Fig 1: Normalization of neuronal hyperexcitability through pharmacological and ketogenic diet approaches(A, C, J, and L) Left: scheme of experiment to monitor SC-to-CA1 synaptic and somatic signaling (S1: stimulation; Rec: recording). Right: cartoon of adenosine signaling.(B) FV-fEPSP data points (left) and individual paired slope data points (right) before (a) and after (b) dosage of the A1R blocker; DMSO: n = 9/4, 5-ITU: n = 7/6.(D) PS-FV data points (left) and individual paired slope data points (right) before (a) and after (b) dosage of the A1R blocker; DMSO: n = 7/4, 5-ITU: n = 7/6.(E) Top: representative western blots. Bottom: mean normalized expression and single data points (CD73: DMSO: n = 5, 5-ITU:n = 5; CD39: DMSO: n = 5, 5-ITU:n = 6).(F) Regular diet (RD, green) and ketogenic diet (KD, blue) regime and KD composition. At P28, KD group received ad libitum KD for a month (P56). Time trajectories of (G) weight, (H) ketone bodies/weight, and (I) glucose/weight for RD and KD groups.(K) FV-fEPSP data points (left) and individual paired slope data points (right) before (a) and after (b) dosage of the A1R blocker; RD: n = 12/12, KD: n = 9/9.(M) PS-FV data points (left) and individual paired slope data points (right) before (a) and after (b) dosage of the A1R blocker; RD: n = 6/6, KD: n = 7/7.(N) Top: representative western blots. Bottom: mean normalized expression and single data points (CD73: RD: n = 11, KD: n = 11; CD39: RD: n = 12, KD: n = 10). p value; d: Cohen’s effect size. Mean ± S.D. n = n. slices/n. mice. Statistic: generalized linear mixed effect models. Dark green: APPKI+DMSO, orange: APPKI+5-ITU, light green: APPKI-RD, blue: APPKI-KD.