Mre11 (31H4) Rabbit mAb 4847S from Cell Signaling Technology

Product Specs
ItemMre11 (31H4) Rabbit mAb
CompanyCell Signaling Technology
Price $336.00 Inquire
Catalog Number4847S
Quantity100 µl
ApplicationsW, IP, IHC-P
ReactivityH
TargetMre11
HostRabbit
NCBI Gene AliasesATLD, HNGS1, MRE11A, MRE11B
ClonalityMonoclonal
NCBI Full Gene NameMRE11 homolog, double strand break repair nuclease
Research AreaCell Cycle / Checkpoint Control
Clone31H4
Molecular Weight81

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) LIPT1 loss confers replication stress and PARP inhibitor sensitivity through PrimPol-mediated ssDNA gapsSci AdvMay 1, 2026Zengfu Shang, Jui-Chung Chiang, Ching-Cheng Hsu, Ciara Newman, Anthony J. Davis, Yuanyuan Zhangbuffer (10% goat serum and 0.1% Triton X-100) for 1 hour at room temperature. Anti-MRE11 (1:200; no. 4847, Cell Signaling Technology, Danvers, MA) and anti-biotin (1:200; 03-3700, Thermo Fisher Scientific,

(2) MiR-142-3p promotes radioresistance by targeting FOXO4 in colorectal cancerBiol DirectApril 3, 2026Xi Wang, Wei-Xi Hua, Ying Liu, Hong-Dan Liincubator. Antibodies against DNA-PKcs (#4602T), Ku80 (#2753S), FOXO4 (#9472S), RAD50 (#3427T), Mre11 (#4847T), NBS1 (#3001T), XRCC1 (#76998T), and DNA Ligase III (#43640T) were purchased from Cell Signaling Technology.

(3) Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP InhibitionCancer ResearchJanuary 9, 2026Joseph L. Sottnik, Madeleine T. Shackleford, Camryn S. Nesiba, Amanda L. Richer, Zoe Fleischmann, Jordan M. Swartz, Carmen E. Rowland, Maggie Musick, Rui Fu, Logan R. Myler, et al.(Ser1981)(D6H9)( Cell Signaling Technology #5883; RRID:AB_10835213); MRE11 (31H4)(Cell Signaling Technology #4847; RRID:AB_10693469); phospho-MRE11 (Ser676)(Cell Signaling Technology #4859; RRID:AB_2145096); p95/NBS1

(4) L-Ascorbic acid preferentially kills KRAS mutant pancreatic cancer cells through DNA damageScientific reportsJuly 2, 2025Jang HL, Kim ST, Hong JY, Jang KT, Heo J, Chon HJ, Park YS, Park JO.poly-ADP-ribose (2947S), phosphor-p53 Ser15 (9286S), p53 (2527S), XRCC1 (2735S), ERCC1 (3886S), Mre11 (4847S), PARP-1 (9532S), cleaved PARP-1 (5625S), cleaved caspase-3 (9661S) (Cell Signaling Technology, Danvers,

(5) Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian CancersAdvanced science (Weinheim, Baden-Wurttemberg, Germany)May 1, 2025Pai Bellare G, Kundu K, Dey P, Philip KT, Chauhan N, Sharma M, Rajput SK, Patro BS.IgG‐HRP conjugated (#7074, RRID: AB_2099233), Mouse IgG‐HRP conjugated (#7076, RRID: AB_330924), MRE11 (#4847, RRID: AB_10693469), Vinculin (#13901, RRID: AB_2728768) were from Cell signalling technology (MA, USA).

(6) Seneca Valley virus infection exploits DNA damage response to facilitate viral replicationJournal of VirologyMarch 18, 2025Jiangwei Song, Zijian Li, Jingjing Yang, Ruiyi Ma, Dan Wang, Rong Quan, Xuexia Wen, Jue Liup-ATR (2853, Ser428), CHK1 (2360), p-CHK1 (2348, Ser345), p-CHK2 (2197, Thr68), CHK2 (6334), Mre11 (4847), Rad50 (3427), p-p95/NBS1 (3001, Ser343), p95/NBS1 (14956), p-IkBα (2859, Ser32), IkBα (9247), p-NF-κB

(7) Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breastbioRxivDecember 8, 2024Joseph L. Sottnik, Madeleine T. Shackleford, Camryn S. Nesiba, Amanda L. Richer, Jordan M. Swartz, Carmen E. Rowland, Maggie Musick, Rui Fu, Patricia L. Opresko, Sanjana Mehrotra, et al.Phospho-ATM (Ser1981)(D6H9)( Cell Signaling Technology #5883); MRE11 (31H4)(Cell Signaling Technology #4847); phosph-MRE11 (Ser676)(Cell Signaling Technology #4859); p95/NBS1 (NBN) (D6J5I)(Cell Signaling Technology

(8) Human papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNAJournal of VirologySeptember 17, 2024Claire D. James, Aya Youssef, Apurva T. Prabhakar, Raymonde Otoa, Jenny D. Roe, Austin Witt, Rachel L. Lewis, Molly L. Bristol, Xu Wang, Kun Zhang, et al.(Abcam, ab9110), WRN 1/1,000 (Cell Signaling Technology, 4666), MRE11 1/500 (Cell Signaling Technology, 4847), and V5-Tag 1/1,000 (Life Technologies, A190-119A). Immunoprecipitation assay Cell lysate was prepared

(9) GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancerNature communicationsMarch 8, 2024Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, et al.Anti-Akt (4685), anti-IRF3 (11904), anti-p-IRF3 (29047), anti-TBK1 (3504), anti-p-TBK1 (5483), anti-MRE11 (4847), anti-Histone H3 (4499) and anti-β-Actin (3700), Anti-Flag-tag (14793), Anti-GAPDH (2118), BRCA2 (10741),

(10) Inhibition of ATM-directed antiviral responses by HIV-1 VifPLoS pathogensSeptember 1, 2023Wong HT, Luperchio AM, Riley S, Salamango DJ.pTRIM28 (1:500, Thermo A300-767A), pMRE11 (1:50, Cell Signaling 4859), MRE11 (1:200, Cell Signaling 4847), pNBS1 (1:200, Cell Signaling 3001), NBS1 (1:200, Novus Biologicals NB100-143), TRIM24 (1:200, Proteintech

(11) An Easy Method to Determine the Effective Conductivity of Carbon Fiber Composites Using a Wall Perturbation ApproachMaterials (Basel)March 17, 2023Moritz Engler, Guido Link, John Jelonnekfor the aluminum reference is measured before and after all prepreg measurements and varies between 4847 and 4872. After generating matching characteristic curves with CST Microwave Studio, the lower and upper

(12) Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathwayCell death and differentiationFebruary 1, 2023Belmonte-Fernández A, Herrero-Ruíz J, Galindo-Moreno M, Limón-Mortés MC, Mora-Santos M, Sáez C, Japón MÁ, Tortolero M, Romero F.(A301-720A, Bethyl laboratories, Montgomery, TX, USA), anti-Flag (F3165, Sigma-Aldrich), anti-MRE11 (#4847, Cell Signaling Technology), anti-NBS1 (#14956, Cell Signaling Technology), anti-RAD50 (NB110-60483,

(13) The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cellsCommunications biologyJanuary 18, 2023Noyes C, Kitajima S, Li F, Suita Y, Miriyala S, Isaac S, Ahsan N, Knelson E, Vajdi A, Tani T, et al.,Cell Signaling Technology,1:1000 (IB) DCLK1,Rabbit,62257,Cell Signaling Technology,1:1000 (IB); 1:200 (IF) MRE11,Rabbit 1,4847,Cell Signaling Technology,1:1000 (IB) ABCG2,Rabbit,42078,Cell Signaling Technology,1:1000 (IB) Phospho-γH2A.X,Rabbit,9718,Cell Signaling Technology

(14) Non-enzymatic function of WRN RECQL helicase regulates removal of topoisomerase-I-DNA covalent complexes and triggers NF-κB signaling in cancerAging cellJune 1, 2022Gupta P, Majumdar AG, Patro BS.Epitomics (Cambridge, UK). Anti‐BrdU (#347580), anti‐PAR from BD Biosciences (San Jose, CA). Anti MRE11 (#4847) from Cell Signaling Technology (Massachusetts, USA). AlexaFlour‐546 and AlexaFlour‐488 tagged secondary

(15) MRNIP condensates promote DNA double-strand break sensing and end resectionNature communicationsMay 12, 2022Wang YL, Zhao WW, Bai SM, Feng LL, Bie SY, Gong L, Wang F, Wei MB, Feng WX, Pang XL, et al.previously described. The primary antibodies used in this paper targeted the following proteins: MRE11 (4847S, CST, 1:1000), Rad50 (3427S, CST, 1:1000), NBS1 (14956S, CST, 1:1000), p-NBS1 (3001S, CST, 1:1000),

(16) LncRNA LINC01134 Contributes to Radioresistance in Hepatocellular Carcinoma by Regulating DNA Damage Response via MAPK Signaling PathwayFrontiers in PharmacologyJanuary 31, 2022Zhiyi Wang, Xinxing Wang, Zhonghou Rong, Longfei Dai, Chengkun Qin, Shikang Wang, Wenmao GengPARP (5625, CST), p-ATM (13050, CST), Rad50 (3427, CST), p-Chk2 (2197, CST), Ku80 (2753, CST), MRE11 (4847, CST), NBS1 (3001, CST), DNA-PKcs (38168, CST), p53 (48818, CST), MAPK1 (4370, CST), ERK (ab32537, Abcam),

(17) Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivoScience advancesSeptember 3, 2021Shahini A, Rajabian N, Choudhury D, Shahini S, Vydiam K, Nguyen T, Kulczyk J, Santarelli T, Ikhapoh I, Zhang Y, et al.4602), Ku80 (Cell Signaling Technology, catalog no. 2180), Mre11 (Cell Signaling Technology, catalog no. 4847), Rad50 (Cell Signaling Technology, catalog no. 3427), X-Ray Repair Cross Complementing 4-like factor

(18) GRB2 enforces homology-directed repair initiation by MRE11Science advancesAugust 1, 2021Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, Tsai CL, Shen Q, Peng G, Leonard PG, et al.PARP (Asp214) (5625S), cleaved caspase-3 (Asp175) (9664S), cleaved caspase-7 (Asp198) (8438S), MRE11 (4847S), RPA70 (2267S), H2AX (7631S), p-H2AX (S139) (20E3) (9718S), RAD50 (3427S), NBS1(14956S), XRCC1 (2735S),

(19) Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney InjuryCancer researchFebruary 1, 2021Hu Y, Yang C, Amorim T, Maqbool M, Lin J, Li C, Fang C, Xue L, Kwart A, Fang H, et al.antibody (Santa Cruz Biotechnology, #sc-56089), rabbit anti-MRE11 monoclonal antibody (Cell Signaling, #4847), rabbit anti-CtIP polyclonal antibody (Bethyl Laboratories, #300-488A), or goat anti-β-actin polyclonal

(20) LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinomaCell death & diseaseJanuary 4, 2021Guo Z, Wang YH, Xu H, Yuan CS, Zhou HH, Huang WH, Wang H, Zhang W.Cat:2853); anti-Rad50 (CST, Cat: 3427); anti-NBS1 (Proteintech, Cat: 55025-1-AP); anti-Mre11 (CST, Cat: 4847); anti-Ku80 (Proteintech, Cat: 16389-1-AP); anti-Ku70 (Proteintech, Cat: 10723-1-AP); anti-Akt (CST,

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Mre11 (31H4) Rabbit mAb

Mre11 (31H4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Mre11 (31H4) Rabbit mAb from Cell Signaling Technology

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