eIF4G Antibody 2498S from Cell Signaling Technology

Product Specs
ItemeIF4G Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number2498S
Quantity100 µl
ApplicationsW, IHC-P, IF-IC, FC-FP
ReactivityH, M, R, Mk
TargeteIF4G
HostRabbit
NCBI Gene AliasesEIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18
NCBI Full Gene Nameeukaryotic translation initiation factor 4 gamma 1
ClonalityPolyclonal
Research AreaTranslational Control
Molecular Weight220

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) The multifaceted role of the viral 2A protease in enterovirus replication and antagonism of host antiviral responsesPLOS PathogensAugust 28, 2025Jelle G. Schipper, Chiara Aloise, Sereina O. Sutter, Marleen Zwaagstra, Arno L.W. van Vliet, Rana Abdelnabi, Bob Ignacio, Kimberly M. Bonger, Dagmar Roelofs, Judith M.A. van den Brand, et al.above. Antibodies. The following antibodies were used for WB analysis: rabbit anti-eIF4GI (1:1000, Cell Signaling, #2498), rabbit anti-DAP5 (1:1000, Invitrogen, #PA-21377), mouse anti-PABP (1:1000, SantaCruz, #sc-32318),

(2) The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infectionJournal of VirologyJuly 22, 2025Ayisha A. Lavender, Oreoluwa Solanke, Hsin-Yao Tang, Hannah E. Peck, Daryll Vanover, Philip J. Santangelo, Margo A. Brintonanti-eIF3A (1:50, Cell Signaling Technology, #3314), rabbit anti-eIF4G (1:50, Cell Signaling Technology, #2498), rabbit anti-V5 (1:200, Cell Signaling Technology, #13202), mouse anti-V5 (1:200, Cell Signaling Technology,

(3) Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy ResponseCancer DiscoveryJuly 3, 2025Alexandra Redding, Guillaume Fonteneau, Stefan Heinrich, Matthias M. Gaida, Elda Grabocka(1:2,000 Bethyl; cat. no. A302-033A, RRID: AB_1576539) and EIF4G (1:500 Cell Signaling Technology; cat. no.2498S, RRID: AB_2096025 or 1:500 Santa Cruz Biotechnology; cat. no.sc-133155, RRID: AB_2095748). Tissue Immunofluorescence All

(4) Stress granule assembly impairs macrophage efferocytosis to aggravate allergic rhinitis in miceNat CommunJuly 1, 2025Ye Zhou, Zixuan Yang, Yuanyuan Wang, Yue Dong, Tianyu Wang, Yunhui Li, Caiquan Liang, Yanfang Liu, Zhixuan Li, Shanrong Liu, et al.ATG CTC GTC AAG AAG ACA G-3’. Reagents Antibodies specific to G3BP1 (45656), LRP1 (64099), eIF4G (2498), horseradish peroxidase coupled secondary antibodies (7074 and 7076) and normal rabbit IgG (2729) were

(5) Genotoxic stress triggers Scd6-dependent regulation of translation to modulate the DNA damage responseEMBO ReportsApril 24, 2025Gayatri Mohanan, Raju Roy, Hélène Malka-Mahieu, Swati Lamba, Lucilla Fabbri, Sidhant Kalia, Anusmita Biswas, Sylvain Martineau, Céline M Labbé, Stéphan Vagner, et al.LSM14A antibody,SantaCruz Biotechnology,sc-398552 Rabbit EIF4G antibody,Cell Signalling Technologies,2498 Mouse EIF4E antibody,Cell Signalling Technologies,9742 Secondary mouse AlexaFluor 594 antibody,ThermoFisher,A32744 RTEL1 antibody

(6) The DEAD-box helicase eIF4A1/2 acts as RNA chaperone during mitotic exit enabling chromatin decondensationNat CommunMarch 11, 2025Ramona Jühlen, Sabine C. Wiesmann, Anja Scheufen, Thilo Stausberg, Isabel Braun, Chantal Strobel, Carmen Llera-Brandt, Sabrina Rappold, Rabia Suluyayla, Marianna Tatarek-Nossol, et al.eIF4B (Cell Signaling, #13088, 1:1000), eIF4E (Cell Signaling, #2067, 1:1000), eIF4G1 (Cell Signaling, #2498, 1:1,000), eIF4H (Cell Signaling, #3469, 1:1000) Mab414 antibody for detection of Nup62 (Biolegend,

(7) Hepatovirus translation requires PDGFA-associated protein 1, an eIF4E-binding protein regulating endoplasmic reticulum stress responsesScience AdvancesNovember 22, 2024Takayoshi Shirasaki, Erik Lenarcic, Ichiro Misumi, Ling Xie, William G. Fusco, Bryan Yonish, Anshuman Das, Hyejeong Kim, Craig E. Cameron, Mélissa Léger-Abraham, et al.Signaling Technology (CST) #4300; anti-Flag, CST #14793; anti-GFP, Santa Cruz sc-9996; anti-eIF4G, CST #2498; anti-eIF4A, CST #2013; anti-eIF4B, CST #3592; anti-eIF4E, CST #9742; anti-eIF1AX, Proteintech #11649-2-AP;

(8) Eukaryotic initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAsNucleic acids researchOctober 28, 2024Quintas A, Harvey RF, Horvilleur E, Garland GD, Schmidt T, Kalmar L, Dezi V, Marini A, Fulton AM, Pöyry TAA, et al.(Abcam, no. ab31217), eIF4A2 (Abcam, no. ab31218), eIF4A3 (Santa Cruz, no. sc-365549), eIF4G (CST, no. 2498), DDX3 (CST, no. 8192), DDX6 (Abcam, no. ab70455), G3BP1 (Abcam, no. ab56574), BCL2 (CST, no. 2872),

(9) eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancerbioRxivSeptember 9, 2024Jacob A. Boyer, Malvika Sharma, Madeline A. Dorso, Nicholas Mai, Corina Amor, Jason M. Reiter, Ram Kannan, Sunyana Gadal, Jianing Xu, Matthew Miele, et al.13258), Estrogen Receptor Alpha C-terminus (CST 8644), Progesterone Receptor (CST 8757), EIF4G (CST 2498), EIF4E (CST 9742), 4EBP1 (CST 9644), Beta Actin (CST 4967), Myc (CST 18583), GATA3 (CST 5852), Cyclin

(10) A novel reporter for helicase activity in translation uncovers DDX3X interactionsRNAAugust 1, 2024Kevin C. Wilkins, Till Schroeder, Sohyun Gu, Jezrael L. Revalde, Stephen N. FloorHRP (Sigma A8592), anti-eIF4A1 antibody (ab31217), anti-eIF4G1 antibody (Cell Signaling Technologies 2498), anti-eIF4E antibody (Cell Signaling Technologies 9742), anti-ribosomal protein S11/RPS11 (ab175213),

(11) mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXSEMBO Molecular MedicineFebruary 19, 2024Vipendra Kumar, Kwan Young Lee, Anirudh Acharya, Matthew S Babik, Catherine A Christian-Hinman, Justin S Rhodes, Nien-Pei Tsaianti-eIF4E (#2067, 1:2500 dilution); rabbit anti-eIF2α (#5324, 1:2500 dilution); rabbit anti-eIF4G (#2498, 1:2500 dilution). Secondary antibodies were from Cell Signaling Technology: anti-mouse HRP (#7076,

(12) A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 ProteaseACS Infectious DiseasesFebruary 9, 2024Kristalle G. Cruz, Maureen Hill Hill Eron, Sparsh Makhaik, Sergey Savinov, Jeanne A. HardyCell Signaling Technologies. ATG16L1 was from lot 2, catalog #8089, eIF4G1 was from lot 4, catalog #2498, SPAG9/JIP4 was from lot 1, catalog #5519, and CycA was from lot 2, catalog #2175. The membrane was

(13) Determinants of DDX3X sensitivity uncovered using a helicase activity in translation reporterbioRxivSeptember 20, 2023Kevin C. Wilkins, Till Schroeder, Sohyun Gu, Jezrael L. Revalde, Stephen N. Floor(Sigma, A8592), anti-eIF4A1 antibody (ab31217), anti-eIF4G1 antibody (Cell signaling technologies #2498), anti-eIF4E antibody (Cell signaling technologies #9742), anti-ribosomal protein S11/RPS11 (ab175213),

(14) Customization of the translational complex regulates mRNA-specific translation to control CNS regenerationNeuronSeptember 20, 2023Schaeffer J, Vilallongue N, Decourt C, Blot B, El Bakdouri N, Plissonnier E, Excoffier B, Paccard A, Diaz JJ, Humbert S, et al.anti-Pabp1 (Cell Signaling Technology, 4992) 1:1000; rabbit anti-eIF4G (Cell Signaling Technology, 2498) 1:1000; rabbit anti-RPS6 (Cell Signaling Technology, 2217) 1:1000; rabbit anti-Gapdh (Cell Signaling Technology

(15) Identification of an alternative triglyceride biosynthesis pathwayNatureSeptember 1, 2023McLelland GL, Lopez-Osias M, Verzijl CRC, Ellenbroek BD, Oliveira RA, Boon NJ, Dekker M, van den Hengel LG, Ali R, Janssen H, et al.1:1,000), anti-CLTC (Thermo Fisher, PA5-17347, WB 1:1,000), anti-EIF4G (Cell Signaling Technology, 2498, WB 1:1,000), anti-FASN (Santa Cruz Biotechnology, sc-55580, WB 1:1,000), anti-HA (Biolegend, 901503,

(16) Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in CancerJournal of medicinal chemistryAugust 10, 2023Cárdenas EL, O'Rourke RL, Menon A, Meagher J, Stuckey J, Garner AL.were used in this study: eIF4E (Cell Signaling Technology, 9742), eIF4G (Cell Signaling Technology, 2498), actin-HRP (Santa Cruz Biotechnology, sc-47778), c-Myc (Cell Signaling Technology, 13987), ODC1 (Novus Biologicals

(17) The ototoxic drug cisplatin localises to stress granules altering their dynamics and compositionJournal of cell scienceJuly 15, 2023Martin JL, Terry SJ, Gale JE, Dawson SJ.ab57654, 1:500), eIF3η (Santa Cruz Biotechnology SC-137214, 1:100), eIF4G (Cell Signaling Technology 2498S, 1:100), DDX3X (Proteintech 11115-1-AP, 1:100), RACK1 (BD Transduction Laboratories 610177, 1:100),

(18) Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress responseThe Journal of biological chemistryJune 1, 2023Oliveira AG, Oliveira LD, Cruz MV, Guimarães DSPSF, Lima TI, Santos-Fávero BC, Luchessi AD, Pauletti BA, Leme AP, Bajgelman MC, et al.(Abcam, #ab110413), PPARD (Thermo Fisher Scientific, #PA1-823A), eIF4G (Cell Signaling Technology, #2498), puromycin (Merck, #MABE343), Vinculin (Cell Signaling Technology, #4650), Lamin A (Santa Cruz Biotechnology,

(19) eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenanceiScienceMay 19, 2023Patil S, Chalkiadaki K, Mergiya TF, Krimbacher K, Amorim IS, Akerkar S, Gkogkas CG, Bramham CR.Rabbit; 1:1000,Cell signalling,"Cat# 9742, RRID: AB_823488" eIF4G; Rabbit; 1:1000,Cell signalling,"Cat# 2498, RRID: AB_2096025" p-MNK1 Thr197/202; Rabbit; 1:500,Cell signalling,"Cat# 2111, RRID: AB_2266303" MNK1;

(20) Spatial patterns of the cap-binding complex eIF4F in human melanoma cellsComputational and structural biotechnology journalJanuary 1, 2023Tang X, Pu Y, Peng H, Li K, Faouzi S, Lu T, Pu D, Cerezo M, Xu J, Li L, et al.antibodies eIF4E (mouse, clone A-10, SC-271480, Santa Cruz Biotechnology, 1:200) and eIF4G (rabbit, #2498; Cell Signaling Technology, 1:200) in antibody diluent (Olink Bioscience) at 37 °C for 1 h. Cells were

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eIF4G Antibody

eIF4G Antibody from Cell Signaling Technology

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Cell Signaling Technology

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eIF4G Antibody from Cell Signaling Technology

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