raf Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number9422S
Quantity100 µl
ApplicationsW, W-S
ReactivityH, M, R, Mk
Targetc-Raf
HostRabbit
NCBI Gene AliasesCMD1NN, CRAF, NS5, Raf-1, c-Raf
NCBI Full Gene NameRaf-1 proto-oncogene, serine/threonine kinase
ClonalityPolyclonal
Research AreaMAP Kinase Signaling
Molecular Weight65 to 75

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Inhibitory Activity of Conferone on FAK Activity and Glutamine Metabolism in Human Colorectal CancerJ Cell Mol MedApril 29, 2026Hien Thi My Ong, Eda Ates, Jaeyong Jung, Jeong Soo Sung, Jae-Chul Pyun, Min-Jung Kang(GLS1, #56750), glutamate–ammonia ligase (GLUL, #80636), glutamate dehydrogenase (GLUD, #12793), c‐raf (#9422), phospho‐c‐raf (#9427), and E‐cadherin (#3195) were purchased from Cell Signalling Technology (Danvers,

(2) GPR35 protects against reperfusion injury in ischemic stroke by binding with the CR2 domain of Raf1Journal of NeuroinflammationFebruary 10, 2026Xiaojun Li, Qi Wang, Qingyu Cheng, Jingyong Zhou, Tingting Qu, Jianling Xu, Yuming Du, Bowen Miao, Yongquan Chen, Weidong Yao, et al.with the indicated primary antibodies: anti-GPR35 (1:1000, Novus, NBP2-24640), anti-Raf1 (1:1000, CST, 9422 S), anti-phospho-ERK/anti-ERK (1:1000, Affinity, AF1015/AF0155), anti-phospho-JNK/anti-JNK (1:1000,

(3) Bromodomain-containing protein 4 knockdown promotes neuronal ferroptosis in a mouse model of subarachnoid hemorrhageNeural Regeneration ResearchFebruary 1, 2026Peng Lu, Fan Zhang, Lei Yang, Yijing He, Xi Kong, Kecheng Guo, Yuke Xie, Huangfan Xie, Bingqing Xie, Yong Jiang, et al.TD6278S, RRID: AB_3096423), rabbit anti-Raf-1 (1:1000, Cell Signaling Technology, Danvers, MA, USA; Cat# 9422T, RRID: AB_390808), rabbit anti-p44/42 MAPK (Erk1/2; 1:3000, Cell Signaling Technology; Cat# 4695T, RRID:

(4) Targeting the protein–protein interaction between the CDC37 cochaperone and client kinases by an allosteric RAF dimer breakerJournal of Biological ChemistryFebruary 1, 2026Alison Yu, Shrhea Banerjee, Sravani Malasani, Bamidele Towolawi, Zhiwei Liu, Zhihong WangSignaling,3700,β-Actin Cell Signaling,4877,HSP90 Cell Signaling,4222,CDC37 Cell Signaling,3285,FAK Cell Signaling,9422,CRAF Cell Signaling,14814,BRAF Cell Signaling,2938,AKT1 Cell Signaling,4337,GSK3α Cell Signaling,2289,PP5 Cell Signaling

(5) HIIT-induced lactate/GPR81 signaling with dual branches converging on ERK1/2 contributes to hippocampal synaptic remodeling and memory improvementFrontiers in Cell and Developmental BiologyJanuary 14, 2026Xuepeng Bian, Qinghui Shang, Lutao Zhu, Jun Liu, Min Wu, Jingjing Li, Shujie Lou(55067-1-AP, Proteintech), PKA (4782S, CST), RAP1 (2399S, CST), PKC (SC-80 Santa), PLC (14247S, CST), Raf1 (9422S, CST), MSK1 (3489S, CST), P90RSK (9355S, CST), ERK (4370T, CST), CREB (9197S, CST), c-Fos (2250S, CST),

(6) Proteomics- and BRET- screens identify SPRY2 as a Ras effector that impacts its membrane organizationiScienceDecember 19, 2025Karolina Pavic, Fiona Elizabeth Hood, Carla Jane Duval, Ganesh babu Manoharan, Christina Laurini, Farid Ahmad Siddiqui, Stephanie Puy Lam Mo, Ian Andrew Prior, Daniel Kwaku Abankwa,Santa Cruz Biotechnology,sc-5284; RRID: AB_626760 Rabbit polyclonal anti-C-Raf,Cell Signaling Technology,9422; RRID: AB_390808 Rabbit monoclonal anti-phospho-C-Raf (Ser338) (56A6),Cell Signaling Technology,9427;

(7) Reversibly unlocking the blood–brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxideActa Pharmaceutica Sinica BDecember 15, 2025Junrong Wu, Guangman Cui, Zhousheng Lin, Wanmei Lin, Yaqing Zhang, Tianhang Zhou, Ping He, Yunjiao Zhang, Guangyu Yao11157-1-AP, IL, USA), p-c-Raf (Cell Signaling Technology 9427, MA, USA), c-Raf (Cell Signaling Technology 9422, MA, USA), p-MEK1/2 (Cell Signaling Technology 9121, MA, USA), MEK1/2 (Cell Signaling Technology 9122,

(8) Membrane potential modulates ERK activity and cell proliferation in human cellseLifeNovember 14, 2025Mari Sasaki, Masanobu Nakahara, Takuya Hashiguchi, Fumihito OnoMEK (4394; Cell Signaling Technology), phospho-MEK (2338; Cell Signaling Technology), total c-Raf (9422; Cell Signaling Technology), phospho-c-Raf (CST9431). Cells were lysed in 50 mM Tris (pH 7.5), 150 mM

(9) SHBs Mitigates Sorafenib‐Induced Apoptosis in Hepatocellular Carcinoma via Activation of RAF1/MEK/ERK Signaling PathwayCancer ScienceSeptember 1, 2025Shuxiang Wu, Yuxiang Hong, Hang Li, Mengxian Lin, Xiaohuang Lin, Xinjian Lin, Xu Lin(4572), eIF4E (9742), p‐eIF4E (9741), AKT, p‐AKT, JNK, p‐JNK, β‐catenin, MEK (9122), p‐MEK (9154), RAF1 (9422), Flag (14793), PTPN1 (5311), and β‐actin (4967) were sourced from Cell Signaling Technology, anti‐SHBs

(10) CSRP2 promotes the glioblastoma mesenchymal phenotype via p130Cas-mediated NF-κB and MAPK pathwaysJ Exp Clin Cancer ResAugust 5, 2025Jiawei He, Liang Zhang, Hao Xu, Chengtian Gao, Wentao Zhao, Bingchang Zhang, Wanhong Han, Wenpeng Zhao, Guowei Tan, Sifang Chen, et al.anti-Olig2 (Cat# 65915 S, 1:1000), rabbit anti-p130Cas (Cat# 13846 S, 1:1000), rabbit anti-Raf-1 (Cat# 9422 S, 1:1000), rabbit anti-p-Raf-1 (Cat# 9421 S, 1:1000), and rabbit anti-Rsk1/2/3 (Cat# 9355 S, 1:1000)

(11) CETSA-MS unveils novel targets engaged by rigosertib to promote anti-tumor activity and inflammatory responsesiScienceJune 20, 2025Petros Kechagioglou, Hajime Yurugi, Camille Dupont, Alexey Chernobrovkin, Rossana Romero, Gregory Harms, Marie Oster, Sandra Ciesek, Rebecca Tweedell, Thirumala-Devi Kanneganti, et al.or RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, CRAF,Cell Signaling Technology,#9422; RRID: AB_390808 pCRAF Ser338,Cell Signaling Technology,#9427; RRID: AB_2067317 MEK1/2,Cell Signaling Technology

(12) Multi-selective RAS(ON) Inhibition Targets Oncogenic RAS Mutations and Overcomes RAS/MAPK-Mediated Resistance to FLT3 and BCL2 Inhibitors in Acute Myeloid LeukemiabioRxivJune 17, 2025Bogdan Popescu, Matthew F. Jones, Madison Piao, Elaine Tran, Andrew Koh, Isabelle Lomeli, Cheryl A.C. Peretz, Natalia Murad, Sydney Abelson, Carolina Morales, et al.(8H10D10, #3700), anti-Erk1/2 (3A7, #9107), antiphoshpo-Erk1/2 (Thr202/Tyr204, #9101), anti-cRAF (#9422), anti-phospho-cRAF (Ser338, 56A6, #9427), anti-MEK (61B12, #2352), anti-phosphoMEK1/2 (Ser217/221,

(13) KSR1 Mediates Small Cell Lung Carcinoma Tumor Initiation and Cisplatin ResistanceMolecular Cancer ResearchJune 3, 2025Deepan Chatterjee, Robert A. Svoboda, Dianna H. Huisman, Benjamin J. Drapkin, Heidi M. Vieira, Chaitra Rao, James W. Askew, Kurt W. Fisher, Robert E. LewisAntibody,AB_2067317,Cell Signaling 9427; 1:500 dilution Anti-c-Raf Antibody,AB_390808,Cell Signaling 9422; 1:1000 dilution Phospho-MEK1/2 (Ser217/221) Antibody,AB_2138017,Cell Signaling 9154; 1:500 dilution Rabbit

(14) Early Growth Response Gene 1 Benefits Autoimmune Disease by Promoting Regulatory T Cell Differentiation as a Regulator of Foxp3Research (Wash D C)April 15, 2025Liu Yang, Xinyan Han, Mengxue Wang, Xiaojuan Zhang, Lupeng Wang, Nuo Xu, Hui Wu, Hailian Shi, Weidong Pan, Fei Huang, et al.standard procedure [35,36]. Primary immunoglobulins against Egr-1 (catalog no. 4523), Raf (catalog no. 9422), p-Mek (catalog no. 9145), p-Erk (catalog no. 4370), Erk (catalog no. 4696), and glyceraldehyde-3-phosphate

(15) The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4ACell reportsJanuary 28, 2025Kochen Rossi J, Nuevo-Tapioles C, O'Keefe RA, Hunkeler M, Schmoker AM, Fissore-O'Leary M, Su W, Ahearn IM, Branco C, Cheong H, et al.Technologies, rabbit monoclonal, E1E9V), and anti-c-RAF (Cell Signaling Technologies, rabbit polyclonal, cat#:9422). Blots were then incubated with IRDye 680LT– or IRDye 800CW–conjugated goat anti-mouse or goat anti-rabbit

(16) Oncogenic non-V600 mutations evade the regulatory machinery of RAF including the Cdc37/Hsp90 chaperone and the 14-3-3 scaffoldTheranosticsJanuary 6, 2025Xiaoyu Wan, Jiajun Yap, Junjun Chen, Yifan Li, Regina Faruk, Nazereth Chor Boon Tan, Yiying Ma, Yiting Lim, Karlina Bte Jubri, Jingyi Hu, et al.in this study include: anti-phospho-ERK1/2 (#4370), anti-phospho-CRAF (Ser259) (#9421), anti-CRAF (#9422), anti-Cdc37 (#4793), and anti-14-3-3 (#8312) anti-ARAF (#4432) (Cell Signaling Technology); anti-HA

(17) Exosomes derived from Umbilical cord mesenchymal stem cell promote hair regrowth in C57BL6 mice through upregulation of the RAS/ERK signaling pathwayJournal of Translational Internal MedicineNovember 8, 2024Yongcui Mao, Pinyan Liu, Jiayun Wei, Ye Xie, Qiuxia Zheng, Xuekai Hu, Jia Yao, Wenbo Mengantibodies, including anti-AR antibody (ab108341, Abcam), anti-phosphorylated c-Raf (Ser338) (56A6) antibody (9422T, Cell Signaling Technology), anti-c Raf antibody (7422T, Cell Signaling Technology), anti-phosphorylated

(18) Unveiling the therapeutic potential: KBU2046 halts triple-negative breast cancer cell migration by constricting TGF-β1 activation in vitroOncology ResearchOctober 16, 2024JINXIA CHEN, SULI DAI, GENG ZHANG, SISI WEI, XUETAO ZHAO, YANG ZHENG, YAOJIE WANG, XIAOHAN WANG, YUNJIANG LIU, LIANMEI ZHAOProteintech Group, Inc. ERK1/2 (cat. no. #4695, SD, USA), p-ERK1/2 (Thr202/Tyr204) (#9101, SD, USA), Raf1 (#9422, SD, USA), and p-Raf1 (Ser338) (#9427, SD, USA) were sourced from Cell Signaling Technology, Inc. MTS

(19) Loss of mitochondrial Ca(2+) response and CaMKII/ERK activation by LRRK2(R1441G) mutation correlate with impaired depolarization-induced mitophagyCell communication and signaling : CCSOctober 10, 2024Chang EE, Liu H, Choi ZY, Malki Y, Zhang SX, Pang SY, Kung MH, Ramsden DB, Ho SL, Ho PW.Phospho-RAF1 (Ser338) (1:1000; Cell Signaling Technology™, 9427 S), RAF1 (1:1000; Cell Signaling Technology™, 9422 S), phospho-Thr73 Rab10 (1:2000; Abcam™, ab230261), Rab10 (1:1000; Cell Signaling Technology™, 8127

(20) Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3LZTR1 E3 Ligase KRAS ComplexACS Chemical BiologySeptember 20, 2024Sophie Piech, Sven Brüschweiler, Josepha Westphalen, Katharina M. Siess, Julio García Murias, Robert Konrat, Johannes W. Bigenzahn, Giulio Superti-Furgaanti-LZTR1 (E-12) (Santa Cruz, SACSC-390166, 1:200 dilution), rabbit monoclonal anti-c-RAF (Cell Signaling, 9422S, 1:1000 dilution), mouse monoclonal anti-FLAG M2 (Sigma, F1804, 1:1000 dilution), and mouse monoclonal

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c-Raf Antibody

c-Raf Antibody from Cell Signaling Technology

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Cell Signaling Technology

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c-Raf Antibody from Cell Signaling Technology

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