Rictor (D16H9) Rabbit mAb (Sepharose ® Bead Conjugate) 5379S from Cell Signaling Technology

Product Specs
ItemRictor (D16H9) Rabbit mAb (Sepharose ® Bead Conjugate)
CompanyCell Signaling Technology
Price $450.00 Inquire
Catalog Number5379S
Quantity400 µl
ApplicationsIP
ReactivityH, M
TargetRictor
Conjugate/TagSepharose ® Bead
HostRabbit
NCBI Full Gene NameRPTOR independent companion of MTOR complex 2
IsotypeIgG
CloneD16H9
Molecular Weight200
NCBI Gene AliasesAVO3, PIA, hAVO3
ClonalityMonoclonal
Research AreaPI3K / Akt Signaling

Questions and Answers

Can this antibody be used to study Rictor in cancer models, particularly in lung cancer?

Yes, the Rictor (D16H9) Rabbit mAb (Sepharose Bead Conjugate) has been utilized in studies investigating mTORC2 signaling pathways in non-small cell lung cancer. For instance, it was employed in immunoprecipitation assays to analyze mTORC2 activity in EGFR TKI-resistant NSCLC cell lines, highlighting its relevance in cancer research ().

Is this antibody effective for detecting Rictor in human tissues?

The Rictor antibody has been shown to detect endogenous levels of total Rictor protein in human samples, making it suitable for applications involving human tissues, as evidenced by its use in various studies including those examining metabolic processes in cancer patients ().

How has this antibody been applied in studies related to insulin signaling?

The Rictor antibody has been used to investigate its role in hepatic insulin signaling pathways. For example, it was involved in studies demonstrating that Rictor is targeted by microRNA-215, which modulates insulin signaling in rat models, indicating its importance in metabolic research ().

What species can this antibody be used with, and how does that impact its versatility in research?

The Rictor (D16H9) Rabbit mAb is reactive with both human and mouse proteins, which enhances its versatility for comparative studies across species in various biological contexts, including cancer and metabolic research. This dual reactivity allows researchers to apply the antibody in a broader range of experimental setups.

Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Pdcd4–Rictor Interaction Suppresses PFKFB3 to inhibit TumorigenesisResearch SquareApril 22, 2026Hsin-Sheng Yang, Yumeng Wang, Yumeng Zokaei, Elham Zokaei, Liang Piecoro, Dava West Piecoro, Yanquan Zhang, Katie S. Zhang, Katie Yang, Xiaoqi Wang, et al.immunoprecipitation. For endogenous immunoprecipitation, 30 μl of Rictor conjugated Sepharose® Beads (Cell signaling, 5379) was incubated with 600 μg of H1299 cell lysates for 1 h at room temperature. After washing with lysis

(2) Thermogenic Adipocytes Promote M2 Macrophage Polarization through CNNM4‐Mediated Mg SecretionAdvanced ScienceDecember 1, 2024Anke Zhang, Junkun Jiang, Chuan Zhang, Houshi Xu, Wenjing Yu, Zhen‐Ning Zhang, Ling Yuan, Zhangming Lu, Yuqing Deng, Haonan Fan, et al.(AB152, Sigma), UCP1 (72298T, Cell Signaling Tech), pSTAT6 (Tyr641) (56554, Cell Signaling Tech), STAT6 (5379, Cell Signaling Tech), pAKT (Ser473) (9271, Cell Signaling Tech), AKT (ab18785, Abcam), anti‐pGSK‐3β

(3) Proteomic analysis identifies deregulated metabolic and oxidative-associated proteins in Italian intrahepatic cholangiocarcinoma patientsBMC CancerDecember 1, 2021Giuliana Cavalloni, Caterina Peraldo-Neia, Annamaria Massa, Carlo Bergamini, Alessandro Trentini, Giovanni De Rosa, Lorenzo Daniele, Fabiola Ciccosanti, Carlo Cervellati, Francesco Leone, et al.homeostasis,3.5,39.2,6 sp|P62805|H4_HUMAN,4118,Histone H4,DNA binding,3.0,17.5,2 sp|P00352|AL1A1_HUMAN,5379,Retinal dehydrogenase 1,Cell signaling,3.0,24,8 Downregulated proteins,Downregulated proteins,Downregulated

(4) TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activationNature communicationsAugust 11, 2020Kim HK, Bhattarai KR, Junjappa RP, Ahn JH, Pagire SH, Yoo HJ, Han J, Lee D, Kim KW, Kim HR, et al.(1:1000, #12860), p70 S6 Kinase (1:100, #9202), RICTOR (1:1000, #2114), RICTOR (Sepharose bead conjugate, #5379), and RAPTOR (1:1000, #2280) (all from Cell Signaling Technology, Danvers, MA, USA); HA (1:2000, 11867423001)

(5) Hepatic miR‑215 target Rictor and modulation of hepatic insulin signalling in ratsMolecular medicine reportsMay 1, 2019Li WD, Xia JR, Lian YS.(p)-AKT (Ser473; 1:1,000; cat. no. 4060, Cell Signaling Technology, Inc.), anti-Rictor (1:1,000; cat. no. 5379, Cell Signaling Technology, Inc.), anti-GSK3β (1:1,000; BM2974, Boster Biological Technology, Pleasanton,

(6) MiR-27b regulates podocyte survival through targeting adenosine receptor 2B in podocytes from non-human primateCell death & diseaseNovember 14, 2018Zheng Z, Hu H, Tong Y, Hu Z, Cao S, Shan C, Lin W, Yin Y, Li Z.

(7) HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2Scientific reportsOctober 26, 2016Wu M, Lin Z, Li X, Xin X, An J, Zheng Q, Yang Y, Lu D.et al. Functional characterization of the TERRA transcriptome at damaged telomeres. Nat Commun. 5, 5379 (2014). 48. Hu, Pu. et al. CUDR promotes liver cancer stem cell growth through upregulating TERT and

(8) Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cellsPloS oneJanuary 1, 2013Fei SJ, Zhang XC, Dong S, Cheng H, Zhang YF, Huang L, Zhou HY, Xie Z, Chen ZH, Wu YL.immunoprecipitates prepared from PC9 cell lysates with Rictor (D16H9) Rabbit mAb (Sepharose Bead Conjugate) (#5379) and Raptor (24C12) Rabbit mAb (Sepharose Bead Conjugate) (#5382) purchased from CST, respectively.

(9) The mechanism of cell membrane ruffling relies on a phospholipase D2 (PLD2), Grb2 and Rac2 associationCellular SignallingAugust 1, 2011Madhu Mahankali, Hong-Juan Peng, Dianne Cox, Julian Gomez-CambroneroCSF-1induced F-actin-rich membrane protrusions and migration in macrophages. J Cell Sci. 2005; 118:5369–5379. [PubMed: 16280551] 9. Di Fulvio M, Frondorf K, Gomez-Cambronero J. Mutation of Y179 on phospholipase

Be the First to Write a Review!

Rictor (D16H9) Rabbit mAb (Sepharose ® Bead Conjugate)

Rictor (D16H9) Rabbit mAb (Sepharose ® Bead Conjugate) from Cell Signaling Technology

Description

Questions and Answers

Cell Signaling Technology

Citations (9)

Reviews

Rictor (D16H9) Rabbit mAb (Sepharose ® Bead Conjugate) from Cell Signaling Technology

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map