Pyk2 Antibody 3292S from Cell Signaling Technology

Product Specs
ItemPyk2 Antibody
CompanyCell Signaling Technology
Price $306.00 Inquire
Catalog Number3292S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M
TargetPyk2
HostRabbit
NCBI Gene AliasesCADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK
NCBI Full Gene Nameprotein tyrosine kinase 2 beta
ClonalityPolyclonal
Research AreaMAP Kinase Signaling
Molecular Weight116

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) A novel MMP13 frameshift variant causes short stature via enhanced MMP13–HSPA5 interaction and activated endoplasmic reticulum stressClinical and Translational MedicineMarch 24, 2026Huifei Lu, Xin Feng, Suping Dai, Yilin Zhu, Ke Yuan, Yonghua Chen, Jianfang Zhu, Yanlan Fang, Qingfeng Yan, Chunlin Wanganti‐SSEA4(4755, 1:50 for IF), anti‐TRA‐1‐60 (4746, 1:50 for IF), anti‐GRP94 (2104, 1:1000 for WB), anti‐PERK (3292, 1:1000 for WB), anti‐IRE1α (3294, 1:1000 for WB) and anti‐ATF6 (65880, 1:1000 for WB) from CST; anti‐MMP13

(2) Window of opportunity study measuring defactinib and avutometinib delivery in glioblastomasCancer Chemother PharmacolMarch 6, 2026Miguel Mayol Del Valle, Emely Morales Colon, Kavitha Kettimuthu, Kristal Maner-Smith, Jeffrey J. Olson, Lilia Y. Kucheryavykhp-Erk1/2[Thr202/Tyr204], MEK1/2, p-MEK1/2[Ser217/221] (Cell Signaling Technology, Danvers, MA, USA, cat. #3292, #3284, #3285, #4696, #4370, #4694, #9154, respectively). GAPDH (Cell Signaling Technology, Danvers,

(3) LYP regulates SLP76 and other adaptor proteins in T cellsBiological ResearchSeptember 28, 2024Virginia Ruiz-Martín, Tamara Marcos, José María de Pereda, Mariano Sánchez-Crespo, Miguel Angel de la Fuente, Yolanda Bayón, Andrés AlonsoCell Signalling #3584, LAT antibody Rabbit Mab was from Cell Signalling #45533, and Pyk2 from Cell Signalling #3292. Anti-ERK2 Ig (rabbit polyclonal, C14) from Santa Cruz Biotechnology (CA, USA), and P-ERK1/2 (Thr202/Tyr204)

(4) Enhanced phagocytosis associated with multinucleated microglia via Pyk2 inhibition in an acute β-amyloid infusion modelJournal of NeuroinflammationAugust 6, 2024Ji-Won Lee, Kaito Mizuno, Haruhisa Watanabe, In-Hee Lee, Takuya Tsumita, Kyoko Hida, Yasutaka Yawaka, Yoshimasa Kitagawa, Akira Hasebe, Tadahiro Iimura, et al.(Anti-rabbit, Cell Signaling Technology #3291, 1:1000), Pyk2 (Anti-rabbit, Cell Signaling Technology #3292, 1:1000), pFAK (Anti-rabbit, Cell Signaling Technology #3283, 1:1000), FAK (Anti-Rabbit, Cell Signaling Technology

(5) Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axisLife science allianceJuly 1, 2024Toshima T, Yagi M, Do Y, Hirai H, Kunisaki Y, Kang D, Uchiumi T.Cell Signaling), Gsk3β [pTyr216] (NB100-81946; Novus Biologicals), Gsk3β [pSer9] (9323; Cell Signaling), Pyk2 (3292S; Cell Signaling), Pyk2 [pTyr402] (3291S; Cell Signaling), COX1 (459600; Novex by life technologies),

(6) Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein responseRedox biologyFebruary 1, 2024Xue M, Irshad Z, Rabbani N, Thornalley PJ.rabbit monoclonal anti-human IRE1α, clone 14C10 (Cat no 3294), anti-human PERK, clone C33E10 (Cat no 3292), anti-human phospho-PERK [Thr980] (Cat no 3179) and anti-human TXNIP, clone D5F3E (Cat no 14715), and

(7) Cocaine and habit training cause dendritic spine rearrangement in the prelimbic cortexiScienceApril 21, 2023Sequeira MK, Swanson AM, Kietzman HW, Gourley SL.sequence,Rabbit,Cell Signaling Technology,3291S,1:1000 anti-Pyk2,N-terminus domain,Rabbit,Cell Signaling Technology,3292S,1:1000 anti-p-ROCK2,Proprietary sequence,Rabbit,GeneTex,GTX122651,1:1000 anti-ROCK2,aa 1-100,Rabbit,Abcam,ab71598,1:500 anti-p-LIMK,Proprietary

(8) A novel drug-like water-soluble small molecule Focal Adhesion Kinase (FAK) activator promotes intestinal mucosal healingCurrent Research in Pharmacology and Drug DiscoveryJanuary 12, 2023Qinggang Wang, Ricardo Gallardo-Macias, Emilie E. Vomhof-DeKrey, Rashmi Gupta, Svetlana A. Golovko, Mikhail Y. Golovko, Sema Oncel, Vadim J. Gurvich, Marc D. Basson(Anti-FAK, clone 4.47, 05–537, 1:1000 dilution) were from EMD Millipore, (Temecula, CA), and Pyk2 (3292 s, 1:1000 dilution) was from Cell Signaling Technology (Danvers, MA). Secondary antibodies anti-rabbit

(9) Cell Competition Shapes Metastatic Latency and RelapseCancer discoveryJanuary 9, 2023Kim K, Huang H, Parida PK, He L, Marquez-Palencia M, Reese TC, Kapur P, Brugarolas J, Brekken RA, Malladi S.p-DDR1 Tyr513 (Cell Signaling Technology Cat# 14513, 1:1000), PYK2 (Cell Signaling Technology Cat# 3292, RRID:AB_2174097, 1:1000), p-PYK2 (Cell Signaling Technology Cat# 3291, RRID:AB_2300530, 1:1000), AKT

(10) Expression of non-phosphorylatable S5A-L-plastin exerts phenotypes distinct from L-plastin deficiency during podosome formation and phagocytosisFrontiers in cell and developmental biologyJanuary 1, 2023Lin X, Krishnamoorthy P, Walker EC, Joshi H, Morley SC.cat#: ab176759). Primary antibodies used for Western blot include: anti-Pyk2 (Cell Signaling; cat#: 3292S), anti-vinculin (Santa Cruz Biotechnology, Inc.; cat#: sc-25336), and anti-beta actin (Cell Signaling;

(11) Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pHCardiovascular researchNovember 10, 2022Wilson AD, Richards MA, Curtis MK, Gunadasa-Rohling M, Monterisi S, Loonat AA, Miller JJ, Ball V, Lewis A, Tyler DJ, et al.(TBS-T). Primary antibodies were incubated overnight at 4°C. Antibodies used were: total-Pyk2 (CST 3292S, 1:1000); phospho-Pyk2 Y402 (Abcam 4800, 1:1000); phospho-Pyk2 Y579/580 (Invitrogen 44-636G, 1:1000);

(12) SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosisEBioMedicineNovember 1, 2022Wang D, Lin Y, Xu F, Zhang H, Zhu X, Liu Z, Hu Y, Dong G, Sun B, Yu Y, et al.LC3-I/II(Cell Signaling Technology Cat# 12741, RRID:AB_2617131); PTK2B(Cell Signaling Technology Cat# 3292, RRID:AB_2174097); p-PTK2B(Cell Signaling Technology Cat# 3291, RRID:AB_2300530); UB (Cell Signaling Technology

(13) PYK2 mediates the BRAF inhibitor (vermurafenib)-induced invadopodia formation and metastasis in melanomasCancer Biology & MedicineAugust 15, 2022Junling Shen, Jilong Yang, Lei Sang, Rui Sun, Weiyu Bai, Chao Wang, Yan Sun, Jianwei Sun(PYK2 sh2). Antibodies The following antibodies were used in this study: rabbit polyclonal anti-PYK2 (3292; Cell Signaling Technology, Danvers, MA, USA), rabbit polyclonal anti-p-PYK2 (Y402) (3291; Cell Signaling Technology

(14) Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesisBloodJuly 21, 2022Wang S, Wang B, Shi Y, Möller T, Stegmeyer RI, Strilic B, Li T, Yuan Z, Wang C, Wettschureck N, et al.Proteintech (15939-1-AP). Anti-GAPDH (catalog no. 5174), anti-protein tyrosine kinase 2 (PYK2) (catalog no. 3292), anti–p-PYK2 (Tyr402; 3291), antisarcoma (SRC) (2109), anti–p-SRC (Tyr416; 6943), anti-MLC (3672),

(15) Expanding anti-CD38 immunotherapy for lymphoid malignanciesJournal of experimental & clinical cancer research : CRJune 28, 2022Wang X, Yu X, Li W, Neeli P, Liu M, Li L, Zhang M, Fang X, Young KH, Li Y.Sigma-Aldrich. Anti-CD38 (cat. # ab108403) antibody was obtained from Abcam (Cambridge, UK). Anti-PYK2 (cat. #3292S) and anti-p-PYK2 (cat. #3291S) were obtained from Cell Signaling Technology (Danvers, MA). Xenograft

(16) Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathyMolecular neurodegenerationMay 3, 2022Brody AH, Nies SH, Guan F, Smith LM, Mukherjee B, Salazar SA, Lee S, Lam TKT, Strittmatter SM.anti-GSK3β Y216/pGSK3α Y279 (Abcam #ab52188, 1:1000, RRID:AB_880261), anti-Pyk2 (Cell Signaling Technology #3292, 1:1000, RRID:AB_2174097) and anti-β-Actin (Cell Signaling Technology #8457, 1:1000, RRID:AB_10950489).

(17) A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathwaysNature communicationsApril 19, 2022de Rooij MFM, Thus YJ, Swier N, Beijersbergen RL, Pals ST, Spaargaren M.rabbit anti-PKM2 (Polyclonal, #3198, Cell Signaling Technologies), rabbit anti-PTK2B (Polyclonal, #3292, Cell Signaling Technologies), mouse anti-BTK (Clone 53/BTK, #611117, BD Transduction Laboratories),

(18) Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca²⁺ release in cancer cellsCell death & diseaseMarch 16, 2022Tangeda V, Lo YK, Babuharisankar AP, Chou HY, Kuo CL, Kao YH, Lee AY, Chang JY.previously [33]. The antibodies used in this study were purchased as indicated: antibodies to PYK2(#3292), p-PYK2 (Tyr 402) (#3291), Src, p-Src (Tyr 416) (#2101 s), STAT3 (#GTX104616), p-STAT3 (Tyr 705) (#9131)were

(19) Pyk2 Stabilizes Striatal Medium Spiny Neuron Structure and Striatal-Dependent ActionCellsDecember 7, 2021Shannon L. Gourley, Kolluru D. Srikanth, Ellen P. Woon, Hava Gil-HennWestern Blot Analysis of Cell Culture and Brain Samples Anti-Pyk2 was obtained from Cell Signaling Technology (3292); anti-FAK (clone 77; 610088) was obtained from BD Biosciences. Additional anti-FLAG (clone M2; F3165)

(20) Microglial Cytokines Induce Invasiveness and Proliferation of Human Glioblastoma through Pyk2 and FAK ActivationCancersDecember 7, 2021Nuñez RE, Del Valle MM, Ortiz K, Almodovar L, Kucheryavykh L.Pyk2 (1:1000), p-FAK (Y925) (1:1000), FAK (1:1000) (Cell Signaling Technology, Danvers, MA, USA, cat. #3292, #3284, #3285, respectively). Total protein staining with REVERT Total Protein Stain (LI-COR Biotechnology,

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Pyk2 Antibody

Pyk2 Antibody from Cell Signaling Technology

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Cell Signaling Technology

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Pyk2 Antibody from Cell Signaling Technology

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