Fig 1: (A) Functional annotation clustering (using DAVID 6.7) of proteins excluded from EVs. 1: Nucleolus; 2: Nucleoplasm; 3: RNA splicing; 4: Nucleotide binding; 5: Nucleolus; 6: Histone modification; 7: DNA binding; 8: RNA binding; 9: Apoptosis; 10: FHA regulatory proteins; 11: Isopeptide bond; 12: N-acetyltransferase activity; 13: GTPase regulator activity; 14: ATP binding; 15: RNA transport; 16: DNA replication; 17: Mitochondria; 18: Ubiquitin protein activity; 19: Transcription factors; 20: Macromolecular complex assembly; 21: Lipid synthesis; 22: Vesicle-mediated transport; 23: Transcription cofactor activity; 24: Helicase activity; 25: Regulation of cell death; 26: Cell division; 27: Regulation of transferase activity; 28: DNA repair; 29: Respiratory development; 30: Eye development; 31: Mitochondrial membrane; 32: Protein transport; 33: Transcription regulator activity; 34: Signaling proteins; 35: Transcription repressor activity; 36: Zinc fingers; 37: Organelle membrane; 38: Protein kinase cascade; 39: Vasculature development; 40: Immune system development; 41: MAPkinase signaling pathway; 42: Endoplasmic reticulum; 43: WD40 repeat region; 44: Zinc finger; 45: GTP binding; 46: Magnesium ion binding; 47: Cytoskeleton; 48: Enzyme receptor signaling; 49: Calcium ion binding; 50: Spermatogenesis; 51: Response to hormone stimulus; 52: Cell migration; 53: Cytoplasmic vesicle; 54: Protein dimerization activity; 55: Peptidase activity; 56: Cell fraction. (B) Expression of the candidate proteins complement component (C2), vascular endothelial growth factor (VEGF), von Willebrand factor (vWF), RNA polymerase-associated protein RTF1 homolog (RTF1), and FOS-Like Antigen 1 (FOSL1) was in accordance to the proteomics findings.