IRS-1 (59G8) Rabbit mAb 2390S from Cell Signaling Technology

Product Specs
ItemIRS-1 (59G8) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number2390S
Quantity100 µl
ApplicationsW
ReactivityH, M, R
TargetIRS-1
HostRabbit
NCBI Gene AliasesHIRS-1
ClonalityMonoclonal
NCBI Full Gene Nameinsulin receptor substrate 1
ModificationsIRS-1 (Ser307) phosphate
Research AreaMetabolism
IsotypeIgG
Clone59G8
Molecular Weight180

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Ubiquitination of glucose and lipid metabolic proteins is altered in diabetic rat liversLife SciencesJanuary 15, 2026Ehab M. Abo-Ali, Divya K. Shetty, Rhema Khairnar, Sunil Kumar, Vikas V. Dukhandefrom Cell Signaling were used at a 1:1000 dilution: IRβ (3025S), phospho-Tyr1345 IRβ (3026S), IRS-1 (2390S), phospho-Tyr895 IRS-1 (3070S), Akt (9272S), phospho-Ser473 Akt (4056S), ubiquitin (3936S), K48-linkage-specific

(2) GLP-1 receptor agonist protects glucose-stimulated insulin secretion in pancreatic β-cells against lipotoxicity via PPARδ/UCP2 pathwayCell Mol Life SciOctober 30, 2025Zhigu Liu, Yalan Chen, Yanna Su, Yueyue Peng, Fen Xu, Bin Yao, Hua Liang, Beisi Lin, Wen XuUCP2 (1:1000, 89326 S, CST), PDX1 (1:1000, ab219207, Abcam), MAFA (1:1000, 7937 S, CST), IRS1 (1:1000, 2390 S, CST), GCK (1:1000, 19666-1-AP, Proteintech), β-ACTIN (1:1000, PM053, MBL) and β-TUBULIN (1:1000,

(3) Comparison of the characteristics of non-alcoholic fatty liver disease in C57BL/6J-Lepr^em1hwl/Korl and C57BLKS/J-Lepr^db/J miceExperimental AnimalsOctober 8, 2025Seungwoo Lee, Jae-Hong Min, Myoung Jun Kim, Somi Yun, Min Kyoung Seo, Jong Kwon Lee(#97585), fatty acid synthase (Fas, #3180), adhesion G protein-coupled receptor E1 (F4/80, #70076), IRS1 (#2390), and p-Stat3 (Tyr705) (#9145) were obtained from Cell Signaling Technology (Beverly, MA, USA). Anti-β-actin

(4) Differences in inflammatory markers, mitochondrial function, and synaptic proteins in male and female Alzheimer's disease post mortem brainsAlzheimers DementOctober 1, 2025Alex J. T. Yang, Ahmad Mohammad, Robert W. E. Crozier, Lucas Maddalena, Evangelia Tsiani, Adam, J. MacNeil, Gaynor E. Spencer, Aleksandar Necakov, Paula Duarte-Guterman, Jeffery Stuart, et al.substrate 1 (IRS‐1 S636; Cell Signaling Technology #2388), total IRS‐1 (Cell Signaling Technology #2390), mTOR S2448 (Cell Signaling Technology #2971), total mTOR (Cell Signaling Technology #2972), Akt T308

(5) Dynamic regulation of the COPII interactome and collagen trafficking by site-specific glycosylation of Sec24DbioRxivJune 17, 2025Tetsuya Hirata, Dharmendra Choudhary, Brittany J. Bisnett, Erik J. Soderblom, Ela W. Knapik, Michael Boyceanti-Calnexin (C5C9, #2679), Rabbit monoclonal anti-CD44 (E7K2Y, #37259), Rabbit monoclonal anti-IRS-1 (59G8, #2390), and Rabbit anti-HA (C29F4, #3724) from Cell Signaling Technology; Mouse anti-c-Myc (9E10, #626802),

(6) An estrogen receptor α-derived peptide improves glucose homeostasis during obesityNature CommunicationsApril 22, 2024Wanbao Yang, Wen Jiang, Wang Liao, Hui Yan, Weiqi Ai, Quan Pan, Wesley A. Brashear, Yong Xu, Ling He, Shaodong Guothen incubated with primary antibodies including anti-IRS1 antibody (Cell Signaling Technology, Cat# 2390, Dilution: 1:1000), anti-IRS2 antibody (Cell Signaling Technology, Cat# 4502, Dilution: 1:1000), anti-pAKT-S473

(7) LncRNA H19 inhibition impairs endoplasmic reticulum-mitochondria contact in hepatic cells and augments gluconeogenesis by increasing VDAC1 levelsRedox biologyFebruary 1, 2024Nandwani A, Rathore S, Datta M.ERK1/2 (Cat no. 4695), p-ERK1/2 (Cat no. 4377), p38 (Cat no. 9228), p-P38 (Cat no. 9216), IRS1 (Cat no. 2390), p-AKT (Ser473, Cat no. 4060) and AKT (Cat no. 4685): Cell Signaling Technology, MA, USA; JNK (Cat

(8) The Anticancer Effects of Marine Carotenoid Fucoxanthin through Phosphatidylinositol 3-Kinase (PI3K)-AKT Signaling on Triple-Negative Breast Cancer CellsMoleculesDecember 21, 2023Shade’ A. Ahmed, Patricia Mendonca, Samia S. Messeha, Ebenezer T. Oriaku, Karam F. A. Solimanspecific to each protein from Cell Signaling Technology® were as follows: IRS-1 (59G8) Rabbit mAb #2390S, EIF4B Antibody #3592S, RhoA (67B9) Rabbit mAb #2117S, Elk-1 Antibody #9182S, and Beta-Actin (13E5)

(9) Influence of metabolic stress and metformin on synaptic protein profile in SH‐SY5Y‐derived neuronsPhysiological ReportsNovember 27, 2023Alex J. T. Yang, Ahmad Mohammad, Michael S. Finch, Evangelia Tsiani, Gaynor Spencer, Aleksandar Necakov, Rebecca E. K. MacPhersonet al., 2022)), IRS1 S636 (Cell signaling #2388 (Uddin et al., 2019)), total IRS1 (Cell signaling #2390 (Tang et al., 2019)), mTOR S2448 (Cell signaling #2971 (Luo et al., 2022)), total mTOR (Cell signaling

(10) The Effect of Lower Limb Combined Neuromuscular Electrical Stimulation on Skeletal Muscle Signaling for Glucose Utilization, Myofiber Distribution, and Metabolic Function after Spinal Cord InjuryInternational journal of environmental research and public healthOctober 21, 2023Alharbi A, Li J, Womack E, Farrow M, Yarar-Fisher C.,Cell Signaling,1:1000,Rabbit Phosphor (Ser641)-GS,Primary antibody,3891S,Cell Signaling,1:1000,Rabbit IRS-1,Primary antibody,2390S,Cell Signaling,1:1000,Rabbit Phospho (Tyr895)-IRS-1,Primary antibody,3070S,Cell Signaling,1:1000,Rabbit List

(11) Euscaphis japonica Kanitz Fruit Exerts Antiobesity Effects by Inhibiting the Early Stage of Adipogenic DifferentiationNutrientsJuly 8, 2023Eunbi Lee, Juhye Park, Ju-Ock Namantibody,Primary antibody,Primary antibody PPARγ,SCBT,sc-7273,M,1:500 C/EBPα,CST,2295S,R,1:1000 IRS1,CST,2390S,R,1:1000 p-IRS1,Invitrogen,2103503,R,1:1000 Akt,CST,4691S,R,1:1000 p-Akt,CST,4060S,R,1:1000 β-actin,SCBT,sc-47778,M,1:500 β-tubulin,Abcam,ab179513,R,1:1000 Secondary

(12) Genetic deletion of skeletal muscle iPLA(2)γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolismiScienceJune 16, 2023Moon SH, Dilthey BG, Guan S, Sims HF, Pittman SK, Keith AL, Jenkins CM, Weihl CC, Gross RW.,Cell Signaling Technology,Cat# 11998; RRID:AB_2750900 IRS-1 (59G8) Rabbit mAb antibody,Cell Signaling Technology,Cat# 2390; RRID:AB_10692516 GSK-3α/β (D75D3) Rabbit mAb antibody,Cell Signaling Technology,Cat# 5676; RRID:AB_10547140 Phospho-GSK-3α/β (Ser21/9) antibody

(13) Xiaoyaosan ameliorates depressive-like behavior and susceptibility to glucose intolerance in rat: involvement of LepR-STAT3/PI3K pathway in hypothalamic arcuate nucleusBMC complementary medicine and therapiesApril 12, 2023Qiu W, Wu Q, Zhang K, Da X, Tang K, Yuan N, Deng L, Wu M, Zhang Y, Quan J, et al.Cat.#4904; p-IRS-1 (Ser307), Cell Signaling Technology, Cat. #2381; IRS-1, Cell Signaling Technology, Cat. #2390; p-PI3K p85(Tyr458)/p55(Tyr199), Cell Signaling Technology, Cat. #4228; PI3K, Cell Signaling Technology,

(14) Short-Term Growth Hormone Administration Mediates Hepatic Fatty Acid Uptake and De Novo Lipogenesis Gene Expression in Obese RatsBiomedicinesMarch 29, 2023Sutharinee Likitnukul, Sumpun Thammacharoen, Orada Sriwatananukulkit, Chanathip Duangtha, Ruedee Hemstapat, Chotchanit Sunrat, Supachoke Mangmool, Darawan Pinthongalpha (PI3K p110 α #4249), JAK2 #3230, STAT5 #94205, AKT #9272, insulin receptor substrate-1 (IRS-1 #2390), fatty acid synthase (FAS #3180) (Cell Signaling Technology®, Danvers, MA, USA). After washing, the

(15) Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancerOncogeneMarch 1, 2023Wang K, Yu Y, Wang W, Jiang Y, Li Y, Jiang X, Qiao Y, Chen L, Zhao X, Liu J, et al.the membranes were incubated with the following primary antibodies: IRS1(Cell Signaling Technology; 2390 S; 1:1000), phospho-Akt t308 (Cell Signaling Technology, 2965 S; 1:1000), phospho-Akt s473 (Cell Signaling Technology

(16) Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic musclesThe Journal of PhysiologyMarch 1, 2023Abdulrahman Jama, Abdullah A. Alshudukhi, Steve Burke, Lixin Dong, John Karanja Kamau, Andrew Alvin Voss, Hongmei RenAb64159, 1:1000), Mef2c (Cell Signaling Technology, 5030, 1:1000), IRS1 (Cell Signaling Technology, 2390, 1:1000), AKT (Cell Signaling Technology, 4691; 1:1000), p-AKT S473 (Cell Signaling Technology, 9271,

(17) Oncostatin M promotes lipolysis in white adipocytesAdipocyteDecember 31, 2022Pim P. van Krieken, Julian Roos, Pamela Fischer-Posovszky, Stephan Wueest, Daniel KonradTyr705, #9145; STAT3, #9132; ATGL, #2138; pHSL Ser563, #4139; HSL, #4107; Perilipin-1, #9349; IRS1, #2390 (1:1.000; all from Cell Signalling); p-Perilipin Ser522, #4856 (1:1.000; Vala Sciences); pIRS1 Ser307,

(18) Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese miceRedox BiologyNovember 1, 2022Ya Zhang, Yang Cheng, Jian Liu, Jihui Zuo, Liping Yan, Ronald W. Thring, Xueqing Ba, Dake Qi, Mingjiang Wu, Yitian Gao, et al.Bio-Technology Co., Ltd. (Beijing, China). Antibodies against Akt (#4691), phospho-Akt (Ser473, #4060), IRS-1 (#2390), phospho-IRS-1 (Ser307, #2381), KEAP1 (#8047), GAPDH (#5174), lamin B1 (#13435) and β-tubulin (#2128)

(19) H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetesMolecular medicine (Cambridge, Mass.)July 16, 2022Kumar A, Datta M.Darmstadt, Germany) and 20–30 µg protein was subjected to western blotting to evaluate the levels of IRS1 (2390S; Cell Signaling Technology, USA), p-IRS1-Tyr612 (ab66153; Abcam, USA), Akt (4685S; Cell Signaling Technology,

(20) 17β-Estradiol Treatment Improves Acetylcholine-Induced Relaxation of Mesenteric Arteries in Ovariectomized UC Davis Type 2 Diabetes Mellitus Rats in Prediabetic StateFrontiers in PhysiologyJune 17, 2022Md Rahatullah Razan, Farjana Akther, Rifat A. Islam, James L. Graham, Kimber L. Stanhope, Peter J. Havel, Roshanak Rahimianphospho-AMP-activated protein kinase-α (pAMPK-α, Thr-172) (#2535), insulin receptor substrate 1 (IRS1) (#2390) were obtained from Cell Signaling Technology (Danvers, MA). Antibodies against NADPH oxidase-1 (NOX-1)

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IRS-1 (59G8) Rabbit mAb

IRS-1 (59G8) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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IRS-1 (59G8) Rabbit mAb from Cell Signaling Technology

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